Intraoperative Radiotherapy in Lung Cancer: Methodology (Electrons or Brachytherapy), Clinical Experiences and Long-Term Institutional Results

  • Felipe A. Calvo
  • Javier Aristu
  • Sergey Usychkin
  • Leire Arbea
  • Rosa Cañón
  • Ignacio Azinovic
  • Rafael Martinez-Monge
Part of the Medical Radiology book series (MEDRAD)


Intraoperative radiotherapy is a feasible technical modality to improve precision and dose-escalation in high-local risk lung cancer patients. Methodology is described regarding the use of high-energy electron beams or brachytherapy. Results of normal tissue tolerance in experimental animal models and in clinical experiences are analyzed in detail. Characteristics of clinical experiences using IORT electrons or brachytherapy are reported and clinical outcome results are discussed. Ten IORT brachytherapy and six electron-based publications are identified proving the adaptability of IORT to the clinical-therapeutic scenario of lung cancer, its feasibility and the promotion of high local control rates in the context of dose-escalation trials.


NSCLC Patient Lung Cancer Surgery Microscopic Residual Disease Bronchial Stump Superior Sulcus Tumor 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Felipe A. Calvo
    • 1
  • Javier Aristu
    • 2
  • Sergey Usychkin
    • 3
  • Leire Arbea
    • 2
  • Rosa Cañón
    • 4
  • Ignacio Azinovic
    • 4
  • Rafael Martinez-Monge
    • 5
  1. 1.Department of OncologyUniversity Hospital Gregorio Marañón, University ComplutenseMadridSpain
  2. 2.Department of OncologyUniversity Clinic, University of NavarrePamplonaSpain
  3. 3.Department of RadiotherapyInstituto Madrileño de OncologíaMadridSpain
  4. 4.Department of Radiation OncologyHospital San JaimeTorreviejaSpain
  5. 5.Department of Radiation OncologyClinica Universitaria de NavarraPamplonaSpain

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