PET/CT in Pancreatic Cancer

Part of the Medical Radiology book series (MEDRAD)


Hardware- fused positron emission tomography (PET) and computed tomography (CT) to PET/CT as a single-step procedure improves the diagnostic accuracy in many oncological diseases. PET/CT using the most applied tracer F-18 fluorodeoxyglucose (FDG) helps in the differentiation malignant from benign pancreatic mass lesions. In proven exocrine pancreatic cancer, additional use iodinated, intravenous contrast in PET/CT combines the considerable advantages of both imaging modalities in detecting distant metastases as well as local staging regarding vascular invasion. Since FDG-uptake in tumor is correlated with tumor viability, FDG-PET/CT can be used for therapy response assessment in a neo-adjuvant, curative setting as well in monitoring radio-chemotherapy in a palliative setting. Further, FDG-PET/CT is able to detect local as well as distant recurrence rather reliably. For neuroendocrine pancreatic ancer, newly developed tracers like F18-DOPA and 68Ga-DOTA-NOC may revolutionize the diagnostic work-up by combining diagnostic as well as therapy related informations into a single exam.


Positron Emission Tomography Pancreatic Cancer Chronic Pancreatitis Peritoneal Carcinomatosis Pancreatic Ductal Adenocarcinoma 
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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  1. 1.Department Medical Radiology, Division of Nuclear MedicineUniversity HospitalZurichSwitzerland

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