Bladder Cancer

  • Peter Han
  • Marvin Rotman
  • Alan R. Schulsinger
  • Bradley R. Pieters
  • Caro C. E. Koning
  • Floris J. Pos
  • Maarten C. C. M. Hulshof
  • Philip Poortmans
Part of the Medical Radiology book series (MEDRAD)


The management of invasive bladder cancer requires a multidisciplinary approach to optimize the treatment of the disease while maintaining the best quality of life. In early-stage disease, combined surgery and radiation offers good results with sparing of the functional bladder in selected patients. For patients with locally advanced disease, maximal transurethral resection followed by radiotherapy and possibly chemotherapy can offer a valuable alternative to radical surgical approaches. A wide variety of planning, dosing, and actual therapy techniques is nowadays available. A challenge in radiotherapy for bladder cancer is caused by organ motion, which limits the precision of radiotherapy for bladder cancer. New treatment techniques and tools for image guidance and adaptive radiotherapy increase precision of dose delivery together with a substantial reduction of treatment volumes. Further investigations toward defining optimal fractionation schemes, techniques, and systemic agents remain to be continued. The development of new diagnostic tools utilizing molecular markers is being explored to further individualize the treatments to the patient with his/her specific tumor characteristics.


Bladder Cancer Planning Target Volume Bladder Tumor Radical Cystectomy Bladder Wall 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Abraham R, Pagano F, Gomella LG et al (2007) Chromosomal deletions in bladder cancer: shutting down pathways. Front Biosci 12:826–838PubMedGoogle Scholar
  2. Advanced Bladder Cancer Meta-analysis Collaboration (2005) Neoadjuvant chemotherapy in invasive bladder cancer: update of a systematic review and meta-analysis of individual patient data. Eur Urol 48:202–206Google Scholar
  3. Awwad H, Abd El, Baki HAEl et al (1979) Preoperative irradiation of T3 carcinoma in bilharzial bladder. A comparison between hyperfractionation and conventional fractionation. Int J Radiat Oncol Biol Phys 5:787–794PubMedGoogle Scholar
  4. Barentsz JO, Jager GJ, van Vierzen PB et al (1996) Staging urinary bladder cancer after transurethral biopsy: value of fast dynamic contrast-enhanced MR imaging. Radiology 201:185–193PubMedGoogle Scholar
  5. Barentsz JO, Jager GJ, Witjes JA (2000) MR imaging of the urinary bladder. Magn Reson Imaging Clinic North Am 8:853–867Google Scholar
  6. Batata MA, Chu FCH, Hilaris BS et al (1981) Pre-operative whole pelvis versus true pelvis irradiation and/or cystectomy for bladder cancer. Int J Radiat Oncol Biol Phys 7:1349–1355PubMedGoogle Scholar
  7. Battermann JJ, Tierie AH (1986) Results of implantation for T1 and 2 bladder tumors. Radiother Oncol 5:85–90PubMedGoogle Scholar
  8. Birkenhake S, Leykamm S, Martus P, Sauer R (1999) Concomitant radiochemotherapy with 5-FU and cisplatin for invasive bladder cancer. Acute toxicity and first results. Strahlenther Onkol 175:97–101PubMedGoogle Scholar
  9. Blandy JP, England HR, Evans SJW et al (1980) T3 bladder cancer, the case for salvage cystectomy. Br J Urol 52:502–506Google Scholar
  10. Blank LECM, Koedooder K, van Os R et al (2007) Results of bladder-conserving treatment, consisting of bracytherapy combined with limited surgery and external beam radiotherapy, for patients with solitary T1–T3 bladder tumors less than 5 cm in diameter. Int J Radiat Oncol Biol Phys 69:454–458PubMedGoogle Scholar
  11. Bloom JJG, Hendry WF, Wallace DM et al (1982) Treatment of T3 bladder cancer: controlled trial of pre-operative radiotherapy and radical cystectomy versus radical radiotherapy. Second report and review (for the Clinical Trials Group, Institute of Urology). Br J Urol 11:136–151Google Scholar
  12. Brannan W, Ochsner MG, Fuselier HA Jr et al (1978) Partial cystectomy in the treatment of transitional cell carcinoma of the bladder. J Urol 119:213–215PubMedGoogle Scholar
  13. Breur K (1956) Radiotherapy of bladder carcinoma. Ned Tijdschr Geneeskd 100:1053–1062PubMedGoogle Scholar
  14. Brown FM (2000) Urine cytology. It is still the gold standard for screening? Urol Clin North Am 27:25–37PubMedGoogle Scholar
  15. Budman LI, Kassouf W, Steinberg JR (2008) Biomarkers for detection and surveillance of bladder cancer. Can Urol Assoc J 2:212–221PubMedGoogle Scholar
  16. Burridge N, Amer A, Marchant T (2006) Online adaptive radiotherapy of the bladder: small bowel irradiated-volume reduction. Int J Radiat Oncol Biol Phys 66:892–897PubMedGoogle Scholar
