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Epidemiology, Risk Factors and Clinical Presentation

  • Gabriele Capurso
  • Cesare Hassan
  • Gianfranco Delle Fave
  • Emilio Di Giulio
Chapter
Part of the Medical Radiology book series (MEDRAD)

Abstract

Pancreatic cancer (PDAC) is a deadly disease. It has an incidence ranging 8–12 per 100,000 per year, with a similar mortality, as more than 95% of patients diagnosed with PDAC will ultimately die. Prevention policies are therefore particularly important and they should be distinguished in: (1) Primary prevention, aimed at reducing risk factors for PDAC and possibly favouring protective habits. (2) Secondary prevention, aimed at the early diagnosis through appropriate screening tests in subjects with a particularly high risk. The most important risk factors for pancreatic cancer are family history of pancreatic cancer, smoking, obesity, diabetes, alcohol and chronic pancreatitis. Diabetes of recent onset should be considered a possible alarm symptom. In patients with defined genetic syndromes such as “familiar pancreatic cancer”, and Peutz–Jeghers syndrome screening for pancreatic cancer as a part of research protocols are performed in selected Centres. There are no sufficient data to suggest that vitamins or aspirin may have a role for PDAC chemoprevention.

Keywords

Pancreatic Cancer Chronic Pancreatitis Cystic Fibrosis Transmembrane Conductance Regulator Familial Adenomatous Polyposis PDAC Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Gabriele Capurso
    • 1
  • Cesare Hassan
    • 2
  • Gianfranco Delle Fave
    • 1
  • Emilio Di Giulio
    • 1
  1. 1.Digestive and Liver Disease Unit, II Medical SchoolUniversity “La Sapienza”RomeItaly
  2. 2.Department of Gastroenterology“Nuovo Regina Margherita” HospitalRomeItaly

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