Angiogenesis and Lung Cancer

  • Wenyin Shi
  • Dietmar W. Siemann
Part of the Medical Radiology book series (MEDRAD)


Lung cancer is one of the most frequent causes of cancer deaths worldwide. Current treatment regimens with conventional anticancer therapies offer only a limited survival benefit. There clearly exists a need for the development of new therapeutic strategies. Recent evidence suggests that angiogenesis is critical to lung cancer progression and related to poor prognosis. Consequently tumor angiogenesis, a process that features an imbalance between pro and anti-angiogenic mediators, is being targeted by novel therapies in the treatment of lung cancer. A variety of therapeutic approaches and agents have been developed to compromise the growth and/or function of tumor vasculature. In October 2006, bevacizumab was the first antiangiogenic agent approved by the US Food and Drug Administration for the treatment of advanced, nonsquamous, nonsmall cell lung cancer in combination with platinum-based chemotherapy. Other antiangiogenic agents are actively being evaluated in pre-clinical and clinical settings.


Vascular Endothelial Growth Factor NSCLC Patient Vascular Endothelial Growth Factor Expression Advanced NSCLC Vascular Endothelial Growth Factor Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Radiation OncologyThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of Radiation OncologyShands Cancer Center, University of FloridaGainesvilleUSA

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