  17. Cervak J, Cufer T, Kragelj B (1993) Sequential transurethral surgery, multiple drugs, and radiation therapy for invasive bladder carcinoma. Int J Radiat Oncol Biol Phys 25:777–782Google Scholar
  18. Chai X, van Herk M, van de Kamer JB et al (2010) Behavior of lipiodol markers during image guided radiotherapy of bladder cancer. Int J Radiat Oncol Biol Phys 77:309–314PubMedGoogle Scholar
  19. Charkravarti A, Winter K, Wu Cl et al (2005) Expression of epidermal growth factor receptor and Her-2 are predictors of favorable outcome and reduced complete response rates, respectively, in muscle-invading gladder cancers treated by concurrent radiation and cisplatin-based chemotherapy: a report from the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 62:309–317Google Scholar
  20. Cheng L, Weaver AL, Neumann RM et al (1999) Substaging of T1 bladder carcinoma based on the depth of invasion as measured by micrometer: a new proposal. Cancer 86:1035–1043PubMedGoogle Scholar
  21. Chow NH, Chan SH, Tzai TS et al (2001) Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder. Clin Cancer Res 7:1957–1962PubMedGoogle Scholar
  22. Chung PW, Bristow RG, Milosevic MF et al (2007) Long-term outcome of radiation-based conservation therapy for invasive bladder cancer. Urol Oncol 25:303–309PubMedGoogle Scholar
  23. Cole D, Durrant K, Robert J et al (1992) A pilot study of accelerated fractionation in the radiotherapy of invasive carcinoma of the bladder. Br J Radiol 65:792–798PubMedGoogle Scholar
  24. Cookson MS (2005) The surgical management of muscle invasive bladder cancer: a contemporary review. Semin Radiat Oncol 15:10–18PubMedGoogle Scholar
  25. Coppin CM, Gospodarowicz MK, James K, Tannock IF, Zee B, Carson J, Pater J, Sullivan LD (1996) Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 14(11):2901–2907PubMedGoogle Scholar
  26. Cowan RA, McBain CA, Ryder WD (2004) Radiotherapy for muscle-invasive carcinoma of the bladder: results of a randomized trial comparing conventional whole bladder with dose-escalated partial bladder radiotherapy. Int J Radiat Oncol Biol Phys 59:197–207PubMedGoogle Scholar
  27. Danesi DT, Arcangeli G, Cruciani E et al (2004) Conservative treatment of invasive bladder carcinoma by transurethral resection, protracted intravenous infusion chemotherapy, and hyperfractionated raiotherapy: long term results. Cancer 101:2540–2548PubMedGoogle Scholar
  28. de Crevoisier R, Ammor A, Court B et al (2004) Bladder-conserving surgery and interstitial brachytherapy for lymph node negative transitional cell carcinoma of the urinary bladder: results of a 28-year single institution experience. Radiother Oncol 72:147–157PubMedGoogle Scholar
  29. Devita J, Hellman S, Rosenberg S (1989) Cancer principles and practice of oncology, 3rd edn edn. Lippincott, Philadelphia, pp 361–362Google Scholar
  30. DeWeerd JH, Colby MY Jr (1973) Bladder carcinoma treated by irradiation and surgery: interval report. J Urol 109:409–413PubMedGoogle Scholar
  31. Drago JR, Rohner TJ Jr (1983) Bladder cancer: results of radical cystectomy for invasive and recurrent superficial tumors. J Urol 130:460–462PubMedGoogle Scholar
  32. Drieskens O, Oyen R, Van Poppel H et al (2005) FDG-PET for preoperative staging of bladder cancer. Eur J Nucl Med Mol Imaging 32:1412–1417PubMedGoogle Scholar
  33. Duncan W, Quilty PM (1986) The results of a series of 963 patients with transitional cell carcinoma of the bladder primarily treated by radical megavoltage X-ray therapy. Radiother Oncol 7:299–310PubMedGoogle Scholar
  34. Dunst J, Saur R, Schrott KM et al (1994) An organ-sparing treatment of advanced bladder cancer: a 10 year experience. Int J Radiat Oncol Biol Phys 30:261–266PubMedGoogle Scholar
  35. Eapen L, Stewart D, Danjoux C et al (1989);Intraarterial cisplatin and concurrent radiation for locally advanced bladder cancer. J Clin Oncol 7:230–235PubMedGoogle Scholar
  36. Edge SB, Byrd DR, Compton CC et al (eds) (2010) Urinary bladder. AJCC Cancer Staging Manual, 7th edn. Springer, New York pp 497–502Google Scholar
  37. Edsmyr F, Anderson L, Eposti PL et al (1985) Irradiation therapy with multiple small fractions per day in urinary bladder cancer. Radiother Oncol 4:197–203PubMedGoogle Scholar
  38. Ferlay J, Parkin DM, Stevliarova-Foucher E (2010) Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer 46:765–781PubMedGoogle Scholar
  39. Fokdal L, Honore H, Hoyer M et al (2004) Impact of changes in bladder and rectal filling volume on organ motion and dose distribution of the bladder in radiotherapy for urinary bladder cancer. Int J Radiat Oncol Biol Phys 59:436–444PubMedGoogle Scholar
