Skip to main content
SpringerLink
Log in

Advances in Radiation Oncology of Lung Cancer

  • Chapter
  • First Online:
Advances in Radiation Oncology in Lung Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 1739 Accesses

Abstract

A variety of advanced radiation technologies are currently available that have changed the way we practice Radiation Oncology. In this chapter, the authors will review one such technology, Helical tomotherapy. Basic operations and planning, applications in stereotactic body radiotherapy, and locally advanced lung cancer, as well as developing and future applications in hippocampal sparing whole brain radiation, adaptive radiation, and theragnostic radiation delivery will also be discussed.

Disclosures Dr. Khuntia serves on the advisory board of Radion Global and has received the speakers honorarium for Tomotherapy. Dr. Mehta serves as a consultant for Tomotherapy, and holds stock options in Tomotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adkison JB, Khuntia D et al (2008) Dose escalated, hypofractionated radiotherapy using helical tomotherapy for inoperable non-small cell lung cancer: preliminary results of a risk-stratified phase I dose escalation study. Technol Cancer Res Treat 7(6):441–447

    PubMed  CAS  Google Scholar 

  • Aoyama H, Tago M et al (2007) Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. Int J Radiat Oncol Biol Phys 68(5):1388–1395

    Article  PubMed  Google Scholar 

  • Belderbos JS, Heemsbergen WD et al (2006) Final results of a Phase I/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 66(1):126–134

    Article  PubMed  Google Scholar 

  • Bentzen SM, Gregoire V (2011) Molecular imaging-based dose painting: a novel paradigm for radiation therapy prescription. Semin Radiat Oncol 21(2):101–110

    Article  PubMed  Google Scholar 

  • Chang EL, Wefel JS et al (2009) Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol 10(11):1037–1044

    Article  PubMed  Google Scholar 

  • Chi A, Jang SY et al (2011) Feasibility of helical tomotherapy in stereotactic body radiation therapy for centrally located early stage nonsmall-cell lung cancer or lung metastases. Int J Radiat Oncol Biol Phys Jan 19 (Epub ahead of print).

    Google Scholar 

  • Dawson LA, Jaffray DA (2007) Advances in image-guided radiation therapy. J Clin Oncol Official J Am Soc Clin Oncol 25(8):938–946

    Article  Google Scholar 

  • DeAngelis LM, Delattre JY et al (1989) Radiation-induced dementia in patients cured of brain metastases. Neurology 39(6):789–796

    Article  PubMed  CAS  Google Scholar 

  • Gondi V, Tolakanahalli R et al (2010a) Hippocampal-sparing whole-brain radiotherapy: a “how-to” technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 78(4):1244–1252

    Article  PubMed  Google Scholar 

  • Gondi V, Tome WA et al (2010b) Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933. Radiother Oncol J Eur Soc Therap Radiol Oncol 95(3):327–331

    Article  Google Scholar 

  • Hodge W, Tome WA et al (2006) Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionation. Acta Oncol 45(7):890–896

    Article  PubMed  Google Scholar 

  • Khuntia D, Brown P et al (2006) Whole-brain radiotherapy in the management of brain metastasis. J Clin Oncol Official J Am Soc Clin Oncol 24(8):1295–1304

    Article  CAS  Google Scholar 

  • Kong FM, Ten Haken RK et al (2005) High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study. Int J Radiat Oncol Biol Phys 63(2):324–333

    Article  PubMed  Google Scholar 

  • Mackie TR, Balog J et al (1999) Tomotherapy. Semin Radiat Oncol 9(1):108–117

    Article  PubMed  CAS  Google Scholar 

  • Mackie TR, Kapatoes J et al (2003) Image guidance for precise conformal radiotherapy. Int J Radiat Oncol Biol Phys 56(1):89–105

    Article  PubMed  Google Scholar 

  • Mehta M, Scrimger R et al (2001) A new approach to dose escalation in non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 49(1):23–33

    Article  PubMed  CAS  Google Scholar 

  • Mizumatsu S, Monje ML et al (2003) Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res 63(14):4021–4027

    PubMed  CAS  Google Scholar 

  • Monje ML, Mizumatsu S et al (2002) Irradiation induces neural precursor-cell dysfunction. Nat Med 8(9):955–962

    Article  PubMed  CAS  Google Scholar 

  • Monje ML, Toda H et al (2003) Inflammatory blockade restores adult hippocampal neurogenesis. Science 302(5651):1760–1765

    Article  PubMed  CAS  Google Scholar 

  • Nagata Y, Takayama K et al (2005) Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int J Radiat Oncol Biol Phys 63(5):1427–1431

    Article  PubMed  Google Scholar 

  • Perez CA, Stanley K et al (1980) A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung. Preliminary report by the Radiation Therapy Oncology Group. Cancer 45(11):2744–2753

    Article  PubMed  CAS  Google Scholar 

  • Schubert LK, Westerly DC et al (2009) A comprehensive assessment by tumor site of patient setup using daily MVCT imaging from more than 3, 800 helical tomotherapy treatments. Int J Radiat Oncol Biol Phys 73(4):1260–1269

    Article  PubMed  Google Scholar 

  • Shah AP, Langen KM et al (2008) Patient dose from megavoltage computed tomography imaging. Int J Radiat Oncol Biol Phys 70(5):1579–1587

    Article  PubMed  Google Scholar 

  • Siker ML, Tome WA et al (2006) Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy: how reliable, consistent, and meaningful is the effect? Int J Radiat Oncol Biol Phys 66(1):135–141

    Article  PubMed  Google Scholar 

  • Song CH, Pyo H et al (2010) Treatment-related pneumonitis and acute esophagitis in non-small-cell lung cancer patients treated with chemotherapy and helical tomotherapy. Int J Radiat Oncol Biol Phys 78(3):651–658

    Article  PubMed  Google Scholar 

  • Timmerman R, McGarry R et al (2006) Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol Official J Am Soc Clin Oncol 24(30):4833–4839

    Article  Google Scholar 

  • Yoon SM, Choi EK et al (2006) Clinical results of stereotactic body frame based fractionated radiation therapy for primary or metastatic thoracic tumors. Acta Oncol 45(8):1108–1114

    Article  PubMed  Google Scholar 

  • Yuan S, Sun X et al (2007) A randomized study of involved-field irradiation versus elective nodal irradiation in combination with concurrent chemotherapy for inoperable stage III nonsmall cell lung cancer. Am J Clin Oncol 30(3):239–244

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Western Radiation Oncology, 125 South Drive, Mountain View, CA, 94040, USA

    Deepak Khuntia

  2. Northwestern University, 676 N St. Clair, Suite 1800, 60611, Chicago, IL, USA

    Minesh P. Mehta

Authors
  1. Deepak Khuntia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Minesh P. Mehta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Deepak Khuntia .

Editor information

Editors and Affiliations

  1. Institute of Lung Diseases, Institutski put 4, Sremska Kamenica, 21204, Serbia

    Branislav Jeremic

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Khuntia, D., Mehta, M.P. (2011). Advances in Radiation Oncology of Lung Cancer. In: Jeremic, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_277

Download citation

  • DOI: https://doi.org/10.1007/174_2011_277

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-19924-0

  • Online ISBN: 978-3-642-19925-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation