Skip to main content

Wound Dressings and Comparative Effectiveness Data

  • Chapter
  • First Online:
Book cover Chronic Wounds, Wound Dressings and Wound Healing

Abstract

Wounds are among the most ubiquitous of medical problems, occurring in the young and old and the healthy and ill. Wounds may be of traumatic, medical, or surgical origin, and they may be acute or chronic. Wound healing is an intricately complex process, and countless cells, cytokines, and secreted factors must work in a coordinated fashion for proper healing to occur. Both intrinsic and extrinsic factors may impair wound healing, resulting in the transition of an acute to chronic wound. Numerous wound-healing products are available in the market to manage the extensive scope of cutaneous wounds. This chapter aims to review the breath of wound dressings and relevant clinical data, allowing the clinician to make an informed decision in regard to the optimal dressing for a wound.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Flint PW, Haughey BH, Robbins KT, Thomas JR, Niparko JK, Lund VJ, Lesperance MM (2014) Cummings otolaryngology-head and neck surgery. Elsevier Health Sciences, Philadelphia

    Google Scholar 

  2. Goebeler M, Yoshimura T, Toksoy A, Ritter U, Brocker EB, Gillitzer R (1997) The chemokine repertoire of human dermal microvascular endothelial cells and its regulation by inflammatory cytokines. J Invest Dermatol 108(4):445–451

    CAS  PubMed  Google Scholar 

  3. Broughton G 2nd, Janis JE, Attinger CE (2006) The basic science of wound healing. Plast Reconstr Surg 117(7 Suppl):12S–34S

    CAS  PubMed  Google Scholar 

  4. Clark RA, Lanigan JM, DellaPelle P, Manseau E, Dvorak HF, Colvin RB (1982) Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization. J Invest Dermatol 79(5):264–269

    CAS  PubMed  Google Scholar 

  5. Donaldson DJ, Mahan JT (1988) Keratinocyte migration and the extracellular matrix. J Invest Dermatol 90(5):623–628

    CAS  PubMed  Google Scholar 

  6. Zhang J, Cao R, Zhang Y, Jia T, Cao Y, Wahlberg E (2009) Differential roles of PDGFR-alpha and PDGFR-beta in angiogenesis and vessel stability. FASEB J 23(1):153–163

    CAS  PubMed  Google Scholar 

  7. Singer AJ, Clark RA (1999) Cutaneous wound healing. N Engl J Med 341(10):738–746

    CAS  PubMed  Google Scholar 

  8. Monaco JL, Lawrence WT (2003) Acute wound healing an overview. Clin Plast Surg 30(1):1–12

    PubMed  Google Scholar 

  9. Kirsner RS, Eaglstein WH (1993) The wound healing process. Dermatol Clin 11(4):629–640

    CAS  PubMed  Google Scholar 

  10. Honrado CP, Murakami CS (2005) Wound healing and physiology of skin flaps. Facial Plast Surg Clin North Am 13(2):203–214

    PubMed  Google Scholar 

  11. Lee DY, Cho KH (2005) The effects of epidermal keratinocytes and dermal fibroblasts on the formation of cutaneous basement membrane in three-dimensional culture systems. Arch Dermatol Res 296(7):296–302

    PubMed  Google Scholar 

  12. Dvorak HF, Brown LF, Detmar M, Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146(5):1029–1039

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Darby I, Skalli O, Gabbiani G (1990) Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab Investig 63(1):21–29

    CAS  PubMed  Google Scholar 

  14. Gantwerker EA, Hom DB (2011) Skin: histology and physiology of wound healing. Facial Plast Surg Clin North Am 19(3):441–453

    PubMed  Google Scholar 

  15. Percival SL, Hill KE, Williams DW, Hooper SJ, Thomas DW, Costerton JW (2012) A review of the scientific evidence for biofilms in wounds. Wound Repair Regen 20(5):647–657

