Lung Cancer

  • Branislav Jeremić
  • Francesc Casas
  • Igor Stojkovski
  • Slobodan Milisavljevic
  • Zeljko Dobric
Part of the Medical Radiology book series (MEDRAD)


Local/regional recurrence with or without distant metastases is a common pattern of failure after first-line treatment for lung cancer. It is virtually unknown which proportion of patients initially treated with chest radiotherapy undergo reirradiation during the natural course of the disease. The majority of available studies are retrospective in nature and of limited size. External beam radiation therapy has been used to treat local/regional intrathoracic recurrences after previous radiation therapy for lung cancer, mostly non-small cell histology. In most cases the aim of treatment was palliation of symptoms. However, the increasing availability of new technology such as intensity-modulated and stereotactic radiotherapy has resulted in preliminary data on more aggressive regimens. Endobronchial brachytherapy remains one of the cornerstones of successful palliative approaches in patients with symptomatic endobronchial recurrences of lung cancer. While no established guidelines are available, due to considerable variety in first-line radiation therapy parameters, different planning and retreatment characteristics (including different reirradiation technology used), and lack of validated prognostic factors, current wisdom calls for prudent use of available technology, with clear objectives set upfront.


Lung Cancer Small Cell Lung Cancer Median Survival Time Locoregional Recurrence Primary Lung Cancer 
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  1. Bauman JE, Mulligan MS, Martins RG, Kurland BF, Eaton KD, Wood DE (2008) Salvage lung resection after definitive radiation (>59 Gy) for non-small cell lung cancer: surgical and oncologic outcomes. Ann Thorac Surg 86:1632–1638PubMedCrossRefGoogle Scholar
  2. Beavis AW, Abdel-Hamid A, Upadhyay S (2005) Re-treatment of a lung tumour using a simple intensity-modulated radiotherapy approach. Br J Radiol 78:358–361PubMedCrossRefGoogle Scholar
  3. Becker HP, Radomsky J, Hartel W (1990) Das Rezidiv des nicht-kleinzelligen Bronchialkarzinoms: Indikation und Ergebnisse der chirurgischen Behandlung (German). Pneumologie 44:1106–1109PubMedGoogle Scholar
  4. Bedwinek J, Petty A, Bruton C, Sofield J, Lee L (1991) The use of high dose rate endobronchial brachytherapy to palliate symptomatic endobronchial recurrence of previously irradiated bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 22:23–30CrossRefGoogle Scholar
  5. Cetingoz R, Arikan-Alicikus Z, Nur-Demiral A, Durmak-Isman B, Bakis-Altas B, Kinay M (2009) Is re-irradiation effective in symptomatic local recurrence of non small cell lung cancer patients? A single institution experience and review of the literature. J BUON 14:33–40PubMedGoogle Scholar
  6. Chang JY, Balter PA, Dong L, Yang Q, Liao Z, Jeter M, Bucci MK, McAleer MF, Mehran RJ, Roth JA, Komaki R (2008) Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 72:967–971PubMedCrossRefGoogle Scholar
  7. Coon D, Gokhale AS, Burton SA, Heron DE, Ozhasoglu C, Christie N (2008) Fractionated stereotactic body radiation therapy in the treatment of primary, recurrent, and metastatic lung tumors: the role of positron emission tomography/computed tomography-based treatment planning. Clin Lung Cancer 9:217–221PubMedCrossRefGoogle Scholar
  8. Curran WJ Jr, Herbert SH, Stafford PM, Sandler HM, Rosenthal SA, McKenna WG, Hughes E, Dougherty MJ, Keller S (1992) Should patients with post-resection locoregional recurrence of lung cancer receive aggressive therapy? Int J Radiat Oncol Biol Phys 24:25–30PubMedCrossRefGoogle Scholar
  9. Dartevelle P, Khalif J (1985) Surgical approach to local recurrence and the second primary lesion. In: Delarue NC, Eschapasse H (eds) International trend in general thoracic surgery, vol 1. WB Saunders, Philadelphia, pp 156–163Google Scholar
  10. Delaney G, Barton M, Jacob S, Jalaludin B (2003) A model for decision making for the use of radiotherapy in lung cancer. Lancet Oncol 4:120–128PubMedCrossRefGoogle Scholar
  11. Delclos ME, Komaki R, Morice RC, Allen PK, Davis M, Garden A (1996) Endobronchial brachytherapy with high-dose-rate remote afterloading for recurrent endobronchial lesions. Radiology 201:279–282PubMedGoogle Scholar
  12. Emami B, Graham MV, Deedy M, Shapiro S, Kucik N (1997) Radiation therapy for intrathoracic recurrence of non-small cell lung cancer. Am J Clin Oncol (CCT) 20:46–50CrossRefGoogle Scholar
  13. Estall V, Barton MB, Vinod SK (2007) Patterns of radiotherapy re-treatment in patients with lung cancer: a retrospective, longitudinal study. J Thorac Oncol 2:531–536PubMedCrossRefGoogle Scholar
  14. Faria SL, Menard S, Devic S, Sirois C, Souhami L, Lisbona R, Freeman CR (2008) Impact of FDG-PET/CT on radiotherapy volume delineation in non-small-cell lung cancer and correlation of imaging stage with pathologic findings. Int J Radiat Oncol Biol Phys 70:1035–1038PubMedCrossRefGoogle Scholar
  15. Gabler A, Liebig S (1980) Reoperation for bronchial carcinoma. Thorax 35:668–674PubMedCrossRefGoogle Scholar
  16. Gauwitz M, Ellerbroek N, Komaki R, Putnam JB Jr, Ryan MB, DeCaro L, Davis M, Cundiff J (1992) High dose endobronchial irradiation in recurrent bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 23:397–400PubMedCrossRefGoogle Scholar
  17. Green N, Kern W (1978) The clinical course and treatment results of patients with postresection locally recurrent lung cancer. Cancer 42:2478–2482PubMedCrossRefGoogle Scholar
  18. Green N, Melbye RW (1982) Lung cancer: retreatment of local recurrence after definitive irradiation. Cancer 49:865–868PubMedCrossRefGoogle Scholar
  19. Gressen EL, Werner-Wasik M, Cohn J, Topham A, Curran WJ Jr (2000) Thoracic reirradiation for symptomatic relief after prior radiotherapeutic management for lung cancer. Am J Clin Oncol (CCT) 23:160–163CrossRefGoogle Scholar
  20. Grgic A, Nestle U, Schaefer-Schuler A, Kremp S, Ballek E, Fleckenstein J, Rübe C, Kirsch CM, Hellwig D (2009) Nonrigid versus rigid registration of thoracic 18F-FDG PET and CT in patients with lung cancer: an intraindividual comparison of different breathing maneuvers. J Nucl Med 50:1921–1926PubMedCrossRefGoogle Scholar
  21. Gustafson G, Vicini F, Freedman L, Johnston E, Edmudson G, Sherman S, Pursel S, Komic M, Chen P, Borrego JC, Seidman J, Martinez A (1995) High dose rate endobronchial brachytherapy in the management of primary and recurrent bronchogenic malignancies. Cancer 75:2345–2350PubMedCrossRefGoogle Scholar
  22. Hanna GG, McAleese J, Carson KJ, Stewart DP, Cosgrove VP, Eakin RL, Zatari A, Lynch T, Jarritt PH, Young VA, O’Sullivan JM, Hounsell AR (2010) (18)F-FDG PET-CT simulation for non-small-cell lung cancer: effect in patients already staged by PET-CT. Int J Radiat Oncol Biol Phys 77:24–30PubMedCrossRefGoogle Scholar
  23. Hatlevoll R, Karlsen KO, Skovlund E (1999) Endobronchial radiotherapy for malignant bronchial obstruction or recurrence. Acta Oncol 38:999–1004PubMedCrossRefGoogle Scholar
  24. Hauswald H, Stoiber E, Rochet N, Lindel K, Grehn C, Becker HD, Debus J, Harms W (2010) Treatment of recurrent bronchial carcinoma: the role of high-dose-rate endoluminal brachytherapy. Int J Radiat Oncol Biol Phys 77:373–377PubMedCrossRefGoogle Scholar
  25. Hayakawa K, Mitsuhashi N, Saito Y, Nakayama Y, Furuta M, Sakurai H, Kawashima M, Ohno T, Nasu S, Niibe H (1999) Limited field irradiation for medically inoperable patients with peripheral stage I non-small cell lung cancer. Lung Cancer 26:137–142PubMedCrossRefGoogle Scholar
  26. Hung J-J, Hsu WH, Hsieh C-C, Huang BS, Huang MH, Liu JS, Wu YC (2009) Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence. Thorax 64:192–196PubMedCrossRefGoogle Scholar
  27. Ihde DC, Bilek FS, Cohen MH (1979) Response to thoracic radiotherapy in patients with small cell carcinoma of the lung after failure of combination chemotherapy. Radiology 132:443–446PubMedGoogle Scholar
  28. International Agency for Research on Cancer (IARC) (2010):
  29. Jackson MA, Ball DL (1987) Palliative retreatment of locally recurrent lung cancer after radical radiotherapy. Med J Aust 147:391–394PubMedGoogle Scholar
  30. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics 2009. CA Cancer J Clin 59:225–249PubMedCrossRefGoogle Scholar
  31. Jeremic B, Bamberg M (2002) External beam radiation therapy for bronchial stump recurrence of non-small-cell lung cancer after complete resection. Radiother Oncol 64:251–257PubMedCrossRefGoogle Scholar
  32. Jeremic B, Shibamoto Y, Acimovic LJ, Milisavljevic S (1997) Hyperfractionated radiotherapy alone for clinical stage I nonsmall cell lung cancer. Int J Radiat Oncol Biol Phys 38:521–525PubMedCrossRefGoogle Scholar
  33. Jeremic B, Shibamoto Y, Acimovic LJ, Milisavljevic S (1999a) Hyperfractionated radiotherapy for clinical stage II nonsmall cell lung cancer. Radiother Oncol 51:141–145PubMedCrossRefGoogle Scholar
  34. Jeremic B, Shibamoto Y, Milicic B, Milisavljevic S, Nikolic N, Dagovic A, Aleksandrovic J, Radosavljevic-Asic G (1999b) External beam radiation therapy alone for loco-regional recurrence of non-small-cell lung cancer after complete resection. Lung Cancer 23:135–142PubMedCrossRefGoogle Scholar
  35. Jeremic B, Shibamoto Y, Acimovic L, Nikolic N, Dagovic A, Aleksandrovic J, Radosavljevic-Asic G (2001) Second cancers occurring in patients with early stage non-small cell lung cancer treated with chest radiation therapy alone. J Clin Oncol 19:1056–1063PubMedGoogle Scholar
  36. Kagami Y, Nishio M, Narimatsu N, Mjoujin M, Sakurai T, Hareyama M, Saito A (1998) Radiotherapy for locoregional recurrent tumours after resection of non-small cell lung cancer. Lung Cancer 20:31–35PubMedCrossRefGoogle Scholar
  37. Kawaguchi T, Matsumura A, Iuchi K, Ishikawa S, Maeda H, Fukai S, Komatsu H, Kawahara M (2006) Second primary cancers in patients with stage III non-small cell lung cancer successfully treated with chemo-radiotherapy. Jpn J Clin Oncol 36:7–11PubMedCrossRefGoogle Scholar
  38. Kelly JF, Delclos ME, Morice RC, Huaringa A, Allen PK, Komaki R (2000) High-dose-rate endobrobchial brachytherapy effectively palliates symptoms due to airway tumors: the 10-year M.D. Anderson Cancer Center experience. Int J Radiat Oncol Biol Phys 48:697–702PubMedCrossRefGoogle Scholar
  39. Kono K, Murakami M, Sasaki R (1998) Radiation therapy for non-small cell lung cancer with postoperative intrathoracic recurrence. Nippon Igaku Hoshasen Gakkai Zasshi 58:18–24PubMedGoogle Scholar
  40. Kopelson G, Choi NCH (1980) Radiation therapy for postoperative local-regionally recurrent lung cancer. Int J Radiat Oncol Biol Phys 6:1503–1506PubMedCrossRefGoogle Scholar
