Breast Disorders

Part of the Medical Radiology book series (MEDRAD)


Breast pathology in children and adolescents is rare. Nevertheless, it is useful for medical practitioners involved in the care of this age group to have practical knowledge of physiological breast development, its normal variation, and the different types of breast lesion encountered in clinical practice. This chapter focuses on the imaging of breast development and specific disorders of the breast encountered in the paediatric and adolescent population.


Congenital Adrenal Hyperplasia Precocious Puberty Phyllode Tumour Tanner Stage Nipple Discharge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Follicular stimulating hormone


Luteinizing hormone


Internal mammary artery


Lateral thoracic artery






Computed tomography


Positron emission tomography


Magnetic resonance imaging


Isolated premature thelarche


Cerebrospinal fluid


Short tau inversion recovery


Magnetic resonance angiography


Magnetic resonance venography


Confidence Interval




  1. Binokay F, Soyupak SK, Inal M et al (2003) Primary and metastatic rhabdomyosarcoma in the breast: report of two pediatric cases. Eur J Radiol 48:282–284PubMedCrossRefGoogle Scholar
  2. Bock K, Duda VF, Hadji P et al (2005) Pathologic breast conditions in childhood and adolescence: evaluation by sonographic diagnosis. J Ultrasound Med 24:1347–1354PubMedGoogle Scholar
  3. Boothroyd A, Carty H (1994) Breast masses in childhood and adolescence. A presentation of 17 cases and a review of the literature. Pediatr Radiol 24:81–84PubMedCrossRefGoogle Scholar
  4. Bower R, Bell MJ, Ternberg JL (1976) Management of breast lesions in children and adolescents. J Pediatr Surg 11:337–346PubMedCrossRefGoogle Scholar
  5. Brand IR, Sapherson DA, Brown TS (1993) Breast imaging in women under 35 with symptomatic breast disease. Br J Radiol 66:394–397PubMedCrossRefGoogle Scholar
  6. Bruni V, Dei M, Deligeoroglou E et al (1990) Breast development in adolescent girls. Adolesc Pediatr Gynecol 3:201–205Google Scholar
  7. Cant PJ, Madden MV, Coleman MG et al (1995) Non-operative management of breast masses diagnosed as fibroadenoma. Br J Surg 82:792–794PubMedCrossRefGoogle Scholar
  8. Chateil JF, Arboucalot F, Pérel Y et al (1998) Breast metastases in adolescent girls: US findings. Pediatr Radiol 28:832–835PubMedCrossRefGoogle Scholar
  9. Chung EM, Cube R, Hall GJ et al (2009) From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation. Radiographics 29:907–931PubMedCrossRefGoogle Scholar
  10. Coffin CM (2002) The breast. In: Stocker JT, Dehner LP (eds) Pediatric pathology, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, pp 993–1015Google Scholar
  11. De Silva NK, Brandt ML (2006a) Disorders of the breast in children and adolescents, Part 1: disorders of growth and infections of the breast. J Pediatr Adolesc Gynecol 19(5):345–349PubMedCrossRefGoogle Scholar
  12. De Silva NK, Brandt ML (2006b) Disorders of the breast in children and adolescents, Part 2: breast masses. J Pediatr Adolesc Gynecol 19:415–418PubMedCrossRefGoogle Scholar
  13. Denoel C, Aguirre MF, Bianco G et al (2009) Idiopathic scoliosis and breast asymmetry. J Plast Reconstr Aesthet Surg 62:1303–1308PubMedCrossRefGoogle Scholar
  14. Dubois J, Garel L, Abela A et al (1997) Lymphangiomas in children: percutaneous sclerotherapy with an alcoholic solution of zein. Radiology 204:651–654PubMedGoogle Scholar
  15. Dubois J, Patriquin HB, Garel L et al (1998) Soft-tissue hemangiomas in infants and children: diagnosis using Doppler sonography. Am J Roentgenol 171:247–252Google Scholar
  16. Duflos C, Plu-Bureau G, Thibaud E et al (2004) Breast diseases in adolescents. In: Sultan C (ed) Paediatric and adolescent gynaecology, vol 7. Karger, Basel, pp 183–196CrossRefGoogle Scholar
  17. Dupont WD, Page DL, Parl FF et al (1994) Long-term risk of breast cancer in women with fibroadenoma. N Eng J Med 331:10–15CrossRefGoogle Scholar
