High Field MR Spectroscopy: Investigating Human Metabolite Levels at High Spectral and Spatial Resolution

  • Duan Xu
  • Daniel B. Vigneron
Part of the Medical Radiology book series (MEDRAD)


Magnetic Resonance Spectroscopy (MRS) offers a unique window to cellular metabolism through its ability to detect the concentrations of small mobile biological compounds non-invasively. Nevertheless, MRS has failed to broadly enter the clinical routine despite its success in scientific studies. Limitations in sensitivity, spatial resolution, and spectral identification, which can be severe at lower fields, are reduced for ultra-high field MRS allowing unprecedented in vivo studies of cellular metabolite levels at 7 T. In this chapter, the challenges, methods, capabilities, and applications of ultra-high field magnetic resonance spectroscopy are presented. Also included are examples of the unique metabolic information obtained using 7 T MR systems for the study of human cellular metabolite levels in both normal volunteers and patients. High resolution MR spectroscopic imaging has provided improved detection of small brain lesions and enhanced assessment of brain tumor presence and extent. While the majority of MRS research has focused on neurological applications, the increased sensitivity and spectral resolution can improve the metabolic characterization of pathologies in other organs as well.


Magnetic Resonance Spectroscopy Magnetic Resonance Spectroscopy Study Outer Volume Suppression Order Shim Breast Magnetic Resonance Spectroscopy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Radiology and Biomedical Imaging, MC 2512University of CaliforniaSan FranciscoUSA

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