    PubMed  Google Scholar 

  16. Winter GD (1962) Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 193:293–294

    CAS  PubMed  Google Scholar 

  17. Forrest RD (1982) Early history of wound treatment. J R Soc Med 75(3):198–205

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Okan D, Woo K, Ayello EA, Sibbald G (2007) The role of moisture balance in wound healing. Adv Skin Wound Care 20(1):39–53

    PubMed  Google Scholar 

  19. Attinger CE, Janis JE, Steinberg J, Schwartz J, Al-Attar A, Couch K (2006) Clinical approach to wounds: debridement and wound bed preparation including the use of dressings and wound-healing adjuvants. Plast Reconstr Surg 117(7 Suppl):72S–109S

    CAS  PubMed  Google Scholar 

  20. Ayello EA, Cuddigan JE (2004) Debridement: controlling the necrotic/cellular burden. Adv Skin Wound Care 17(2):66–75

    PubMed  Google Scholar 

  21. Broughton G 2nd, Janis JE, Attinger CE (2006) A brief history of wound care. Plast Reconstr Surg 117(7 Suppl):6S–11S

    CAS  PubMed  Google Scholar 

  22. McCallon SK, Knight CA, Valiulus JP, Cunningham MW, McCulloch JM, Farinas LP (2000) Vacuum-assisted closure versus saline-moistened gauze in the healing of postoperative diabetic foot wounds. Ostomy Wound Manage 46(8):28–32, 4

    CAS  PubMed  Google Scholar 

  23. Bolton LL, Monte K, Pirone LA (2000) Moisture and healing: beyond the jargon. Ostomy Wound Manage 46(1A Suppl):51S–62S

    CAS  PubMed  Google Scholar 

  24. Ovington LG (2001) Hanging wet-to-dry dressings out to dry. Home Healthc Nurse 19(8):477–483

    CAS  PubMed  Google Scholar 

  25. Lawrence JC (1994) Dressings and wound infection. Am J Surg 167(1A):21S–24S

    CAS  PubMed  Google Scholar 

  26. Hutchinson JJ, Lawrence JC (1991) Wound infection under occlusive dressings. J Hosp Infect 17(2):83–94

    CAS  PubMed  Google Scholar 

  27. Hutchinson J (1993) A prospective clinical trial of wound dressings to investigate the rate of infection under occlusion. In Proceedings of the European Conference on advances in Wound Management, London, England, pp 93–96

    Google Scholar 

  28. Vermeulen H, Ubbink D, Goossens A, de Vos R, Legemate D (2004) Dressings and topical agents for surgical wounds healing by secondary intention. Cochrane Database Syst Rev 2:CD003554

    Google Scholar 

  29. Ubbink DT, Vermeulen H, van Hattem J (2008) Comparison of homecare costs of local wound care in surgical patients randomized between occlusive and gauze dressings. J Clin Nurs 17(5):593–601

    PubMed  Google Scholar 

  30. Ubbink DT, Vermeulen H, Goossens A, Kelner RB, Schreuder SM, Lubbers MJ (2008) Occlusive vs gauze dressings for local wound care in surgical patients: a randomized clinical trial. Arch Surg 143(10):950–955

    PubMed  Google Scholar 

  31. Persson K, Salemark L (2000) How to dress donor sites of split thickness skin grafts: a prospective, randomised study of four dressings. Scand J Plast Reconstr Surg Hand Surg 34(1):55–59

    CAS  PubMed  Google Scholar 

  32. Dinner MI, Peters CR, Sherer J (1979) Use of a semipermeable polyurethane membrane as a dressing for split-skin graft donor sites. Plast Reconstr Surg 64(1):112–114

    CAS  PubMed  Google Scholar 

  33. Barnett A, Berkowitz RL, Mills R, Vistnes LM (1983) Scalp as skin graft donor site: rapid reuse with synthetic adhesive moisture vapor permeable dressings. J Trauma 23(2):148–151

