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Disorders of Sex Development

  • Justin H. Davies
  • Pat S. Malone
  • Jo Fairhurst
Part of the Medical Radiology book series (MEDRAD)

Abstract

The contribution of imaging in disorders of sex development is not confined to the diagnosis of the underlying condition. Imaging has an important role in assisting pre-operative planning where surgery is contemplated, in identifying the location of occult gonads and in assessment of suspected complications of these conditions, including malignant transformation. In each of these scenarios, close collaboration with paediatric endocrinologists and paediatric surgeons is essential if an appropriate management strategy is to be adopted, as imaging is of greatest value where the radiologist is aware of the context in which it is performed.

Keywords

Congenital Adrenal Hyperplasia Gonadal Dysgenesis Urogenital Sinus Wolffian Duct Ambiguous Genitalia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DSD

Disorders of sex development

AMH

Anti-Müllerian Hormone

SRY

Sex determining region of the Y chromosome

AR

Androgen receptor

21-OHD

21-hydroxylase deficiency

AMH

Anti-Müllerian hormone

AMHR

Anti-Müllerian hormone receptor

US

Ultrasound

CT

Computed Tomography

MRI

Magnetic Resonance Imaging

TUM

Total Urogenital Mobilisation

INSL3

Insulin-like 3

T

Testosterone

DHT

Dihydrotestosterone

SF-1

Steroidogenic factor 1

WT-1

Wilm’s tumour-1

SOX-9

SRY box 9

DAX-1

Dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome gene 1

StAR

steroidogenic acute regulatory

LH

Luteinising hormone

TFT

Thyroid function tests

FSH

Follicle stimulating hormone

DHEAS

Dehydroepiandrosterone sulfate

HCG

Human chorionic gonadotropin

MHz

Megahertz

LHRH

Luteinising hormone releasing hormone

17-hydroxy-progesterone

17-OH progesterone

AR

Androgen receptor

MCUG

Micturating Cystourethrogram

PAIS

Partial Androgen Insensitivity Syndrome

AIS

Androgen Insensitivity Syndrome

CAIS

Complete Androgen Insensitivity Syndrome

CAH

Congenital Adrenal Hyperplasia

LGR8

Leucine-rich repeat-containing G-protein-coupled receptor 8

ACTH

Adrenocorticotropic Hormone

GH

Growth hormone

AVP

Arginine vasopressin

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Justin H. Davies
    • 1
  • Pat S. Malone
    • 2
  • Jo Fairhurst
    • 3
  1. 1.Department of Paediatric EndocrinologySouthampton University Hospital TrustSouthamptonUK
  2. 2.Department of Paediatric UrologySouthampton University Hospital TrustSouthamptonUK
  3. 3.Department of Paediatric RadiologySouthampton University Hospital TrustSouthamptonUK

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