  40. Gérard JP, De Laroche G, Ardiet J et al (1985) Iridium curietherapy in conservative treatment of infiltrating cancer of the bladder. J Urol (Paris) 91:139–144Google Scholar
  41. Ghoneim MA, Ashaella AC, Awaad HK et al (1985) Randomized trial of cystectomy with or without pre-operative radiotherapy for carcinoma of the bilharzial bladder. J Urol 134:266–268PubMedGoogle Scholar
  42. Goffinet DR, Schneider MJ, Glatstein EJ et al (1975) Bladder cancer: results of radiation therapy in 384 patients. Radiology 117:149–153PubMedGoogle Scholar
  43. Graham J, Gee A, Hilton S et al (2003) Geometric uncertainties in radiotherapy of the prostate and bladder. In: McKenzie A et al (eds) Geometric uncertainties in radiotherapy. British Institute of Radiology, LondonGoogle Scholar
  44. Greven KM, Solin Hanks GE (1990) Prognostic factors in patients with bladder carcinoma treated with definitive irradiation. Cancer 65:908–912PubMedGoogle Scholar
  45. Greven KM, Spera JA, Solin LJ et al (1992) Local recurrence after cystectomy alone for bladder carcinoma. Cancer 69:2767–2770PubMedGoogle Scholar
  46. Grossman HB, Natale RB, Tangen CM et al (2003) Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. NEJM 349:859–866PubMedGoogle Scholar
  47. Gudjonsson S, Adell L, Merdasa F et al (2009) Should all patients with non-muscle-invasive bladder cancer receive early intravesical chemotherapy after transurethral resection? The results of a prospective randomised multicentre study. Eur Urol 55:773–780PubMedGoogle Scholar
  48. Harland SJ, Kynaston H, Grigor K et al (2007) A randomized trial of radical radiotherapy for the management of pT1G3 NXm0 transitional cell carcinoma of the bladder. J Urol 178:807–813PubMedGoogle Scholar
  49. Herr HW (1987) Conservative treatment of muscle-infiltrating bladder cancer: prospective experience. J Urol 138:1162–1163PubMedGoogle Scholar
  50. Herr HW (2001) Transurethral resection of muscle-invasive bladder cancer: 10-year outcome. J Clin Oncol 19:89–93PubMedGoogle Scholar
  51. Herr HW, Schwalb DM, Zhaang ZF et al (1995) Intravesical bacillus Calmette-Guerin therapy prevents tumor progression and death form superficial bladder cancer. Ten year follow-up of a prospective randomized trial. J Clin Oncol 13:1404–1408PubMedGoogle Scholar
  52. Hirao S, Hirao T, Marsit CJ et al (2005) Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer 104(9):1918–1923PubMedGoogle Scholar
  53. Horwich A, Pendlebury S, Dearnaley DP (1995) Organ conservation in bladder cancer. Eur J Cancer 31(Suppl 5):208Google Scholar
  54. Horwich A, Dearnaley D, Huddart R et al (2005) A randomised trial of accelerated radiotherapy for localised invasive bladder cancer. Radiother Oncol 75:34–43PubMedGoogle Scholar
  55. Housset M, Maulard C, Chretien Y et al (1993) Combined radiation and chemotherapy for invasive transitional-cell carcinoma of the bladder: a prospective study. J Clin Oncol 11:2150–2157PubMedGoogle Scholar
  56. Hulshof MC, van Andel G, Bel A (2007) Intravesical markers for delineation of target volume during external focal irradiation of bladder carcinomas. Radiother Oncol 84:49–51PubMedGoogle Scholar
  57. Huncharek M, Muscat J, Geschwind JF (1998) Planned preoperative radiation therapy in muscle invasive bladder cancer; results of a meta-analysis. Anticancer Res 18:1931–1934PubMedGoogle Scholar
  58. Hussain SA, Stocken DD, Peake DR et al (2004) Long-term results of a phase II study of synchronous chemoradiotherapy in advanced muscle invasive bladder cancer. Br J Cancer 90:2106–2111PubMedGoogle Scholar
  59. Hussain MH, MacVicar GR, Petrylak DP et al (2007) Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trial. J Clin Oncol 25:2218–2224PubMedGoogle Scholar
  60. International collaboration of trialists on behalf of the Medical Research Council Advanced Bladder Cancer Working Party et al (1999) Neoadjuvant cisplatin, methotrexate, and vinblastine chemotherapy for muscle-invasive bladder cancer: a randomised controlled trial. Lancet 354:533–540Google Scholar
  61. Jakse G, Fromhold H, Zurmedden D (1985) Combined radiation and chemotherapy for locally advanced transitional cell carcinoma of the urinary bladder. Cancer 55:1659–1664PubMedGoogle Scholar
  62. James N, Hussain SA (2005) Management of muscle invasive bladder cancer–British approaches to organ conservation. Semin Radiat Oncol 15:19–27PubMedGoogle Scholar
  63. James N, Hussain S, Hall E et al (2010) Results of a 2 × 2 phase III randomized trial of synchronous chemo-radiotherapy compared to radiotherapy alone and standard vs. reduced high volume RT in muscle invasive bladder cancer. Int J Radiat Oncol Biol Phys 78(S1):S2–S3Google Scholar
