Radiation-Induced Lung and Heart Toxicity

  • Liyi Xie
  • Xiaoli Yu
  • Zeljko Vujaskovic
  • Mitchell S. Anscher
  • Timothy D. Shafman
  • Keith Miller
  • Robert Prosnitz
  • Lawrence Marks
Part of the Medical Radiology book series (MEDRAD)


For many patients with lung cancer, thoracic radiation therapy (TRT) is an integral part of their treatment. The effect of TRT on normal structures is an important consideration when optimizing treatment plans for patients. This chapter will review radiation therapy (RT)-induced lung and heart injury including both the clinical and biological mechanisms for these toxicities. It will also analyze the variety of predictors of RT-induced lung and heart damage as well as methods to prevent and treat these toxicities.


Chronic Obstructive Pulmonary Disease Lung Injury Acute Myocardial Infarction Intensity Modulate Radiation Therapy Cardiac Injury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by NIH Grant 2R201 CA69579-09.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Liyi Xie
    • 1
    • 2
  • Xiaoli Yu
    • 2
  • Zeljko Vujaskovic
    • 3
  • Mitchell S. Anscher
    • 4
  • Timothy D. Shafman
    • 5
  • Keith Miller
    • 6
  • Robert Prosnitz
    • 7
  • Lawrence Marks
    • 1
  1. 1.Department of Radiation OncologyUniversity of North CarolinaChapel HillUSA
  2. 2.Department of Radiation OncologyFudan University Shanghai Cancer CenterShanghaiChina
  3. 3.Radiation Oncology and Pathology, Department of Radiation OncologyDuke University Medical CenterDurhamUSA
  4. 4.Department of Radiation OncologyVirginia Commonwealth University School of MedicineRichmondUSA
  5. 5.Landmark Medical CentreWoonsocketUSA
  6. 6.21st Century OncologyFort MyersUSA
  7. 7.Department of Radiation OncologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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