  41. Kramer GWPM, Gans S, Ullmann E, van Meerbeck JP, Legrand C, Leer JWH (2004) Hypofractionated external beam radiotherapy as retreatment for symptomatic non-small-cell lung carcinoma: an effective treatment? Int J Radiat Oncol Biol Phys 58:1388–1393PubMedCrossRefGoogle Scholar
  42. Law MR, Henk JM, Lennox SC, Hodson M (1982) Value of radiotherapy for tumour on the bronchial stump after resection of bronchial carcinoma. Thorax 37:496–499PubMedCrossRefGoogle Scholar
  43. Lesser T, Brenner A, Bartel M (1997) Das Rezidiv beim kurativ operierten nicht-kleinzelligen Bronchialkarzinom (German). Zentralbl Chir 122:642–648PubMedGoogle Scholar
  44. Leung J, Ball D, Worotniuk T, Laidlaw C (1995) Survival following radiotherapy for post-surgical locoregional recurrence of non-small cell lung cancer. Lung Cancer 13:121–127PubMedCrossRefGoogle Scholar
  45. MacManus M, Nestle U, Rosenzweig KE, Carrio I, Messa C, Belohlavek O, Danna M, Inoue T, Deniaud-Alexandre E, Schipani S, Watanabe N, Dondi M, Jeremic B (2009) Use of PET and PET/CT for radiation therapy planning: IAEA expert report 2006–2007. Radiother Oncol 91:85–94PubMedCrossRefGoogle Scholar
  46. Martini N, Melamed MR (1975) Multiple primary lung cancers. J Thorac Cardiovasc Surg 70:606–612PubMedGoogle Scholar
  47. Mehta MP, Shahabi S, Jarjour NN, Kinsella TJ (1989) Endobronchial irradiation for malignant airway obstruction. Int J Radiat Oncol Biol Phys 17:847–851PubMedCrossRefGoogle Scholar
  48. Mendiondo OA, Dillon M, Beach LJ (1983) Endobronchial brachytherapy in the treatment of recurrent bronchogenic carcinoma. Int J Radiat Oncol Biol Phys 9:579–582PubMedCrossRefGoogle Scholar
  49. Micke O, Prott FJ, Schäfer U, Wagner W, Pötter R (1995) Endoluminal HDR brachytherapy in the palliative treatment of patients with the recurrence of a non-small-cell bronchial carcinoma after prior radiotherapy. Strahlenther Onkol 171:554–559PubMedGoogle Scholar
  50. Montebello JF, Aron BS, Manatunga AK, Horvath JL, Peyton FW (1993) The reirradiation of recurrent bronchogenic carcinoma with external beam irradiation. Am J Clin Oncol 16:482–488PubMedCrossRefGoogle Scholar
  51. Morita K, Fuwa N, Suzuki Y, Nishio M, Sakai K, Tamaki Y, Niibe H, Chujo M, Wada S, Sugawara T, Kita M (1997) Radical radiotherapy for medically inoperable non-small cell lung cancer in clinical stage I: retrospective analysis of 149 patients. Radiother Oncol 42:31–36PubMedCrossRefGoogle Scholar
  52. Mountain CF (1986) A new international staging system for lung cancer. Chest 89:225S–233SPubMedGoogle Scholar
  53. Naruke T, Goya T, Tsuchiya R, Suemasu K (1988) Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 96:440–447PubMedGoogle Scholar
  54. Neri S, Kitamura J, Komatsu T, Takahashi Y, Tajeshima Y, Kaji R, Hayashi M, Nishimura T, Tomii K, Katakami N, Ishihara K, Kokubo M (2009) Lobectomy for local recurrence following stereotactic radiotherapy to non-small cell lung cancer. Kyobu Geka 62:812–815PubMedGoogle Scholar
  55. Nestle U, Walter K, Schmidt S, Licht N, Nieder C, Motaref B, Hellwig D, Niewald M, Ukena D, Kirsch CM, Sybrecht GW, Schnabel K (1999) 18F-deoxyglucose positron emission tomography (FDG-PET) for the planning of radiotherapy in lung cancer: high impact in patients with atelectasis. Int J Radiat Oncol Biol Phys 44:593–597PubMedCrossRefGoogle Scholar
  56. Nestle U, Kremp S, Grosu AL (2006) Practical integration of [18F]-FDG-PET and PET-CT in the planning of radiotherapy for non-small cell lung cancer (NSCLC): the technical basis, ICRU-target volumes, problems, perspectives. Radiother Oncol 81:209–225PubMedCrossRefGoogle Scholar