    CAS  PubMed  Google Scholar 

  34. Rubio PA (1991) Use of semiocclusive, transparent film dressings for surgical wound protection: experience in 3637 cases. Int Surg 76(4):253–254

    CAS  PubMed  Google Scholar 

  35. Seaman S (2002) Dressing selection in chronic wound management. J Am Podiatr Med Assoc 92(1):24–33

    PubMed  Google Scholar 

  36. Andersen KE, CPM F, Gad P, Larsen AM, Larsen JR, van Neer PAFA, Vuerstaek J, Wuite J, HAM N (2002) A randomized, controlled study to compare the effectiveness of two foam dressings in the management of lower leg ulcers. Ostomy Wound Manage 48(8):34–41

    Google Scholar 

  37. Choucair M, Phillips T (1999) Wound dressings. In: Freedberg IM, Fitzpatrick TB (eds) Fitzpatrick’s dermatology in general medicine, 5th edn. McGraw-Hill, New York, pp 2954–2958

    Google Scholar 

  38. Ovington L (1998) The well-dressed wound: an overview of dressing types. Wounds 10(Suppl A):1A–11A

    Google Scholar 

  39. Darkovich SL, Brown-Etris M, Spencer M (1990) Biofilm hydrogel dressing: a clinical evaluation in the treatment of pressure sores. Ostomy Wound Manage 29:47–60

    CAS  PubMed  Google Scholar 

  40. Kaya AZ, Turani N, Akyuz M (2005) The effectiveness of a hydrogel dressing compared with standard management of pressure ulcers. J Wound Care 14(1):42–44

    CAS  PubMed  Google Scholar 

  41. Varghese MC, Balin AK, Carter DM, Caldwell D (1986) Local environment of chronic wounds under synthetic dressings. Arch Dermatol 122(1):52–57

    CAS  PubMed  Google Scholar 

  42. Mulder G, Jones R, Cederholm-Williams S, Cherry G, Ryan T (1993) Fibrin cuff lysis in chronic venous ulcers treated with a hydrocolloid dressing. Int J Dermatol 32(4):304–306

    CAS  PubMed  Google Scholar 

  43. Chvapil M, Holubec H, Chvapil T (1991) Inert wound dressing is not desirable. J Surg Res 51(3):245–252

    CAS  PubMed  Google Scholar 

  44. Gokoo C, Burhop K (1993) A comparative study of wound dressings on full-thickness wounds in micropigs. Decubitus 6(5):42–3, 6, 8

    CAS  PubMed  Google Scholar 

  45. Agren MS, Mertz PM, Franzen L (1997) A comparative study of three occlusive dressings in the treatment of full-thickness wounds in pigs. J Am Acad Dermatol 36(1):53–58

    CAS  PubMed  Google Scholar 

  46. Qin Y, Gilding DK (1996) Alginate fibres and wound dressings. Med Device Technol 7(9):32–41

    CAS  PubMed  Google Scholar 

  47. Thomas S, Tucker C (1989) Sorbsan in the management of leg ulcers. Pharm J 243:706–709

    Google Scholar 

  48. Smith J, Lewis J (1990) Sorbsan and leg ulcers. Pharm J 244:468

    Google Scholar 

  49. Franks P (1990) Sorbsan and leg ulcers. Pharm J 244:468

    Google Scholar 

  50. Attwood A (1989) Calcium alginate dressing accelerates split skin graft donor site healing. Br J Plast Surg 42(4):373–379

    CAS  PubMed  Google Scholar 

  51. Cannavo M, Fairbrother G, Owen D, Ingle J, Lumley T (1998) A comparison of dressings in the management of surgical abdominal wounds. J Wound Care 7(2):57–62

    CAS  PubMed  Google Scholar 

  52. Moody M (1991) Calcium alginate: a dressing trial. Nurs Stand 5(51):3–6

    CAS  PubMed  Google Scholar 

  53. Pirone LA, Bolton LL, Monte KA, Shannon RJ (1992) Effect of calcium alginate dressings on partial-thickness wounds in swine. J Investig Surg 5(2):149–153

