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Bacteriophage-Mediated Biocontrol of Wound Infections, and Ecological Exploitation of Biofilms by Phages

  • Stephen T. AbedonEmail author
Chapter
Part of the Recent Clinical Techniques, Results, and Research in Wounds book series (RCTRRW, volume 1)

Abstract

Considered in this chapter is the use of bacterial viruses, a.k.a., bacteriophages or phages, to control or eliminate unwanted bacteria, e.g., as may be found in association with wounds. Infected wounds often have a biofilm component, and as a consequence this chapter focuses in part on interactions between bacteriophages and biofilms. A growing literature exists exploring in vitro models of the treatment of biofilms using phages, and though not emphasized here a listing of relevant studies is provided. I then present an overview of the phage wound-treatment, animal-model literature. I follow this with emphasis on the clinical treatment of wound infections using phages. Lastly, as phage-biofilm interactions are inherently ecological, I explore their ecology, concluding with consideration of how ecological appreciation might help to improve anti-biofilm effectiveness.

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of MicrobiologyThe Ohio State UniversityMansfieldUSA

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