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Guide to the Pharmacology of Mitochondrial Potassium Channels

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Pharmacology of Mitochondria

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 240))

Abstract

This chapter provides a critical overview of the available literature on the pharmacology of mitochondrial potassium channels. In the first part, the reader is introduced to the topic, and eight known protein contributors to the potassium permeability of the inner mitochondrial membrane are presented. The main part of this chapter describes the basic characteristics of each channel type mentioned in the introduction. However, the most important and valuable information included in this chapter concerns the pharmacology of mitochondrial potassium channels. Several available channel modulators are critically evaluated and rated by suitability for research use. The last figure of this chapter shows the results of this evaluation at a glance. Thus, this chapter can be very useful for beginners in this field. It is intended to be a time- and resource-saving guide for those searching for proper modulators of mitochondrial potassium channels.

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Acknowledgements

This work was supported by the Nencki Institute and partially by a grant from the National Centre of Research and Development, Poland No. MERIS PBS1/B8/1/2012 and by a grant from the Polish National Science Center No. 2015/17/B/NZ1/02496.

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Authors and Affiliations

  1. Laboratory of Intracellular Ion Channels, Department of Biochemistry, Nencki Institute of Experimental Biology, 3 Pasteur Street, 02-093, Warsaw, Poland

    Bartłomiej Augustynek & Adam Szewczyk

  2. Department of Epileptology, University of Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Germany

    Wolfram S. Kunz

Authors
  1. Bartłomiej Augustynek
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  2. Wolfram S. Kunz
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  3. Adam Szewczyk
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Correspondence to Adam Szewczyk .

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Editors and Affiliations

  1. Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Harpreet Singh

  2. Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Shey-Shing Sheu

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Augustynek, B., Kunz, W.S., Szewczyk, A. (2016). Guide to the Pharmacology of Mitochondrial Potassium Channels. In: Singh, H., Sheu, SS. (eds) Pharmacology of Mitochondria. Handbook of Experimental Pharmacology, vol 240. Springer, Cham. https://doi.org/10.1007/164_2016_79

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