  64. Jemal A, Siegel R, Xu J, Ward E (2010) Cancer statistics, 2010. CA Cancer J Clin 60:277–300PubMedGoogle Scholar
  65. Jenkins P, Anjarwalla S, Gilbert H, Kinder R (2009) Defining the clinical target volume for bladder cancer radiotherapy treatment planning. Int J Radiat Oncol Biol Phys 75:1379–1384PubMedGoogle Scholar
  66. Johnson DE, Hogan JM, Ayala AG (1972) Primary adenocarcinoma of the urinary bladder. South Med J 65:527–530PubMedGoogle Scholar
  67. Kassouf W, Spiess PE, Siefker-Radtke A et al (2007) Outcome and patterns of recurrence of nonbilharzial pure squamous cell carcinoma of the bladder: a contemporary review of The University of Texas M D Anderson Cancer Center experience. Cancer 110:764–769PubMedGoogle Scholar
  68. Kaufman DS, Winter KA, Shipley WU et al (2009) Phase I-II RTOG study (99–06) of patients with muscle-invasive bladder cancer undergoing transurethral surgery, paclitaxel, cisplatin, and twice-daily radiotherapy follwed by selective bladder preservation or radical cystectomy and adjuvant chemotherapy. Urology 73:833–837PubMedGoogle Scholar
  69. Kausch I, Sommerauer M, Montorsi F et al (2010) Photodynamic diagnosis in non-muscle-invasive bladder cancer: a systematic review and cumulative analysis of prospective studies. Eur Urol 57:595–606PubMedGoogle Scholar
  70. Kuczyk M, Machtens S, Bokemeyer C et al (2002) Surgical bladder preserving strategies in the treatment of muscle-invasive bladder cancer. World J Urol 20:183–189PubMedGoogle Scholar
  71. Lalondrelle S, Huddart R, Warren-Oseni K et al (2010) Adaptive-predictive organ localization using cone-beam computed tomography for improved accuracy in external beam radiotherapy for bladder cancer. Int J Radiat Oncol Biol Phy doi: 10.1016/j.ijrobp.2009.12.003
  72. Latif A, Watters AD, Dunn I et al (2003) HER2/neu overexpression in the development of muscle-invasive transitional cell carcinoma of the bladder. Br J Cancer 89:1305–1309PubMedGoogle Scholar
  73. Lotz HT, Pos FJ, Hulshof MC et al (2006) Tumor motion and deformation during external radiotherapy of bladder cancer. Int J Radiat Oncol Biol Phys 64:1551–1558PubMedGoogle Scholar
  74. Majewski W, Maciejewski B, Majewski S et al (2004) Clinical radiobiology of stage T2–T3 bladder cancer. Int J Radiat Oncol Biol Phys 60:60–70PubMedGoogle Scholar
  75. Mangar S, Thompson A, Miles E (2007) A feasibility study of using gold seeds as fiducial markers for bladder localization during radical radiotherapy. Br J Radiol 80:279–283PubMedGoogle Scholar
  76. Mangar SA, Miller NR, Khoo VS (2008) Evaluating inter-fractional changes in volume and position during bladder radiotherapy and the effect of volume limitation as a method of reducing the internal margin of the planning target volume. Clin Oncol (R Coll Radiol) 20:698–704Google Scholar
  77. Marks LB, Carroll PR, Dugan TC (1995) The response of the urinary bladder, urethra, and ureter to radiation and chemotherapy. Int J Radiat Oncol Biol Phys 31:1257–1280PubMedGoogle Scholar
  78. Marshall VF (1952) The relation of the preoperative estimate to the pathologic demonstration of the extent of vesical neoplasms. J Urol 68:714–723PubMedGoogle Scholar
  79. Marshall VF, McCarron JP Jr (1977) The curability of vesical cancer: greater no or then? Cancer Res 37:2753–2755PubMedGoogle Scholar
  80. Matsumoto K, Kakizoe T, Mikuriya S et al (1981) Clinical evaluation of intraoperative radiotherapy for carcinoma of the urinary bladder. Cancer 47:509–513PubMedGoogle Scholar
  81. Mazeron JJ, Crook J, Chopin D et al (1988) Conservative treatment of bladder carcinoma by partial cystectomy and interstitial iridium 192. Int J Radiat Oncol Biol Phys 15:1323–1330PubMedGoogle Scholar
  82. McBain CA, Green MM, Stratford J (2009a) Ultrasound Imaging to assess inter- and intra-fraction motion during bladder radiotherapy and its potential as a verification tool. Clin Oncol (R Coll Radiol) 21:385–393Google Scholar
  83. McBain CA, Khoo VS, Buckley DL et al (2009b) Assessment of bladder motion for clinical radiotherapy practice using cine-magnetic resonance imaging. Int J Radiat Oncol Biol Phys 75:664–671Google Scholar
  84. Meijer GJ, Rasch C, Remeijer P et al (2003) Three-dimensional analysis of delineation errors, setup errors, and organ motion during radiotherapy of bladder cancer. Int J Radiat Oncol Biol Phys 55:1277–1287PubMedGoogle Scholar
  85. Michalski JM, Gay H, Jackson A et al (2010) Radiation dose-volume effects in radiation-induced rectal injury. Int J Radiat Oncol Biol Phys 76:S123–S129PubMedGoogle Scholar