  57. Ochs JJ, Tester WJ, Cohen MH, Lichter AS, Ihde DC (1983) Salvage radiation therapy for intrathoracic small cell carcinoma of the lung progressing on combination chemotherapy. Cancer Treat Rep 67:1123–1126PubMedGoogle Scholar
  58. Okamoto Y, Murakami M, Yoden E, Sasaki R, Okuno Y, Nakajima T, Kuroda Y (2002) Reirradiation for locally recurrent lung cancer previously treated with radiation therapy. Int J Radiat Oncol Biol Phys 52:390–396PubMedCrossRefGoogle Scholar
  59. Ono R, Egawa S, Suemasu K, Sakura M, Kitagawa T (1991) Radiotherapy in inoperable stage I lung cancer. Jpn J Clin Oncol 21:125–128PubMedGoogle Scholar
  60. Ornadel D, Duchesne G, Wall P, Ng A, Hetzel M (1997) Defining the roles of high dose rate endobronchial brachytherapy and laser resection for recurrent bronchial malignancy. Lung Cancer 16:203–213PubMedCrossRefGoogle Scholar
  61. Pairolero PC, Williams DE, Bergstralh EJ, Piehler JM, Bernatz PE, Payne WS (1984) Postsurgical stage I bronchogenic carcinoma: morbid implications of recurrent disease. Ann Thorac Surg 38:331–336PubMedCrossRefGoogle Scholar
  62. Poltinnikov IM, Fallon K, Xiao Y, Reiff JE, Curran WJ Jr, Werner-Wasik M (2005) Combination of longitudinal and circimferential three-dimensional esophageal dose distribution predicts acute esophagitis in hypofractionated reirradiation of patients with non-small-cell lung cancer treated in stereotactic body frame. Int J Radiat Oncol Biol Phys 62:652–658PubMedCrossRefGoogle Scholar
  63. Regnard JF, Icard P, Magdeleinat P, Jauffret B, Farés E, Levasseur P (1999) Completion pneumonectomy: experience in eighty patients. J Thorac Cardiovasc Surg 117:1095–1101PubMedCrossRefGoogle Scholar
  64. Riegel AC, Bucci MK, Mawlawi OR, Johnson V, Ahmad M, Sun X, Luo D, Chandler AG, Pan T (2010) Target definition of moving lung tumors in positron emission tomography: correlation of optimal activity concentration thresholds with object size, motion extent, and source-to-background ratio. Med Phys 37:1742–1752PubMedCrossRefGoogle Scholar
  65. Salazar OM, Yee GJ, Slawson RG (1991) Radiation therapy for chest recurrence following induction chemotherapy in small cell lung cancer. Int J Radiat Oncol Biol Phys 21:645–650PubMedCrossRefGoogle Scholar
  66. Schaefer A, Kremp S, Hellwig D, Rübe C, Kirsch CM, Nestle U (2008) A contrast-oriented algorithm for FDG-PET-based delineation of tumour volumes for the radiotherapy of lung cancer: derivation from phantom measurements and validation in patient data. Eur J Nucl Med Mol Imaging 35:1989–1999PubMedCrossRefGoogle Scholar
  67. Seagren SL, Harrell JH, Horn RA (1985) High dose rate intraluminal irradiation in recurrent endobronchial carcinoma. Chest 88:810–814PubMedCrossRefGoogle Scholar
  68. Shaw EG, Brindle JS, Creagan ET, Foote RL, Trastek VF, Buskirk SJ (1992) Locally recurrent non-small-cell lung cancer after complete surgical resection. Mayo Clin Proc 67:1129–1133PubMedGoogle Scholar
  69. Sibley GS, Jamieson TA, Marks LB, Anscher MS, Prosnitz LR (1998) Radiotherapy alone for medically inoperable stage I non-small-cell lung cancer: the Duke experience. Int J Radiat Oncol Biol Phys 40:149–154PubMedCrossRefGoogle Scholar
  70. Sutedja G, Baris G, Schaake-Koning C, van Zandwijk N (1992) High dose rate brachytherapy in patients with local recurrences after radiotherapy of non-small cell lung cancer. Int J Radiat Oncol Biol Phys 24:551–553PubMedCrossRefGoogle Scholar
