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Signalling Pathways Controlling Cellular Actin Organization

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The Actin Cytoskeleton

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 235))

Abstract

The actin cytoskeleton is essential for morphogenesis and virtually all types of cell shape changes. Reorganization is per definition driven by continuous disassembly and re-assembly of actin filaments, controlled by major, ubiquitously operating machines. These are specifically employed by the cell to tune its activities in accordance with respective environmental conditions or to satisfy specific needs.

Here we sketch some fundamental signalling pathways established to contribute to the reorganization of specific actin structures at the plasma membrane. Rho-family GTPases are at the core of these pathways, and dissection of their precise contributions to actin reorganization in different cell types and tissues will thus continue to improve our understanding of these important signalling nodes. Furthermore, we will draw your attention to the emerging theme of actin reorganization on intracellular membranes, its functional relation to Rho-GTPase signalling, and its relevance for the exciting phenomenon autophagy.

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Authors and Affiliations

  1. Department of Cell Biology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124, Braunschweig, Germany

    Anika Steffen, Theresia E. B. Stradal & Klemens Rottner

  2. Zoological Institute, Technische Universität Braunschweig, Spielmannstrasse 7, 38106, Braunschweig, Germany

    Klemens Rottner

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  1. Anika Steffen
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  2. Theresia E. B. Stradal
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  3. Klemens Rottner
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Correspondence to Theresia E. B. Stradal .

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  1. Cell Biology, Life Sciences, BRICS, TU Braunschweig, Braunschweig, Germany

    Brigitte M. Jockusch

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Steffen, A., Stradal, T.E.B., Rottner, K. (2016). Signalling Pathways Controlling Cellular Actin Organization. In: Jockusch, B. (eds) The Actin Cytoskeleton. Handbook of Experimental Pharmacology, vol 235. Springer, Cham. https://doi.org/10.1007/164_2016_35

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