  86. Millán-Rodriguez F, Chéchile-Toniolo G, Salvador-Bayarri J et al (2000) Primary superficial bladder cancer risk gropus according to progression mortality and recurrence. J Uro 164(3 Pt1):680–684Google Scholar
  87. Miralbell R, Nouet P, Rouzaud M et al (1998) Radiotherapy of bladder cancer: relevance of bladder volume changes in planning boost treatment. Int J Radiat Oncol Biol Phys 41:741–746PubMedGoogle Scholar
  88. Montie JE, Straffon RA, Stewart BH (1984) Radical cystectomy without radiation therapy for carcinoma of the bladder. J Urol 131:477–482PubMedGoogle Scholar
  89. Morabito RA, Kandzari SJ, Milam DF (1979) Invasive bladder carcinoma treated by radical cystecomy: survival of patients. Urology 14:478–481PubMedGoogle Scholar
  90. Morrison AS, Cole P (1976) Epidemiology of bladder cancer. Urol Clin North Am 3:13–29PubMedGoogle Scholar
  91. Mostofi FK, Davis CJ Jr, Sesterhenn IA (1988) Pathology of tumors of the urinary tract. In: Skinner DG, Lieskovskky G (eds) Diagnosis and management of genitourinary cancer. Saunders, Philadelphia, pp 83–117Google Scholar
  92. Muren LP, Smaaland R, Dahl O et al (2003) Organ motion, set-up variation and treatment margins in radical radiotherapy of urinary bladder cancer. Radiother Oncol 69:291–304PubMedGoogle Scholar
  93. Muren LP, Redpath AT, McLaren D et al (2006) A concomitant tumour boost in bladder irradiation: patient suitability and the potential of intensity-modulated radiotherapy. Radiat Oncol 80:98–105Google Scholar
  94. Muren LP, Redpath AT, Lord H (2007) Image-guided radiotherapy of bladder cancer: bladder volume variation and its relation to margins. Radiother Oncol 84:307–313PubMedGoogle Scholar
  95. Natale RB, Grossman HB, Blumenstein BB et al (2001) SWOG 8710 (INT-00800): randomized phase III trial of neoadjuvant MVAC plus cystectomy versus cystectomy alone in patients with locally advanced bladder cancer. Proc Am Soc Clin Oncol 20:2a (abstract 3)Google Scholar
  96. Neal DE, Sharples L, Smith K et al (1990) The epidermal growth factor receptor and the prognosis of bladder cancer. Cancer 65:1619–1625PubMedGoogle Scholar
  97. Ng CS (2006) Radiologic diagnosis and staging of renal and bladder cancer. Semin Roentgenol 41:121–138PubMedGoogle Scholar
  98. Nguyen PL, Swanson PE, Jaszcz W et al (1994) Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis. Am J Clin Pathol 101:166–176PubMedGoogle Scholar
  99. Nieuwenhuizen JA, Pos F, Moonen LMF et al (2005) Survival after bladder-preservation with brachytherapy versus radical cystectomy; a single institution experience. Eur Urol 48:239–245Google Scholar
  100. Nix J, Smith A, Kurpad R et al (2010) Prospective randomized controlled trial of robotic versus open radical cystectomy for bladder cancer: perioperative and pathologic results. Eur Urol 57:196–201PubMedGoogle Scholar
  101. Nixon RG, Chang SS, Lafleur BJ et al (2002) Carcinoma in situ and tumor multifocality predict the risk of prostatic urethral involvement at radical cystectomy in men with transitional cell carcinoma of the bladder. J Urol 167:502–505PubMedGoogle Scholar
  102. Oosterlinck W, Kurth KH, Schroder F et al (1993) A prospective European organization for research and treatment of cancer genitourinary group randomized trial comparing transurethral resection followed by a single intravescial installation of epirubicin or water in a single stage Ta, T1 papillary carcinoma of the bladder. J Urol 149:749–752PubMedGoogle Scholar
  103. Paik ML, Scolieri MJ, Brown SL et al (2000) Limitations of computerized tomography in staging invasive bladder cancer before radical cystectomy. J Uro 163:1693–1696Google Scholar
  104. Parsons JT, Million RR (1988) Planned preoperative irradiation in the management of clinical stage B2-C (T3) bladder carcinoma. Int J Radiat Oncol Biol Phys 14:797–810PubMedGoogle Scholar
  105. Pearse HD (1994) The urinary bladder. In: Cox JD (ed) Moss’ radiation oncology: rationale, technique results. Mosby, St Louis, p 5222Google Scholar
  106. Peeters ST, Lebesque JV, Heemsbergen WD et al (2006) Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys 64:1151–1161PubMedGoogle Scholar
  107. Pernot M, Hubert J, Guillemin F et al (1996) Combined surgery and brachytherapy in the treatment of some cancers of the bladder (partial cystectomy and interstitial iridium-192). Radiother Oncol 38:115–120PubMedGoogle Scholar
  108. Piet AH, Hulshof MC, Pieters BR et al (2008) Clinical results of a concomitant boost radiotherapy technique for muscle-invasive bladder cancer. Strahlenther Onkol 184:313–318PubMedGoogle Scholar
