Bone Metastases

  • Yvette van der Linden
  • Peter Hoskin
Part of the Medical Radiology book series (MEDRAD)


The treatment of bone metastases comprises a large part of the radiotherapy daily practice. Palliative radiotherapy has proven to be successful in treating pain caused by metastatic lesions in any bone, and in treating neurological complaints caused by compression of the spinal cord due to lesions in the spinal column. In most prospective randomized trials on radiotherapy for bone pain, responses up to 70% were reported. However, when survival was prolonged, recurrent pain was reported in up to 50% of patients. It is to be expected for the future, since patients are living longer with disseminated disease, that symptoms may recur and therefore retreatment of bone metastases for palliative reasons will increase. In this chapter, the evidence-based outcomes for response and duration of response to initial and subsequent radiotherapy will be presented. Guidelines will be formulated for retreatment in bone metastases, with a focus on timing, expected complications and preferred radiotherapy techniques. More intensive radiation techniques like intensity-modulated and stereotactic radiotherapy will be discussed for their possible role in retreatment of bone metastases.


Bone Metastasis Spinal Cord Compression Single Fraction Spinal Metastasis Palliative Radiotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Radiotherapy Institute FrieslandLeeuwardenThe Netherlands
  2. 2.Mount Vernon HospitalNorthwoodUK

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