    CAS  Google Scholar 

  54. Thomas S (2010) Surgical dressings and wound management. Medetec Publications, Cardiff, South Wales

    Google Scholar 

  55. Robinson BJ (2000) The use of a hydrofibre dressing in wound management. J Wound Care 9(1):32–34

    CAS  PubMed  Google Scholar 

  56. Barnea Y, Amir A, Leshem D, Zaretski A, Weiss J, Shafir R, Gur E (2004) Clinical comparative study of aquacel and paraffin gauze dressing for split-skin donor site treatment. Ann Plast Surg 53(2):132–136

    PubMed  Google Scholar 

  57. Vloemans AF, Soesman AM, Kreis RW, Middelkoop E (2001) A newly developed hydrofibre dressing, in the treatment of partial-thickness burns. Burns 27(2):167–173

    CAS  PubMed  Google Scholar 

  58. Guest JF, Ruiz FJ (2005) Modelling the cost implications of using carboxymethylcellulose dressing compared with gauze in the management of surgical wounds healing by secondary intention in the US and UK. Curr Med Res Opin 21(2):281–290

    PubMed  Google Scholar 

  59. Ortiz RT, Moffatt LT, Robson MC, Jordan MH, Shupp JW (2012) In vivo and in vitro evaluation of the properties of Drawtex Levafiber wound dressing in an infected burn wound model. Ostomy Wound Manage 21:3

    Google Scholar 

  60. Ochs D, Georgina Uberti M, Donate GA, Abercrombie M, Mannari RJ, Payne WG (2012) Evaluation of mechanisms of action of a hydroconductive wound dressing (Drawtex) in chronic wounds. Ostomy Wound Manage 21:6

    Google Scholar 

  61. Wolcott RD (2012) The effect of a hydroconductive dressing on the suppression of wound biofilm. Wounds 24(5):132–137

    PubMed  Google Scholar 

  62. Spangler D, Rothenburger S, Nguyen K, Jampani H, Weiss S, Bhende S (2003) In vitro antimicrobial activity of oxidized regenerated cellulose against antibiotic-resistant microorganisms. Surg Infect 4(3):255–262. https://doi.org/10.1089/109629603322419599

    Article  Google Scholar 

  63. Hofman D, Wilson J, Poore S, Cherry G, Ryan T (2000) Can traumacel be used in the treatment of chronic wounds? J Wound Care 9(8):393–396

    CAS  PubMed  Google Scholar 

  64. Hughes MA, Yang Y, Cherry GW (2002) Effect of Traumacel P on the growth of human dermal fibroblasts in vitro. J Wound Care 11(4):149–154

    CAS  PubMed  Google Scholar 

  65. Jeschke MG, Sandmann G, Schubert T, Klein D (2005) Effect of oxidized regenerated cellulose/collagen matrix on dermal and epidermal healing and growth factors in an acute wound. Wound Repair Regen 13(3):324–331

    PubMed  Google Scholar 

  66. Perkins K, Davey RB, Wallis KA (1983) Silicone gel: a new treatment for burn scars and contractures. Burns Incl Therm Inj 9(3):201–204

    CAS  PubMed  Google Scholar 

  67. Li-Tsang CW, Lau JC, Choi J, Chan CC, Jianan L (2006) A prospective randomized clinical trial to investigate the effect of silicone gel sheeting (Cica-care) on post-traumatic hypertrophic scar among the Chinese population. Burns 32(6):678–683

    PubMed  Google Scholar 

  68. de Oliveira GV, Nunes TA, Magna LA, Cintra ML, Kitten GT, Zarpellon S, Raposo Do Amaral CM (2001) Silicone versus nonsilicone gel dressings: a controlled trial. Dermatol Surg 27(8):721–726

