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Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications

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Concepts and Principles of Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 260))

Abstract

Ion channels are macromolecular proteins that form water-filled pores in cell membranes and they are critical for a variety of physiological and pharmacological functions. Dysfunctional ion channels can cause diseases known as channelopathies. Ion channels are encoded by approximately 400 genes, representing the second largest class of proven drug targets for therapeutic areas including neuropsychiatric disorders, cardiovascular and metabolic diseases, immunological diseases, nephrological diseases, gastrointestinal diseases, pulmonary/respiratory diseases, and many cancers. With more ion channel structures are being solved and functional robust assays are being developed, there are tremendous opportunities for identifying specific modulators targeting ion channels for new therapy.

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Authors and Affiliations

  1. Department of Pharmacology, Qingdao University School of Pharmacy, Qingdao, China

    Yani Liu & KeWei Wang

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  1. Yani Liu
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  2. KeWei Wang
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Correspondence to KeWei Wang .

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Editors and Affiliations

  1. Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

    James E. Barrett

  2. Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, UK

    Clive P. Page

  3. Department of Pharmacology, Johannes Gutenberg University, Mainz, Rheinland-Pfalz, Germany

    Martin C. Michel

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Liu, Y., Wang, K. (2019). Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications. In: Barrett, J., Page, C., Michel, M. (eds) Concepts and Principles of Pharmacology. Handbook of Experimental Pharmacology, vol 260. Springer, Cham. https://doi.org/10.1007/164_2019_333

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