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Electrophysiological Actions of N/OFQ

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The Nociceptin/Orphanin FQ Peptide Receptor

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 254))

Abstract

Whilst the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) has similar intracellular coupling mechanisms to opioid receptors, it has distinct modulatory effects on physiological functions such as pain. These actions range from agonistic to antagonistic interactions with classical opioids within the spinal cord and brain, respectively. Understanding the electrophysiological actions of N/OFQ has been crucial in ascertaining the mechanisms by which these agonistic and antagonistic interactions occur. These similarities and differences between N/OFQ and opioids are due to the relative location of NOP versus opioid receptors on specific neuronal elements within these CNS regions. These mechanisms result in varied cellular actions including postsynaptic modulation of ion channels and presynaptic regulation of neurotransmitter release.

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Change history

  • 01 June 2019

    In the last paragraph of Sect. 2.1.2 on line 3 the word ‘off-cells’ is misspelt. It should be ‘on-cells’.

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Authors and Affiliations

  1. Pain Management Research Institute, Kolling Institute of Medical Research, Northern Clinical School, Faculty of Medicine and Health, The University of Sydney and Royal North Shore Hospital, St Leonards, NSW, Australia

    Bryony L. Winters & Christopher W. Vaughan

  2. Discipline of Pharmacology, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia

    Macdonald J. Christie

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  1. Bryony L. Winters
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  3. Christopher W. Vaughan
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Correspondence to Bryony L. Winters .

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  1. Department of Physiology and Pharmacology, Wake Forest University, School of Medicine, Winston-Salem, NC, USA

    Mei-Chuan Ko

  2. Department of Medical Sciences, Section of Pharmacology, University of Ferrara, Ferrara, Italy

    Girolamo Caló

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Winters, B.L., Christie, M.J., Vaughan, C.W. (2019). Electrophysiological Actions of N/OFQ. In: Ko, MC., Caló, G. (eds) The Nociceptin/Orphanin FQ Peptide Receptor. Handbook of Experimental Pharmacology, vol 254. Springer, Cham. https://doi.org/10.1007/164_2019_205

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