  109. Pollack A, Zagars GK, Swanson DA (1994) Muscle-invasive bladder cancer treated with external beam radiotherapy: prognostic factors. Int J Radiat Oncol Biol Phys 30:267–277PubMedGoogle Scholar
  110. Poortmans PM, Richaud P, Collette L, Ho Goey S, Pierart M, Van Der Hulst M, Bolla M, On behalf of the EORTC Radiation Oncology Group (2008) Results of the phase II EORTC 22971 trial evaluating combined accelerated external radiation and chemotherapy with 5FU and cisplatin in patients with muscle invasive transitional cell carcinoma of the bladder. Acta Oncol 47:937–940PubMedGoogle Scholar
  111. Pos FJ, Koedooder K, Hulshof MC et al (2003) Influence of bladder and rectal volume on spatial variability of a bladder tumor during radical radiotherapy. Int J Radiat Oncol Biol Phys 55:835–841PubMedGoogle Scholar
  112. Pos FJ, Horenblas S, Lebesque J et al (2004) Low-dose-rate brachytherapy is superior to high-dose-rate brachytherapy for bladder cancer. Int J Radiat Oncol Biol Phys 59:696–705PubMedGoogle Scholar
  113. Pos FJ, Hulshof M, Lebesque J et al (2006a) Adaptive radiotherapy for invasive bladder cancer: a feasibility study. Int J Radiat Oncol Biol Phys 64:862–868PubMedGoogle Scholar
  114. Pos FJ, Hart G, Schneider C, Sminia P (2006b) Radical radiotherapy for invasive bladder cancer: what dose and fractionation schedule to choose? Int J Radiat Oncol Biol Phys 64:1168–1173PubMedGoogle Scholar
  115. Pos F, Bex A, Dees-Ribbers HM et al (2009) Lipiodol injection for target volume delineation and image guidance during radiotherapy for bladder cancer. Radiother Oncol 93:364–367PubMedGoogle Scholar
  116. Quilty PM, Duncan W (1986) Primary radical radiotherapy for T3 transitional cell cancer of the bladder: an analysis of survival and control. Int J Radiat Oncol Biol Phys 12:853–860PubMedGoogle Scholar
  117. Radosevic-Jelic L, Pekmezovic T, Pavlovic-Cvetkovic L et al (1999) Concomitant radiotherapy and carboplatin in locally advanced bladder cancer. Eur Urol 36:401–405PubMedGoogle Scholar
  118. Redpath AT, Muren LP (2006) CT-guided intensity modulated radiotherapy for bladder cancer: isocentre shifts, margins and their impact on target dose. Radiat Oncol 81:276–283Google Scholar
  119. Reibischung JL, Vannetjel ZM, Fournier F (1992) Cyclic concomitant chemoradiotherapy for invasive bladder cancer. Phase I study with organ preservation. Proc Am Soc Clin Oncol 11:208Google Scholar
  120. Resnick MI, O’Conor VJ Jr (1972) Segmental resection for carcinoma of the bladder: review of 102 patients. J Urol 109:1007–1010Google Scholar
  121. Richards B, Bastabla JR, Freedman L et al (1983) Adjuvant chemotherapy in T3NxMo bladder cancer treated with radiotherapy. Br J Urol 55:386–391PubMedGoogle Scholar
  122. Richie JP, Skinner DG, Kaufman JJ (1975) Radical cystectomy for carcinoma of the bladder: 16 years of experience. J Urol 113:186–189PubMedGoogle Scholar
  123. Rodel C, Weiss C, Sauer R (2005) Organ preservation by combined modality treatment in bladder cancer: the European perspective. Semin Radiat Oncol 15:28–35PubMedGoogle Scholar
  124. Rödel C, Grabenbauer GG, Kühn R et al (2002) Organ preservation in patients with invasive bladder cancer: initial results of an intensified protocol of transurethral surgery and radiation therapy plus concurrent cisplatin and 5-fluorouracil. Int J Radiat Oncol Biol Phys 52:1303–1309PubMedGoogle Scholar
  125. Rothwell RI, Ash DV, Jones WG (1983) Radiation treatment planning for bladder cancer: a comparison of cystogram localization with computed tomography. Clin Radiol 34:103–111PubMedGoogle Scholar
  126. Rotman M, Macchia R, Silverstein R et al (1987) Treatment of advanced bladder cancer with irradiation and 5 fluorouracil infusion. Cancer 59:710–714PubMedGoogle Scholar
  127. Rotman M, Aziz H, Porrazo M et al (1990) Treatment of advanced transitional cell carcinoma of the bladder with irradiation and concomitant 5-FU infusion. Int J Radiat Oncol Phys 18:1131–1137Google Scholar
  128. Rozan R, Alubuisson E, Donnareix D et al (1992) Interstitial iridium-192 for bladder cancer (a multicentric survey: 205 patients). Int J Radiat Oncol Biol Phys 24:469–477PubMedGoogle Scholar
  129. Russell KJ, Boileau MA, Higano C et al (1990) Combined 5-fluorouracil and irradiation for transitional cell carcinoma of the urinary bladder. Int J Radiat Oncol Biol Phys 19:693–699PubMedGoogle Scholar
  130. Sabaa MA, El-Gamal OM, Abo-Elenen M, Khanam A (2010) Combined modality treatment with bladder preservation for muscle invasive bladder cancer. Urol Oncol 28:14–20PubMedGoogle Scholar
