Systemic Vasculitis: Anatomy and Histopathology
Vasculitides are defined by inflammation of the blood vessel walls leading to vascular stenosis or occlusion, with various degrees of fibrinoid necrosis of the media and inflammatory infiltration, mainly neutrophilic and sometimes granulomatous. Systemic vasculitides are classified according to their clinical presentations, their precise histological features, and the size of the predominantly affected vessels. Some of them are necrotizing: there is fibrinoid necrosis of the media with endothelial inflammatory infiltration and an inflammatory reaction of the adventitia frequently associated with lumen thrombosis. Others are non-necrotizing, and show giant cell infiltration and destruction of the internal elastic lamina. Finally, there are leucocytoclasic vasculitides without giant cell infiltrate or fibrinoid necrosis.
KeywordsKawasaki Disease Systemic Vasculitis Polyarteritis Nodosa Crescentic Glomerulonephritis Internal Elastic Lamina
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