Eye Tumors

  • John E. Munzenrider
Part of the Medical Radiology book series (MEDRAD)


The question of re-irradiating the eye after ocular radiation is rarely raised, since the eye is irradiated infrequently as a primary target. Rather, significant efforts are made to minimize the dose received incidentally by the eye during treatment of tumors of the orbit or peri-orbital areas, or of other head and neck or central nervous system sites. CT-based 3D treatment planning is essential for treating these sites, and the eye itself, since availability of archived dosimetry data regarding previously administered irradiation is invaluable when considering re-irradiation of the eye, or of new or recurrent tumors involving the orbit or other adjacent sites. This chapter will discuss the need for radiation oncologists to be aware of the differing threshold doses for complications involving various parts of the eye, specifically the lens, optic nerve, macula, and retina, as well as the tolerance of the lacrimal gland and the tear-producing cells in the eyelids. Recommendations are provided for determining the advisability of attempting re-irradiation of the eye after primary treatment with low, intermediate, or high doses. Advantages of focused radiation therapy techniques, specifically external beam proton therapy and episcleral radionuclide plaque brachytherapy for primary treatment or for re-irradiation of discrete ocular tumors are discussed. Finally, results of two retrospective studies of proton beam re-irradiation of ocular melanomas are described.


Optic Neuritis Macular Degeneration Lacrimal Gland Proton Beam Therapy Ocular Melanoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of Radiation Oncology, Cox 802Massachusetts General HospitalBostonUSA

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