    PubMed  Google Scholar 

  69. Zurada JM, Kriegel D, Davis IC (2006) Topical treatments for hypertrophic scars. J Am Acad Dermatol 55(6):1024–1031

    PubMed  Google Scholar 

  70. Poston J (2000) The use of silicone gel sheeting in the management of hypertrophic and keloid scars. J Wound Care 9(1):10–16

    CAS  PubMed  Google Scholar 

  71. Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG, Stella M, Teot L, Wood FM, Ziegler UE, International Advisory Panel on Scar M (2002) International clinical recommendations on scar management. Plast Reconstr Surg 110(2):560–571

    PubMed  Google Scholar 

  72. O'Brien L, Pandit A (2006) Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev 1:CD003826

    Google Scholar 

  73. Mofikoya BO, Adeyemo WL, Abdus-Salam AA (2007) Keloid and hypertrophic scars: a review of recent developments in pathogenesis and management. Nig Q J Hosp Med 17(4):134–139

    PubMed  Google Scholar 

  74. Durani P, Bayat A (2008) Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg 61(1):4–17

    CAS  PubMed  Google Scholar 

  75. Warriner R, Burrell R (2005) Infection and the chronic wound: a focus on silver. Adv Skin Wound Care 18(Suppl 1):2–12

    PubMed  Google Scholar 

  76. Burrell RE (2003) A scientific perspective on the use of topical silver preparations. Ostomy Wound Manage 49(5A Suppl):19–24

    PubMed  Google Scholar 

  77. Vermeulen H, van Hattem JM, Storm-Versloot MN, Ubbink DT (2007) Topical silver for treating infected wounds. Cochrane Database Syst Rev 1:CD005486

    Google Scholar 

  78. Jorgensen B, Price P, Andersen KE, Gottrup F, Bech-Thomsen N, Scanlon E, Kirsner R, Rheinen H, Roed-Petersen J, Romanelli M, Jemec G, Leaper DJ, Neumann MH, Veraart J, Coerper S, Agerslev RH, Bendz SH, Larsen JR, Sibbald RG (2005) The silver-releasing foam dressing, Contreet foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial. Int Wound J 2(1):64–73

    PubMed  Google Scholar 

  79. Meaume S, Vallet D, Morere MN, Teot L (2005) Evaluation of a silver-releasing hydroalginate dressing in chronic wounds with signs of local infection. J Wound Care 14(9):411–419

    CAS  PubMed  Google Scholar 

  80. Munter KC, Beele H, Russell L, Crespi A, Grochenig E, Basse P, Alikadic N, Fraulin F, Dahl C, Jemma AP (2006) Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study. J Wound Care 15(5):199–206

    CAS  PubMed  Google Scholar 

  81. Ovington LG (2004) The truth about silver. Ostomy Wound Manage 50(9A Suppl):1S–10S

    PubMed  Google Scholar 

  82. Tomaselli N (2006) The role of topical silver preparations in wound healing. J Wound Ostomy Continence Nurs 33(4):367–378

    PubMed  Google Scholar 

  83. Dissemond J, Gerber V, Kramer A, Riepe G, Strohal R, Vasel-Biergans A, Eberlein T (2010) A practice-oriented recommendation for treatment of critically colonised and locally infected wounds using polihexanide. J Tissue Viability 19(3):106–115

    CAS  PubMed  Google Scholar 

  84. Eberlein T, Haemmerle G, Signer M, Gruber Moesenbacher U, Traber J, Mittlboeck M, Abel M, Strohal R (2012) Comparison of PHMB-containing dressing and silver dressings in patients with critically colonised or locally infected wounds. J Wound Care 21(1):12, 4–6, 8-20

    Google Scholar 

  85. Blair SE, Cokcetin NN, Harry EJ, Carter DA (2009) The unusual antibacterial activity of medical-grade leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis. Eur J Clin Microbiol Infect Dis 28(10):1199–1208

