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Sigma Receptors and Alcohol Use Disorders

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Sigma Proteins: Evolution of the Concept of Sigma Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 244))

Abstract

Although extensive research has focused on understanding the neurobiological mechanisms underlying alcohol addiction, pharmacological treatments for alcohol use disorders are very limited and not always effective. This constraint has encouraged the search for novel pharmacological targets for alcoholism therapy. Sigma receptors were shown to mediate some of the properties of cocaine and amphetamine, which was attributed to the direct binding of psychostimulants to these receptors. More recently, the role of sigma receptors in the rewarding and reinforcing effects of alcohol was also proposed, and it was suggested that their hyperactivity may result in excessive alcohol drinking. This chapter reviews current knowledge on the topic, and suggests that the sigma receptor system may represent a new therapeutic target for the treatment of alcohol use disorders.

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Authors and Affiliations

  1. Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics and Department of Psychiatry, Boston University School of Medicine, Boston, MA, 02118, USA

    Valentina Sabino & Pietro Cottone

  2. Laboratory of Addictive Disorders, Boston University School of Medicine, 72 E Concord St, R-612, Boston, MA, 02118, USA

    Valentina Sabino & Pietro Cottone

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  1. Valentina Sabino
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  2. Pietro Cottone
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Correspondence to Valentina Sabino .

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Editors and Affiliations

  1. Pharmacology & Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Felix J. Kim

  2. Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Gavril W. Pasternak

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Sabino, V., Cottone, P. (2016). Sigma Receptors and Alcohol Use Disorders. In: Kim, F., Pasternak, G. (eds) Sigma Proteins: Evolution of the Concept of Sigma Receptors. Handbook of Experimental Pharmacology, vol 244. Springer, Cham. https://doi.org/10.1007/164_2016_97

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