Locally recurrent breast cancer occurs in 5–15% of patients after breast conservation therapy and after mastectomy with adjuvant radiotherapy. Ipsilateral breast recurrences may be salvaged with mastectomy, however, outcomes from repeat breast conserving surgery and breast re-irradiation is promising. Chest wall recurrence generally portends a worse prognosis than in-breast local recurrences. A subset of patients may be long-term survivors in the absence of metastasis. Persistent chest wall disease can be symptomatic, and in previously irradiated patients, treatment options are limited. Experiences with chest wall re-irradiation have shown excellent response rates with acceptable late toxicity, but follow-up is limited.
KeywordsChest Wall Planning Target Volume Complete Response Rate Breast Conservation Surgery Accelerate Partial Breast Irradiation
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