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Proton Therapy for Lung Cancer: State of the Science

  • David A. Bush
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Proton radiation for cancer offers to the physician the ability to conform the high-dose region to the tumor while reducing the dose of radiation to adjacent normal tissues. In lung cancer this results in the ability to deliver higher doses to the targeted volume while yet permitting greater sparing of uninvolved and critical normal tissues: lung, heart, esophagus, and spinal cord. Studies comparing the distribution of radiation dose show that proton radiation is superior to photon radiation for lung cancer, even when factors such as respiratory motion are considered. Clinical experience confirms the feasibility of proton radiation for early-stage non-small-cell lung cancers; clinical trials are being performed in locally advanced tumors. Evidence accumulated thus far indicates that proton radiation should be further explored.

Keywords

Dose Escalation Proton Beam Bragg Peak Stereotactic Body Radiation Therapy Gross Tumor Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BID

Twice-daily treatment

CGE

(sometimes expressed as GyE) Cobalt gray equivalent, a means of expressing the proton dose in relation to Gray units (cf below) while allowing for the slightly higher radiobiologic effect of protons (i.e., 1.1 in relation to cobalt)

CTV

Clinical target volume

GTV

Gross tumor volume

Gy

Gray, standard radiation dose. A common daily fraction of photon-beam radiation is 2 Gy (or 200 centigray (cGy)); a 30-fraction course of radiation at that dose rate equates to a total dose of 60 Gy

IMPT

Intensity-modulated proton therapy

IMRT

Intensity-modulated radiation therapy

NSCLC

Non-small-cell lung cancer

PTV

Planned target volume

SBRT

Stereotactic body radiation therapy

Notes

Acknowledgments

I would like to thank William Preston EdD for manuscript editing and preparation.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Radiation MedicineLoma Linda University Medical CenterLoma LindaUSA

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