  18. Elsheikh A, Keramopoulos A, Lazaris D et al (2000) Breast tumors during adolescence. Eur J Gynaecol Oncol 21:408–410PubMedGoogle Scholar
  19. Fallat ME, Ignacio RC Jr (2008) Breast disorders in children and adolescents. J Pediatr Adolesc Gynecol 21:311–316PubMedCrossRefGoogle Scholar
  20. Farrow JH, Ashikai H (1969) Breast lesions in young girls. Surg Clin North Am 49:261–269PubMedGoogle Scholar
  21. Feig SA (1984) Radiation risk from mammography: is it clinically significant? Am J Roentgenol 143:469–475Google Scholar
  22. Ferguson CM, Powell RW (1989) Breast masses in young women. Arch Surg 124:1338–1341PubMedCrossRefGoogle Scholar
  23. Furnival CM, Irwin JRM, Gray GM (1983) Breast disease in young women. MJA 2:167–169PubMedGoogle Scholar
  24. Garcia CJ, Espinoza A, Dinamarca V et al (2000) Breast US in children and adolescents. Radio Graphics 20:1605–1612PubMedGoogle Scholar
  25. Gold DG, Neglia JP, Dusenbery KE (2003) Second neoplasms after megavoltage radiation for pediatric tumors. Cancer 97:2588–2596PubMedCrossRefGoogle Scholar
  26. Greydanus DE, Parks DS, Farrell EG (1989) Breast disorders in children and adolescents. Pediatr Clin North Am 36:601–638PubMedGoogle Scholar
  27. Greydanus DE, Matytsina L, Gains M (2006) Breast disorders in children and adolescents. Prim Care Clin Office Pract 33:455–502CrossRefGoogle Scholar
  28. Haber HP, Wollmann HA, Ranke MB (1995) Pelvic ultrasonography: early differentiation between isolated premature thelarche and central precocious puberty. Eur J Pediatr 154:182–186PubMedCrossRefGoogle Scholar
  29. Hayes R, Michell M, Nunnerley HB (1991) Acute inflammation of the breast—the role of breast ultrasound in diagnosis and management. Clin Radiol 144:253–256CrossRefGoogle Scholar
  30. Hindle WH, Davis L, Wright D (1999) Clinical value of mammography for symptomatic women 35 years of age and younger. Am J Obstet Gynecol 180:1484–1490PubMedCrossRefGoogle Scholar
  31. Howarth CB, Caces JN, Pratt CB (1980) Breast metastases in children with rhabdomyosarcoma. Cancer 46:2520–2524PubMedCrossRefGoogle Scholar
  32. Huneeus A, Schilling A, Horvath E et al (2003) Retroareolar cysts in the adolescent. J Pediatr Adolesc Gynecol 16:45–49PubMedCrossRefGoogle Scholar
  33. Jackson VP (1990) The role of US in breast imaging. Radiology 1772:305–311Google Scholar
  34. Kajava Y (1915) The proportions of supernumerary nipples in the Finnish population. Duodecim 31:143–170Google Scholar
  35. Kelly VM, Arif K, Ralston S et al (2006) Bloody nipple discharge in an infant and a proposed diagnostic approach. Pediatrics 117:814–816CrossRefGoogle Scholar
  36. Kronemer KA, Rhee K, Siegel MK et al (2001) Gray scale sonography of breast masses in adolescent girls. J Ultrasound Med 20:491–496PubMedGoogle Scholar
  37. Lee BB, Kim DI, Huh S et al (2001) New experiences with absolute ethanol sclerotherapy in the management of a complex form of congenital venous malformation. J Vasc Surg 334:764–772CrossRefGoogle Scholar
  38. Loud KJ, Micheli LJ (2001) Common athletic injuries in adolescent girls. Curr Opin Pediatr 13:317–322PubMedCrossRefGoogle Scholar
  39. Marshall WA, Tanner JM (1969) Variations in the pattern of pubertal changes in girls. Arch Dis Child 44:291–303PubMedCrossRefGoogle Scholar
  40. McKiernan JF, Hull D (1981) Prolactin, maternal oestrogens, and breast development in the newborn. Arch Dis Child 56:770–774PubMedCrossRefGoogle Scholar
  41. Miaux Y, Lemarchand-Venencie F, Cyna-Gorse F et al (1992) MR imaging of breast hemangioma in female infants. Pediatr Radiol 22:463–464PubMedCrossRefGoogle Scholar
  42. O’Donovan JC, Donaldson JS, Morello FP et al (1997) Symptomatic hemangiomas and venous malformations in infants, children, and young adults: treatment with percutaneous injection of sodium tetradecyl sulfate. Am J Roentgenol 1693:723–729Google Scholar
