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Imaging Features of Granulomatosis with Polyangiitis (Wegener’s)

  • Stéphane Silvera
  • Estelle Palangié
  • Loîc Guillevin
  • Lotfi Hendaoui
  • Paul Legmann
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Granulomatosis with polyangiitis or Wegener’s granulomatosis is a small-vessel vasculitis characterized by necrotizing granulomatous inflammation with involvement of: (1) Upper airways (sinusitis, otitis, ulcerations, bone deformities, subglotic or bronchial stenosis), (2) Lower respiratory tract (cough, chest pain, dyspnea, and hemoptysis), (3) Glomerulonephritis (hematuria, red blood cell casts, proteinuria, and azotemia). When Granulomatosis with polyangiitis (Wegener’s) is suspected, the search to locate involvement of the upper respiratory tract, lungs and airways, CNS, or kidneys should include: (a) A clinical ORL exam and a sinonasal CT or MRI, (b) A high resolution chest CT, (c) An electrocardiogram (ECG), (d) Research of proteinuria and urinary sediment, (e) An ophthalmological exam, (f) Titers of c-ANCA and PR3 (antiprotease 3).

Keywords

Idiopathic Pulmonary Fibrosis Central Nervous System Involvement Granulomatous Inflammation Bronchiolitis Obliterans Diffuse Alveolar Hemorrhage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg  2011

Authors and Affiliations

  • Stéphane Silvera
    • 1
  • Estelle Palangié
    • 1
  • Loîc Guillevin
    • 2
  • Lotfi Hendaoui
    • 3
  • Paul Legmann
    • 1
  1. 1.Department of Radiology and Medical Imaging, Cochin HospitalRené Descartes University, Paris VParis Cedex 14France
  2. 2.Department of Internal Medicine, Cochin HospitalRené Descartes University, Paris VParis Cedex 14France
  3. 3.Department of Medical Imaging and Imaging Guided Interventions, Medical School of TunisMongi Slim University HospitalSidi DaoudTunisia

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