    CAS  PubMed  Google Scholar 

  86. Majtan J, Klaudiny J, Bohova J, Kohutova L, Dzurova M, Sediva M, Bartosova M, Majtan V (2012) Methylglyoxal-induced modifications of significant honeybee proteinous components in manuka honey: possible therapeutic implications. Fitoterapia 83(4):671–677

    CAS  PubMed  Google Scholar 

  87. Gethin G, Cowman S (2009) Manuka honey vs. hydrogel--a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J Clin Nurs 18(3):466–474

    PubMed  Google Scholar 

  88. Gupta SS, Singh O, Bhagel PS, Moses S, Shukla S, Mathur RK (2011) Honey dressing versus silver sulfadiazine dressing for wound healing in burn patients: a retrospective study. J Cutan Aesthet Surg 4(3):183–187

    PubMed  PubMed Central  Google Scholar 

  89. Jull AB, Rodgers A, Walker N (2008) Honey as a topical treatment for wounds. Cochrane Database Syst Rev 4:CD005083

    Google Scholar 

  90. Vallin E (1882) Traite des desinfectants et de la desinfectantion. Masson, Paris

    Google Scholar 

  91. Burks RI (1998) Povidone-iodine solution in wound treatment. Phys Ther 78(2):212–218

    CAS  PubMed  Google Scholar 

  92. Drosou A, Falabella A, Kirsner RS (2003) Antiseptics on wounds: an area of controversy. Wounds 15(5):149–166

    Google Scholar 

  93. Chang S (1971) Modern concept of disinfection. J Sanit Eng Div 5:689–693

    Google Scholar 

  94. Durani P, Leaper D (2008) Povidone-iodine: use in hand disinfection, skin preparation and antiseptic irrigation. Int Wound J 5(3):376–387

    PubMed  Google Scholar 

  95. Phillips P, Wolcott R, Fletcher J, Schultz G (2010) Biofilms made easy. Wound Int 1(3):1–6

    Google Scholar 

  96. Thorn RM, Austin AJ, Greenman J, Wilkins JP, Davis PJ (2009) In vitro comparison of antimicrobial activity of iodine and silver dressings against biofilms. J Wound Care 18(8):343–346

    CAS  PubMed  Google Scholar 

  97. Schultz G, Phillips P, Yang Q, Sampson E (2009) Microbicidal effects of wound dressings on mature bacterial biofilm on porcine skin explants. Poster presented at European Wound Management Association, Helsinki, Finland

    Google Scholar 

  98. Parry AD, Chadwick PR, Simon D, Oppenheim B, McCollum CN (1995) Leg ulcer odour detection identifies beta-haemolytic streptococcal infection. J Wound Care 4(9):404–406

    CAS  PubMed  Google Scholar 

  99. Newman V, Allwood M, Oakes R (1989) The use of metronidazole gel to control the smell of malodorous lesions. Palliat Med 3(4):303–305

    Google Scholar 

  100. Ogura T, Urade M, Matsuya T (1992) Prevention of malodor from intraoral gauze tamponade with the topical use of clindamycin. Oral Surg Oral Med Oral Pathol 74(1):58–62

    CAS  PubMed  Google Scholar 

  101. Chiwenga S, Dowlen H, Mannion S (2009) Audit of the use of sugar dressings for the control of wound odour at Lilongwe Central Hospital, Malawi. Trop Doct 39(1):20–22

    CAS  PubMed  Google Scholar 

  102. Vikatmaa P, Juutilainen V, Kuukasjarvi P, Malmivaara A (2008) Negative pressure wound therapy: a systematic review on effectiveness and safety. Eur J Vasc Endovasc Surg 36(4):438–448

    CAS  PubMed  Google Scholar 

  103. Philbeck TE Jr, Whittington KT, Millsap MH, Briones RB, Wight DG, Schroeder WJ (1999) The clinical and cost effectiveness of externally applied negative pressure wound therapy in the treatment of wounds in home healthcare Medicare patients. Ostomy Wound Manage 45(11):41–50

