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Advancement in Lung Cancer Diagnosis: A Comprehensive Review of Deep Learning Approaches

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Interdisciplinary Cancer Research

Abstract

Lung cancer continues to pose a significant global health challenge. To overcome this challenge, continuous advancements are being achieved in diagnostic methodologies to enhance early detection and improve patient outcomes. This chapter provides a thorough examination of recent progress in lung cancer diagnosis through an extensive survey of deep learning approaches. Focusing on the integration of artificial intelligence (AI) techniques with medical imaging, the chapter encompasses an analysis of convolutional neural networks (CNNs), recurrent neural networks (RNNs), including long short-term memory (LSTMs) networks, and generative-pretrained transformers (GPTs) or large language models (LLMs). The chapter delves into the evolution of deep learning models for lung cancer detection, emphasizing their performance in image classification, lesion segmentation, and overall diagnostic accuracy. Additionally, we also showcase the literature that explores the integration of diverse imaging modalities, such as computed tomography (CT), positron emission tomography (PET), and magnetic resonance imaging (MRI), within deep learning frameworks to enhance the robustness and reliability of diagnostic systems. Furthermore, the review addresses the challenges inherent in the exploration of deep learning in lung cancer diagnosis, including issues related to data quality, model interpretability, and generalizability. Strategies to address these challenges, such as transfer learning, data augmentation (based on generative adversarial networks), and transformers, are thoroughly discussed. The comprehensive analysis presented in this chapter aims to provide a consolidated understanding of the current landscape of deep learning approaches in lung cancer diagnosis. By highlighting recent advancements, challenges, and potential solutions, this chapter contributes to the ongoing dialogue within the scientific community, fostering the development of more effective and reliable tools for early detection and management of lung cancer.

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References

  • Ardila D, Kiraly AP, Bharadwaj S, Choi B, Reicher JJ, Peng L, Tse D, Etemadi M, Ye W, Corrado G, Naidich DP, Shetty S (2019) End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography. Nat Med 25(6):954–961. https://doi.org/10.1038/s41591-019-0447-x

    Article  Google Scholar 

  • Bandi P, Geessink O, Manson Q, Van Dijk M, Balkenhol M, Hermsen M, Ehteshami Bejnordi B, Lee B, Paeng K, Zhong A, Li Q, Zanjani FG, Zinger S, Fukuta K, Komura D, Ovtcharov V, Cheng S, Zeng S, Thagaard J, Dahl AB (2019) From detection of individual metastases to classification of lymph node status at the patient level: the CAMELYON17 challenge. IEEE Trans Med Imaging 38(2):550–560. https://doi.org/10.1109/tmi.2018.2867350

    Article  Google Scholar 

  • Chen CJ, Ding A, Li Z, Luo C, Wallach HS (2021) Weakly supervised lesion localization and classification in chest x-rays: attributes and categories matter. arXiv preprint arXiv:2103.10826

    Google Scholar 

  • Coudray N, Ocampo PS, Sakellaropoulos T, Narula N, Snuderl M, Fenyö D, Moreira AL, Razavian N, Tsirigos A (2018) Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning. Nat Med 24(10):1559–1567. https://doi.org/10.1038/s41591-018-0177-5

    Article  Google Scholar 

  • Cruz-Roa A, Gilmore H, Basavanhally A et al (2017) Accurate and reproducible invasive breast cancer detection in whole-slide images: a deep learning approach for quantifying tumor extent. Sci Rep 7:46450. https://doi.org/10.1038/srep46450

    Article  Google Scholar 

  • Dosovitskiy A, Brown T, Houlsby N, Kolesnikov A, Beyer L, Zhai X, Kavukcuoglu K (2020) An image is worth 16x16 words: transformers for image recognition at scale. arXiv preprint arXiv:2103.10826

    Google Scholar 

  • Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S (2020) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542(7639):115–118. https://doi.org/10.1038/nature21056

    Article  Google Scholar 

  • Huynh E, Hosny A, Guthier C (2016) A two-stage transfer learning algorithm in medical imaging. Proceedings of the IEEE conference on computer vision and pattern recognition workshops (CVPRW), pp 1–6. https://doi.org/10.1109/CVPRW.2016.16

