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Pharmacology of Mitochondria pp 47–69Cite as

The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 240))

Abstract

Bioenergetics has become central to our understanding of pathological mechanisms as well as the development of new therapeutic strategies and as a tool for gauging disease progression in neurodegeneration, diabetes, cancer, and cardiovascular disease. The view is emerging that inner mitochondrial membrane (IMM) cation channels have a profound effect on mitochondrial function and, consequently, on the metabolic state and survival of the whole cell. Since disruption of the sustained integrity of mitochondria is strongly linked to human disease, pharmacological intervention offers a new perspective concerning neurodegenerative and cardiovascular diseases as well as cancer. This review summarizes our current knowledge regarding IMM cation channels and their roles under physiological conditions as well as in cancer, with special emphasis on potassium channels and the mammalian mitochondrial calcium uniporter.

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Acknowledgements

We are grateful to the Italian Association for Cancer Research (AIRC grant IG 11814 to I.S.) and to the Italian Ministry of Education (PRIN project 2010CSJX4F and 2015795S5W to I.S.), for financial support.

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Authors and Affiliations

  1. Department of Biology, University of Padua, Padua, Italy

    Ildikò Szabò & Luigi Leanza

  2. CNR Institute of Neuroscience, Padua, Italy

    Ildikò Szabò

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  1. Ildikò Szabò
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  2. Luigi Leanza
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Correspondence to Ildikò Szabò or Luigi Leanza .

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Editors and Affiliations

  1. Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Harpreet Singh

  2. Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Shey-Shing Sheu

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Szabò, I., Leanza, L. (2016). The Roles of Mitochondrial Cation Channels Under Physiological Conditions and in Cancer. In: Singh, H., Sheu, SS. (eds) Pharmacology of Mitochondria. Handbook of Experimental Pharmacology, vol 240. Springer, Cham. https://doi.org/10.1007/164_2016_92

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