  131. Sauer R, Dunst J, Altendorf-Hofmann A et al (1990) Radiotherapy with and without cisplatin in bladder cancer. Int J Radiat Oncol Biol Phys 19:687–691PubMedGoogle Scholar
  132. Sauer R, Birkenhake S, Kühn R et al (1998) Efficacy of radiochemotherapy with platin derivatives compared to radiotherapy alone in organ-sparing treatment of bladder cancer. Int J Radiat Oncol Biol Phys 40:121–127PubMedGoogle Scholar
  133. Scholten AN, Leer JW, Collins CD et al (1997) Hypofractionated radiotherapy for invasive bladder cancer. Radiother Oncol 43:163–169PubMedGoogle Scholar
  134. Shariat SF, Tokunaga H, Zhou J et al (2004) P53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. J Clin Onco 22:1014–1024Google Scholar
  135. Shelley MD, Kynaston H, Court J et al (2001) A systematic review of intravesical bacillus Calmette-Guérin plus transurethral resection vs transurethral resection alone in Ta and T1 bladder cancer. BJU Int 88:209–216PubMedGoogle Scholar
  136. Shelley MD, Mason MD, Kynaston H (2010) Intravesical therapy for superficial bladder cancer: a systematic review of randomised trials and meta-analyses. Cancer Treat Rev 36:195–205PubMedGoogle Scholar
  137. Shipley WU, Rose MA, Perrone TL et al (1985) Full dose irradiation for patients with invasive bladder carcinoma. Clinical and histologic factors prognostic of improved survival. J Urol 134:679–683PubMedGoogle Scholar
  138. Skinner DG, Tift JP, Kaufman JJJ (1982) High dose, short course preoperative radiation therapy and immediate single stage radical cystectomy with pelvic node dissection in the management of bladder cancer. J Urol 127:671PubMedGoogle Scholar
  139. Smaaland R, Aksle A, Tonder B, Mehus A, Lote K, Albreksten G (1991) Radical radiation treatment of invasive and locally advanced bladder carcinoma in elderly patients. Br J Urol 67:61–69PubMedGoogle Scholar
  140. Soloway MS, Sofer M, Vaidya A (2002) Contemporary management of stage T1 Transitional cell carcinoma of the bladder. J Urol 167:1573–1583PubMedGoogle Scholar
  141. Solsona E, Iborra I, Ricos JV et al (1992) Feasibility of transurethral resection for muscle-infiltrating carcinoma of the bladder: prospective study. J Urol 147:1513–1515PubMedGoogle Scholar
  142. Sondergaard J, Hoyer M, Petersen JB et al (2009) The normal tissue sparing obtained with simulatenous treatment of pelvic lymph nodes and bladder using intensity-modulated radiotherapy. Acta Oncol 48:238–244PubMedGoogle Scholar
  143. Søndergaard J, Olsen KO, Muren LP et al (2010) A study of image-guided radiotherapy of bladder cancer based on lipiodol injection in the bladder wall. Acta Oncol 49:1109–1115PubMedGoogle Scholar
  144. Swinnen G, Maes A, Pottel H et al (2010) FDG-PET/CT for the preoperative lymph node staging of invasive bladder cancer. Eur Urol 57:641–647PubMedGoogle Scholar
  145. Sylvester RJ, Oosterlinck W, van der Meijden AP (2004) A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: a meta-analysis of pulbished results of randomized clinical trials. J Urol 171(6ptl):2186–2190PubMedGoogle Scholar
  146. Sylvester RJ, van der Meijden AP, Oosterlinck W et al (2006) Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol 49:466–475PubMedGoogle Scholar
  147. Tester W, Porter A, Asbell S et al (1993) Combined modality program with possible organ preservation for invasive bladder cancer: results of RTOG protocol 85–12. Int J Radiat Oncol Biol Phys 25:783–790PubMedGoogle Scholar
  148. Tester W, Caplan R, Heaney J et al (1996) Neoadjuvant combined modality program with selective organ preservation for invasive bladder cancer: results of Radiation Therapy Oncology Group phase II trial 8802. J Clin Oncol 14:119–126PubMedGoogle Scholar
  149. Timmer PR, Hartlief HA, Hooijkass JAP (1985) Bladder cancer: pattern of recurrence in 142 patients. Int J Radiat Oncol Biol Phys 11:899–905PubMedGoogle Scholar
  150. Tolley DA, Parmar MKB, Grigor KM et al (1996) The effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer: a further report with 7 years of followup. J Urol 155:1233–1238PubMedGoogle Scholar
  151. Urist MJ, Di Como CJ, Lu ML et al (2002) Loss of p63 expression is associated with tumor progression in bladder cancer. Am J Pathol 161(4):1199–1206PubMedGoogle Scholar
  152. Vale JA, A’hern Liu K et al (1993) Predicting the outcome of radical radiotherapy for invasive bladder cancer. Eur Urol 24(24):48–51PubMedGoogle Scholar
  153. van der Steen-Banasik EM, Ploeg M, Witjes JA et al (2009) Brachytherapy versus cystectomy in solitary bladder cancer: a case control, multicentre, East-Netherlands study. Radiother Oncol 93:352–357PubMedGoogle Scholar