  43. O’Hare PM, Frieden IJ (2000) Virginal breast hypertrophy. Pediatr Dermatol 17:277–281PubMedCrossRefGoogle Scholar
  44. Ogita S, Tsuto T, Tokiwa K, Takahashi T (1987) Intracystic injection of OK-432: a new sclerosing therapy for cystic hygroma in children. Br J Surg 748:690–691CrossRefGoogle Scholar
  45. Osborne MP, Boolbol SK (2009) Breast Anatomy and Development In: Harris JR, Lippman ME, Morrow M et al (eds) Diseases of the breast 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1–12Google Scholar
  46. Pacinda S, Ramzy I (1998) Fine-needle aspiration of breast masses: a review of its role in diagnosis and management in adolescent patients. J Adolesc Health 23:3–6PubMedCrossRefGoogle Scholar
  47. Ramirez G, Ansfield FJ (1968) Carcinoma of the Breast in Children. AMA Arch Surg 96:222–225PubMedCrossRefGoogle Scholar
  48. Ries LA, Eisner MP, Kosary CL, et al (eds) (2005) SEER cancer statistics review, 1975–2002. Bethesda, MD. National Cancer Institute, Accessed 12 Oct 2010
  49. Rogers DA, Lobe TE, Rao BN (1994) Breast malignancy in children. J Pediatr Surg 29:48–51PubMedCrossRefGoogle Scholar
  50. Rohn RD (1984) Galactorrhea in the adolescent. J Adolesc Health Care 5:37–42PubMedCrossRefGoogle Scholar
  51. Rosen PP (1985) Papillary duct hyperplasia of the breast in children and young adults. Cancer 56(7):1611–1617PubMedCrossRefGoogle Scholar
  52. Rudoy RC, Nelson JD (1975) Breast abscess during the neonatal period. Am J Dis Child 129:1031–1034PubMedGoogle Scholar
  53. Sakorafas GH (2001) Nipple discharge: current diagnostic and therapeutic approaches. Cancer Treat Rev 27:275–282PubMedCrossRefGoogle Scholar
  54. Selamzade M, Gidener C, Koyuncuoglu M et al (1999) Borderline phyllodes tumour in an 11-year-old girl. Pediatr Surg Int 15:427–428PubMedCrossRefGoogle Scholar
  55. Shamberger RC (1996) Congenital chest wall deformities. Curr Probl Surg 33:469–542PubMedCrossRefGoogle Scholar
  56. Siegal A, Kaufman Z, Siegal G (1992) Breast masses in adolescent females. J Surg Oncol 51:169–173PubMedCrossRefGoogle Scholar
  57. Siegel MJ (2002) Chest. In: Siegel MJ (ed) Pediatric sonography, 3rd edn. Lippincott Williams & Williams, Philadelphia, pp 201–211Google Scholar
  58. Stanhope R, Traggiai C (2004) Precocious puberty (complete, partial). Endocr Dev 7:57–65PubMedCrossRefGoogle Scholar
  59. Stavros AT, Thickman D, Rapp CL et al (1995) Solid breast nodules: use of sonography to distinguish between benign and malignant lesions. Radiology 196:123–134PubMedGoogle Scholar
  60. Tabár L, Dean PB, Péntek Z (1983) Galactography: the diagnostic procedure of choice for nipple discharge. Radiology 149:31–38PubMedGoogle Scholar
  61. Templeman C, Hertweck SP (2000) Breast disorders in the pediatric and adolescent patient. Obstet Gynecol Clin North Am 27:19–34PubMedCrossRefGoogle Scholar
  62. Vade A, Lafita VS, Ward KA et al (2008) Role of breast sonography in imaging of adolescents with palpable solid breast masses. Am J Roentgenol 191:659–663CrossRefGoogle Scholar
  63. Venta LA, Dudiak CM, Salomon CG (1994) Sonographic evaluation of the breast. Radiographics 14:29–50PubMedGoogle Scholar
  64. Welch ST, Babcock DS, Ballard ET (2004) Sonography of pediatric male breast masses: gynecomastia and beyond. Pediatr Radiol 34:952–957PubMedCrossRefGoogle Scholar
  65. West KW, Rescorla FJ, Scherer LR et al (1995) Diagnosis and treatment of symptomatic breast masses in the pediatric population. J Pediatr Surg 130:182–187CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • Gurdeep S. Mann
    • 1
  • Asha Shivaram
    • 2
  • Andrew Healey
    • 1
  1. 1.Department of Paediatric RadiologyAlder Hey Children’s Hospital NHS Foundation TrustLiverpoolUK
  2. 2.Department of RadiologyRoyal Liverpool and Broadgreen University Hospitals NHS TrustLiverpoolUK

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