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The Role of Tumoroids in Cancer Research

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Cancer Research: An Interdisciplinary Approach

Part of the book series: Interdisciplinary Cancer Research ((ICR,volume 1))

Abstract

The optimal tumor model improves cancer diagnosis, prognosis, and therapeutics studies. In tumor modeling, it is crucial to mimic the tumor microenvironment (TME) that includes cellular heterogenicity and tumor cell communications. Traditional 2D cancer cell culture and early 3D culture had many deficiencies in imitating the genotype and phenotype of TME. However, newly developed 3D tumor organoids or tumoroids accurately recapitulate the tumor TME and its cellular components. The present chapter highlights the recent advances in tumoroid cultivation and its application in cancer research. Tumoroids have been used to study different aspects of cancer biology, such as mutational signatures of tumors and cancer-stromal cell interactions in tumorigenesis and cancer progression. They are also employed to generating living biobanks of tumors and performing drug screens and pharmacogenetic studies. Moreover, the contribution of advanced techniques such as genetic manipulation and cutting-edge analysis tools makes the tumoroid model a perfect platform for addressing the gaps in personalized medicine and drug development.

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Authors and Affiliations

  1. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Mahsa Yousefpour Marzbali & Nima Rezaei

  2. International Network of Stem Cell (INSC), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Mahsa Yousefpour Marzbali

  3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  4. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden

    Nima Rezaei

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  1. Mahsa Yousefpour Marzbali
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  1. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden

    Nima Rezaei

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Yousefpour Marzbali, M., Rezaei, N. (2023). The Role of Tumoroids in Cancer Research. In: Rezaei, N. (eds) Cancer Research: An Interdisciplinary Approach. Interdisciplinary Cancer Research, vol 1. Springer, Cham. https://doi.org/10.1007/16833_2022_112

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