Lung Perfusion

Part of the Medical Radiology book series (MEDRAD)


Pulmonary perfusion imaging is conventionally performed by lung scintigraphy using technetium-labeled albumin spheres that are temporarily trapped in the pulmonary capillaries and thus visualize pulmonary perfusion. Although per definition lung perfusion is a dynamic process of pulmonary blood flow over time, imaging of the pulmonary capillary bed or blood volume is an accepted surrogate for lung perfusion. By visualizing the contrast agent distribution in the lung parenchyma, spiral dual energy CT angiography (CTA) provides the opportunity to assess pulmonary vessels and pulmonary perfusion within one fast examination. There is already substantial evidence that pulmonary CTA and dual energy CT (DECT) lung perfusion visualization have complimentary roles in the diagnosis of pulmonary embolism. A simultaneous detection of a clot in a pulmonary artery in the pulmonary CTA and of a perfusion defect in DECT lung perfusion in the corresponding lung segment indicate an occlusive PE. Future studies have to investigate if DECT of lung perfusion might also play a role in the assessment of lung diseases such as emphysema, cystic fibrosis or interstitial lung disease. Dedicated scan and contrast material injection protocols for DECT of lung perfusion as well as post-processing techniques are provided in this chapter. Possible pitfalls in data interpretation are discussed.


Interstitial Lung Disease Perfusion Defect Lung Parenchyma Lung Perfusion Pulmonary Perfusion 
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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Clinical Radiology and Nuclear MedicineUniversity Medical Center Mannheim, Medical Faculty Mannheim of the University of HeidelbergMannheimGermany

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