Prophylactic Cranial Irradiation

  • Jason Francis Lester
Part of the Medical Radiology book series (MEDRAD)


The incidence of brain metastases following locoregional treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is high. Brain metastases impair quality of life and are associated with a poor prognosis. The rationale behind prophylactic cranial irradiation (PCI) is to control or eradicate undetectable micrometastases before they become clinically significant without inducing severe adverse effects. Given the profound detrimental effect on survival, treatment that reduces the incidence of brain metastases in patients with LA-NSCLC might reasonably be expected to prolong life and improve quality of life. This chapter reviews the role of PCI in LA-NSCLC with specific reference to the five randomized controlled trials carried out in this field.


Brain Metastasis Small Cell Lung Cancer Large Cell Carcinoma Prophylactic Cranial Irradiation Locoregional Treatment 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Velindre Cancer CentreCardiffUK

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