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Changes in Histidine Decarboxylase, Histamine N-Methyltransferase and Histamine Receptors in Neuropsychiatric Disorders

Part of the Handbook of Experimental Pharmacology book series (HEP,volume 241)

Abstract

Compared to other monoamine neurotransmitters, information on the association between the histaminergic system and neuropsychiatric disorders is scarce, resulting in a lack of histamine-related treatment for these disorders. The current chapter tries to combine information obtained from genetic studies, neuroimaging, post-mortem human brain studies and cerebrospinal fluid measurements with data from recent clinical trials on histamine receptor agonists and antagonists, with a view to determining the possible role of the histaminergic system in neuropsychiatric disorders and to pave the way for novel histamine-related therapeutic strategies.

Keywords

  • Histamine
  • Histidine decarboxylase
  • Histamine receptors
  • Histamine N-methyltransferase
  • Neurodegenerative diseases
  • Mood disorders
  • Intellectual disability

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  • DOI: 10.1007/164_2016_125
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Fig. 1
Fig. 2

Abbreviations

AD:

Alzheimer’s disease

CSF:

Cerebrospinal fluid

H1–4R:

Histamine 1–4 receptors

HDC:

l-Histidine decarboxylase

HMT:

Histamine N-methyltransferase

mRNA:

Messenger RNA

PD:

Parkinson’s disease

t-MeHA:

Tele-Methylhistamine

TMN:

Tuberomamillary nucleus

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Acknowledgements

Original research supported by the China Scholarship Council for State Scholarship Fund [grant number (2007) 3020] to Dr. Ling Shan and the China programme of introducing talents of discipline to universities (B13026) to Prof Ai-min Bao and Prof Dick F. Swaab. The work has been awarded a Young Investigators Award by the European histamine research society to Dr. Ling Shan who currently supported by a 2014 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation. The authors are also grateful to the Netherlands Brain Bank (Director Dr. Inge Huitinga) for providing human brain material and clinical details, and to Mrs. W.T.P. Verweij for secretarial assistance.

Conflicts of Interest: We declare that we have no conflicts of interest.

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Shan, L., Bao, AM., Swaab, D.F. (2017). Changes in Histidine Decarboxylase, Histamine N-Methyltransferase and Histamine Receptors in Neuropsychiatric Disorders. In: Hattori, Y., Seifert, R. (eds) Histamine and Histamine Receptors in Health and Disease. Handbook of Experimental Pharmacology, vol 241. Springer, Cham. https://doi.org/10.1007/164_2016_125

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