  • Janowczyk A, Zuo R, Gilmore H (2017) CNN-based segmentation of histology images for prediction of cancer grade. J Pathol Inf 8:27. https://doi.org/10.4103/jpi.jpi_34_17

    Article  Google Scholar 

  • Nam JG, Park S, Hwang EJ, Lee JH, Jin KN, Lim KY, Park HJ (2022) Development and validation of deep learning-based automatic detection algorithm for malignant pulmonary nodules on chest radiographs. Radiology:211108. https://doi.org/10.1148/radiol.2018180237

  • Rajpurkar P, Irvin J, Zhu K, Yang B, Mehta H, Duan T, Ng AY (2017) Chexnet: radiologist-level pneumonia detection on chest x-rays with deep learning. arXiv preprint arXiv:1711.05225

    Google Scholar 

  • Setio AAA, Traverso A, de Bel T, Berens MSN, van den Bogaard C, Cerello P, Chen H, Dou Q, Fantacci ME, Geurts B, van der Gugten R, Heng PA, Jansen B, de Kaste MMJ, Kotov V, Lin JY-H, Manders JTMC, Sóñora-Mengana A, García-Naranjo JC, Papavasileiou E (2017) Validation, comparison, and combination of algorithms for automatic detection of pulmonary nodules in computed tomography images: the LUNA16 challenge. Med Image Anal 42:1–13. https://doi.org/10.1016/j.media.2017.06.015

    Article  Google Scholar 

  • Shin H, Roth HR, Gao M, Lu L, Xu Z, Nogues I, Summers RM (2016) Deep convolutional neural networks for computer-aided detection: CNN architectures, dataset characteristics and transfer learning. IEEE Trans Med Imaging 35(5):1285–1298. https://doi.org/10.1109/TMI.2016.2528162

    Article  Google Scholar 

  • Sirinukunwattana K, Raza SE, Tsang YW, Snead DR, Cree IA, Raj-poot NM (2016) Locality sensitive deep learning for detection and classification of nuclei in routine colon cancer histology images. IEEE Trans Med Imaging 35(5):1196–1206. https://doi.org/10.1109/TMI.2016.2525803

    Article  Google Scholar 

  • Wang X, Kang J, Zhang X (2020) A novel lung nodule detection system for CT images based on region growing and support vector machine. IEEE Access 8:182475–182483. https://doi.org/10.1109/ACCESS.2020.3029034

    Article  Google Scholar 

  • Yang B, Chen J, Liu W, Han Z, Guo Z (2021) A novel deep learning model for the identification and classification of lung nodules using global and local receptive fields. Comput Med Imaging Graph 89:101824

    Google Scholar 

  • Yuan Y, Bar-Yoseph H, Yu S, Jiang H, Dewan M, Lubin N (2019) Deep learning for automated contouring of primary tumor volumes by MRI for nasopharyngeal carcinoma. Radiat Oncol 13(1):1–10. https://doi.org/10.1186/s13014-018-1127-y

    Article  Google Scholar 

  • Zhang W, Xie Y, Li L, Liu S, Zhang L, Tian J (2019) A transfer learning strategy for deep learning-based classification of 18F-FDG-PET images. Med Phys 46(7):3084–3093. https://doi.org/10.1002/mp.13547

    Article  Google Scholar 

  • Zhang L, Lu L, Nogues I, Summers RM, Liu S, Yao J, Li Q (2020) DeepPulmonary: a deep learning-based detection system for pulmonary nodules using chest CTs. IEEE Trans Med Imaging 39(3):1169–1179. https://doi.org/10.1109/TMI.2019.2945131

    Article  Google Scholar 

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Correspondence to Djamel Bouchaffra .

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Bouchaffra, D., Ykhlef, F., Benbelkacem, S. (2024). Advancement in Lung Cancer Diagnosis: A Comprehensive Review of Deep Learning Approaches. In: Interdisciplinary Cancer Research. Springer, Cham. https://doi.org/10.1007/16833_2024_302

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  • DOI: https://doi.org/10.1007/16833_2024_302

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