  71. Suzuki T, Horio H, Sakaguchi K, Yamamoto M (2007) Lobectomy for local recurrence of lung cancer after 3-dimensional-conformal radiotherapy. Kyobu Geka 60:830–833PubMedGoogle Scholar
  72. Tada T, Fukuda H, Matsui K, Hirashima T, Hosono M, Takada Y, Inoue Y (2005) Non-small-cell lung cancer: reirradiation for loco-regional relapse previously treated with radiation therapy. Int J Clin Oncol 10:247–250PubMedCrossRefGoogle Scholar
  73. Vanuytsel LJ, Vansteenkiste JF, Stroobants SG, De Leyn PR, De Wever W, Verbeken EK, Gatti GG, Huyskens DP, Kutcher GJ (2000) The impact of (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET) lymph node staging on the radiation treatment volumes in patients with non-small cell lung cancer. Radiother Oncol 55:317–324PubMedCrossRefGoogle Scholar
  74. Videtic GM, Rice TW, Murthy S, Suh JH, Saxton JP, Adelstein DJ, Mekhail TM (2008) Utility of positron emission tomography compared with mediastinoscopy for delineating involved lymph nodes in stage III lung cancer: insights for radiotherapy planning from a surgical cohort. Int J Radiat Oncol Biol Phys 72:702–706PubMedCrossRefGoogle Scholar
  75. Voltolini L, Paladini P, Luzzi L, Ghiribelli C, Di Bisceglie M, Gotti G (2000) Iterative surgical resections for local recurrent and second primary bronchogenic carcinoma. Eur J Cardiothorac Surg 18:529–534PubMedCrossRefGoogle Scholar
  76. Watanabe Y, Shimizu J, Oda M, Tatsuzawa Y, Hayashi Y, Iwa T (1992) Second surgical intervention for recurrent and second primary bronchogenic carcinoma. Scand J Thorac Cardiovasc Surg 26:73–78PubMedCrossRefGoogle Scholar
  77. Westeel V, Choma D, Clement F, Woronoff-Lemsi M-C, Pugin J-F, Dubiez A, Depierre A (2000) Relevance of an intensive postoperative follow-up after surgery for non-small cell lung cancer. Ann Thorac Surg 70:1185–1190PubMedCrossRefGoogle Scholar
  78. Wu KL, Jiang G-L, Qian H, Wang L-J, Yang H-J, Fu X-L, Zhao S (2003) Three-dimensional conformal radiotherapy for locoregionally recurrent lung carcinoma after external beam irradiation: a prospective phase I-II clinical trial. Int J Radiat Oncol Biol Phys 57:1345–1350PubMedCrossRefGoogle Scholar
  79. Wu K, Ung YC, Hornby J, Freeman M, Hwang D, Tsao MS, Dahele M, Darling G, Maziak DE, Tirona R, Mah K, Wong CS (2010) PET CT thresholds for radiotherapy target definition in non-small-cell lung cancer: how close are we to the pathologic findings? Int J Radiat Oncol Biol Phys 77:699–706PubMedCrossRefGoogle Scholar
  80. Yano T, Hara N, Ichinose Y, Asoh H, Yokoyama H, Ohta M, Hata K (1994) Local recurrence after complete resection for nonsmall-cell carcinoma of the lung. Significance of local control by radiation treatment. J Thorac Cardiovasc Surg 10:8–12Google Scholar
  81. Zimmermann F, Schratzenstaller U, Schill S, Geinitz H, Astner S, Molls M (2008) Hypofractionated stereotactic radiotherapy in primary or recurrent non-small cell lung cancer (abstract). Radiother Oncol 88(Suppl 2):S282Google Scholar
  82. Zorlu AF, Selek U, Emri S, Gurkayanak M, Akyol FH (2008) Second line palliative endobronchial radiotherapy with HDR Ir 192 in recurrent lung carcinoma. Yonsei Med J 49:620–624PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Branislav Jeremić
    • 1
  • Francesc Casas
    • 2
  • Igor Stojkovski
    • 3
  • Slobodan Milisavljevic
    • 4
  • Zeljko Dobric
    • 1
  1. 1.Institute of Pulmonary DiseasesSremska KamenicaSerbia
  2. 2.Radiation Oncology DepartmentUniversity ClinicBarcelonaSpain
  3. 3.Institute of OncologySkopjeMacedonia
  4. 4.University HospitalKragujevacSerbia

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