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Prophylactic Cranial Irradiation in Small-Cell Lung Cancer

  • Michael C. Stauder
  • Yolanda I. Garces
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Prophylactic cranial radiation (PCI) has been used in the management of small-cell lung cancer given the propensity of disease relapse in the brain. Several studies have shown that PCI reduces the rate of brain metastases and improves survival. However, the use of PCI in the management of small-cell lung cancer has been controversial due to conflicting evidence of efficacy and toxicities. For example, the most effective radiation dose and fractionation regimen is not known. Also, conflicting reports on the neurotoxicity of PCI make it difficult to make definitive conclusions regarding the side-effects of treatment. As the survival of patients with SCLC improves, the controversies regarding the neurotoxic effect of PCI may become more defined. Certainly, well-designed prospective clinical trials addressing these issues are needed and are ongoing.

Keywords

Complete Remission Brain Metastasis Prophylactic Cranial Irradiation Global Health Status Central Nervous System Relapse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Gy

Gray

Fx

Fractions

BID

Twice-daily

LS

Limited stage

ES

Extensive stage

SCLC

Small-cell lung cancer

NSCLC

Non-small-cell lung cancer

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Radiation OncologyMayo Clinic College of MedicineRochesterUSA

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