Radiation Therapy for Recurrent Disease

  • Branislav Jeremić
  • Jai Prakash Agarwal
  • Sherif Abdel-Wahab
Part of the Medical Radiology book series (MEDRAD)


 Recurrence is still a dominating and bitter event after the treatment of lung cancer regardless of histology, stage, or initial treatment. All recurrences can be broadly divided into the local (e.g., lung parenchyma, bronchial stump, or chest wall), regional (e.g., mediastinal lymph nodes), and distant (e.g., brain, liver, or bones). Recurrent disease almost always present as fatal event and only anecdotal reports indicated potential for a treatment to lead to cure. Beside surgery and chemotherapy, radiation therapy has been used in this setting and was shown that it was safe and effective way of retreating recurrent non-small-cell lung cancer after initial radiation therapy. It achieved symptom control in substantial proportion of cases (overall, approximately 80%). In many studies asymptomatic patients were also included, indicating therefore, intention of more ‘‘radical’’ approach of investigators. This had led to longer survivals, especially when high-doses were successfully delivered, leading to the median survival time of 15 months and 2-year survival of 51%, not different from those achieved with contemporary radiochemotherapy studies in treatment-naive locally advanced non-small-cell lung cancer. These results were obtained at the expense of low toxicity.


Lung Cancer Median Survival Time Intensity Modulate Radiation Therapy Total Cumulative Dose Karnofsky Performance Status Score 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Branislav Jeremić
    • 1
    • 2
  • Jai Prakash Agarwal
    • 3
  • Sherif Abdel-Wahab
    • 4
  1. 1.Institute of Lung DiseasesSremska KamenicaSerbia
  2. 2.Institute of Pulmonary DiseasesSremska KamenicaSerbia
  3. 3.Department of Radiation OncolgoyTata Memorial CenterMumbaiIndia
  4. 4.Department of OncologyAin Shams UniversityCairoEgypt

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