Abstract
Cancer is a substantially lethal cell disease characterized by uncontrolled cell proliferation and neoplastic progression resulting in dysfunction of the control points of the cell cycle and the programmed cell death mechanisms. In this chapter, the current place of phytochemicals as epigenetic regulators in modern molecular cancer research was reviewed. The current works, which include the possible mechanisms of phytochemicals on non-coding RNAs, DNA methylation, and histone modifications on various cancers, were reviewed. It was determined that different phytochemicals regulate gene expression by up- and down-regulation of miRNAs and lncRNAs. It was also determined that phytochemicals differentiate gene expression levels by changing acetylation and methylation patterns of histone and/or DNA molecules. Nature is a great drugstore that contains minimal side-effect phytochemicals that function with many different genetic and epigenetic mechanisms awaiting discovery. The near future outcomes from molecular biological, pharmaceutical, and pharmacokinetic studies will be the guide for maximum benefit from all these natural components to overcome cancer as epidrugs.
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Goker Bagca, B., Biray Avci, C. (2022). Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation. In: Rezaei, N. (eds) Cancer Research: An Interdisciplinary Approach. Interdisciplinary Cancer Research, vol 1. Springer, Cham. https://doi.org/10.1007/16833_2022_44
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