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Prophylactic Cranial Irradiation

  • Jason Francis Lester
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

The incidence of brain metastases following locoregional treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is high. Brain metastases impair quality of life and are associated with a poor prognosis. The rationale behind prophylactic cranial irradiation (PCI) is to control or eradicate undetectable micrometastases before they become clinically significant without inducing severe adverse effects. Given the profound detrimental effect on survival, treatment that reduces the incidence of brain metastases in patients with LA-NSCLC might reasonably be expected to prolong life and improve quality of life. This chapter reviews the role of PCI in LA-NSCLC with specific reference to the five randomized controlled trials carried out in this field.

Keywords

Brain Metastasis Small Cell Lung Cancer Large Cell Carcinoma Prophylactic Cranial Irradiation Locoregional Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Velindre Cancer CentreCardiffUK

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