  154. Van der Werf-Messing B, Hop WCJ (1981) Carcinoma of the urinary bladder (category T1NxMO) treated either by radium implant or by transurethral resection only. Int J Radiat Oncol Biol Phys 7:299–303PubMedGoogle Scholar
  155. van der Werf-Messing B, van Putten W (1989) Carcinoma of the urinary bladder category T2, 3NxM0 treated by 40 Gy external irradiation followed by Caesium 137 implant at reduced dose (50%). Int J Radiat Oncol Biol Phys 16:369–371PubMedGoogle Scholar
  156. Van der Werf-Messing B, Menon RS, Hop WCJ (1983a) Cancer of the urinary bladder category T2, T3 (NxMo) treated by interstitial radium implant: second report. Int J Radiat Oncol Biol Phys 9:481–485Google Scholar
  157. van der Werf-Messing B, Menon RS, Hop WC (1983b) Carcinoma of the urinary bladder category T3NxM0 treated by the combination of radium implant and external irradiation: second report. Int J Radiat Oncol Biol Phys 9:177–180Google Scholar
  158. Van Limbergen E, Mazeron JJ (2002) Urinary bladder cancer. In: Gerbaulet A, Pötter R, Mazeron JJ, Meertens H, Van Limbergen E (eds) The GEC ESTRO handbook of brachytherapy. Leuven, ESTRO, pp 457–469Google Scholar
  159. van Onna IE, Oddens JR, Kok ET et al (2009) External beam radiation therapy followed by interstitial radiotherapy with iridium-192 for solitary bladder tumours: results of 111 treated patients. Eur Urol 56:113–122PubMedGoogle Scholar
  160. van Rooijen DC, Pool R, van de Kamer JB et al (2010) Independent position correction on tumor and lymph nodes; consequences for bladder cancer irradiation with two combined IMRT plans. Radiat Oncol 5:53–60PubMedGoogle Scholar
  161. van’t Riet A, Mak AC, Moerland MA et al (1997) A conformation number to quantify the degree of conformality in brachytherapy and external beam irradiation: application to the prostate. Int J Radiat Oncol Biol Phys 37:731–736Google Scholar
  162. Viswanathan AN, Yorke ED, Marks LB et al (2010) Radiation dose-volume effects of the urinary bladder. Int J Radiat Oncol Biol Phys 76:S116–S122PubMedGoogle Scholar
  163. Weiss C, Ewolze C, Engehausen DG et al (2006) Radiochemotherapy after transurethral resection for high-risk T1 bladder cancer: an alternative to intravesical therapy or early cystectomy? J Clin Oncol 24:2318–2324PubMedGoogle Scholar
  164. Whitmore WF Jr, Batata MA, Ghoneim MA et al (1977a) Radical cystectomy with or without prior radiation in the treatment of bladder cancer. Gen Urol 188:184–187Google Scholar
  165. Whitmore WF Jr, Batata MA, Ghoneim MA et al (1977b) Radical cystectomy with or without prior radiation in the treatment of bladder cancer. J Urol 118:184–187PubMedGoogle Scholar
  166. Woehere H, Ous S, Klevmark B et al (1993) A bladder cancer multi-institutional experience with total cystectomy for muscle-invasive bladder cancer. Cancer 72:3044–3051Google Scholar
  167. Wood DP Jr, Montie JE, Pontes JE et al (1989) Transitional cell carcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer. J Urol 141:346–349PubMedGoogle Scholar
  168. Wszolek MF, Rieger-Christ KM, Kenney PA et al (2009) A microRNA expression profile defining the invasive bladder tumor phenotype. Urol Onco. In press, [Epub ahead of print] 27 Nov 2009Google Scholar
  169. Yavuz AA, Yavuz MN, Ozgur GK et al (2003) Accelerated superfractionated radiotherapy with concomitant boost for invasive bladder cancer. Int J Radiat Oncol Biol Phys 56:734–745PubMedGoogle Scholar
  170. Zietman AL, Hunt D, Kaufman DS et al (2010) Preliminary results of RTOG 0233: a phasee II randomized trial for muscle-inading bladder cancer treated by transuretrhal resection and radiotherapy comparing two forms of concurrent induction chemotherapy. Int J Radiat Oncol Biol Phys 78:S31–S32Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Peter Han
    • 1
  • Marvin Rotman
    • 1
  • Alan R. Schulsinger
    • 1
    • 2
  • Bradley R. Pieters
    • 3
  • Caro C. E. Koning
    • 3
  • Floris J. Pos
    • 4
  • Maarten C. C. M. Hulshof
    • 3
  • Philip Poortmans
    • 5
  1. 1.Department of Radiation OncologyState University of New York, Health Science Center at BrooklynBrooklynUSA
  2. 2.Department of Radiation OncologyLong Island College HospitalBrooklynUSA
  3. 3.Department of Radiation OncologyAcademic Medical Center/University of AmsterdamAmsterdamThe Netherlands
  4. 4.Department of Radiation OncologyThe Netherlands Cancer Institute-Antoni van Leeuwenhoek HospitalAmsterdamThe Netherlands
  5. 5.Department of Radiation OncologyInstitute VerbeetenTilburgThe Netherlands

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