Systemic Vasculitis: Anatomy and Histopathology

  • Ahlem Lahmar
  • Sabeh Mzabi-Regaya
  • Samir Boubaker
  • Nidhameddine Kchir
  • Lotfi Hendaoui
Part of the Medical Radiology book series (MEDRAD)


Vasculitides are defined by inflammation of the blood vessel walls leading to vascular stenosis or occlusion, with various degrees of fibrinoid necrosis of the media and inflammatory infiltration, mainly neutrophilic and sometimes granulomatous. Systemic vasculitides are classified according to their clinical presentations, their precise histological features, and the size of the predominantly affected vessels. Some of them are necrotizing: there is fibrinoid necrosis of the media with endothelial inflammatory infiltration and an inflammatory reaction of the adventitia frequently associated with lumen thrombosis. Others are non-necrotizing, and show giant cell infiltration and destruction of the internal elastic lamina. Finally, there are leucocytoclasic vasculitides without giant cell infiltrate or fibrinoid necrosis.


Kawasaki Disease Systemic Vasculitis Polyarteritis Nodosa Crescentic Glomerulonephritis Internal Elastic Lamina 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Ahlem Lahmar
    • 1
  • Sabeh Mzabi-Regaya
    • 1
  • Samir Boubaker
    • 2
  • Nidhameddine Kchir
    • 3
  • Lotfi Hendaoui
    • 4
  1. 1.Medical School of Tunis, Department of PathologyMongi Slim University HospitalSidi DaoudTunisia
  2. 2.Medical School of Tunis, Department of PathologyLa Rabta University HospitalTunisTunisia
  3. 3.Medical School of Tunis, Department of Anatomo-pathologyLa Rabta University HospitalTunisTunisia
  4. 4.Medical School of Tunis, Department of Medical Imaging and Imaging Guided InterventionsMongi Slim University HospitalSidi DaoudTunisia

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