    PubMed  Google Scholar 

  104. Kaplan M, Daly D, Stemkowski S (2009) Early intervention of negative pressure wound therapy using vacuum-assisted closure in trauma patients: impact on hospital length of stay and cost. Adv Skin Wound Care 22(3):128–132

    PubMed  Google Scholar 

  105. Expert Working Group (2008) Vacuum assisted closure recommendations for use. A consensus document. Int Wound J 5(Suppl. 4):3–19

    Google Scholar 

  106. Koob TJ, Lim JJ, Massee M, Zabek N, Denoziere G (2014) Properties of dehydrated human amnion/chorion composite grafts: implications for wound repair and soft tissue regeneration. J Biomed Mater Res B Appl Biomater 102(6):1353–1362

    PubMed  Google Scholar 

  107. Koob TJ, Rennert R, Zabek N, Massee M, Lim JJ, Temenoff JS, Li WW, Gurtner G (2013) Biological properties of dehydrated human amnion/chorion composite graft: implications for chronic wound healing. Int Wound J 10(5):493–500

    PubMed  PubMed Central  Google Scholar 

  108. Zelen CM, Serena TE, Denoziere G, Fetterolf DE (2013) A prospective randomised comparative parallel study of amniotic membrane wound graft in the management of diabetic foot ulcers. Int Wound J 10(5):502–507

    PubMed  PubMed Central  Google Scholar 

  109. Serena TE, Carter MJ, Le LT, Sabo MJ, DiMarco DT, EpiFix VLUSG (2014) A multicenter, randomized, controlled clinical trial evaluating the use of dehydrated human amnion/chorion membrane allografts and multilayer compression therapy vs. multilayer compression therapy alone in the treatment of venous leg ulcers. Wound Repair Regen 22(6):688–693

    PubMed  Google Scholar 

  110. Zaulyanov L, Kirsner RS (2007) A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers. Clin Interv Aging 2(1):93–98

    PubMed  PubMed Central  Google Scholar 

  111. Zelen CM, Gould L, Serena TE, Carter MJ, Keller J, Li WW (2015) A prospective, randomised, controlled, multi-centre comparative effectiveness study of healing using dehydrated human amnion/chorion membrane allograft, bioengineered skin substitute or standard of care for treatment of chronic lower extremity diabetic ulcers. Int Wound J 12(6):724–732

    PubMed  Google Scholar 

  112. Kakabadze Z, Mardaleishvili K, Loladze G, Javakhishvili I, Chakhunasvili K, Karalashvili L, Sukhitashvili N, Chutkerashvili G, Kakabadze A, Chakhunasvili D (2016) Clinical application of decellularized and lyophilized human amnion/chorion membrane grafts for closing post-laryngectomy pharyngocutaneous fistulas. J Surg Oncol 113(5):538–543

    PubMed  PubMed Central  Google Scholar 

  113. Barski D, Gerullis H, Ecke T, Varga G, Boros M, Pintelon I, Timmermans JP, Winter A, Bagner JW, Otto T (2015) Repair of a vesico-vaginal fistula with amniotic membrane - step 1 of the IDEAL recommendations of surgical innovation. Cent European J Urol 68(4):459–461

    CAS  PubMed  PubMed Central  Google Scholar 

  114. Mohammadi AA, Johari HG, Eskandari S (2013) Effect of amniotic membrane on graft take in extremity burns. Burns 39(6):1137–1141

    PubMed  Google Scholar 

  115. Gottrup F, Apelqvist J, Price P, European Wound Management Association Patient Outcome G (2010) Outcomes in controlled and comparative studies on non-healing wounds: recommendations to improve the quality of evidence in wound management. J Wound Care 19(6):237–268

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aditya Sood M.D., M.B.A. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Sood, A., Kogan, S., Granick, M.S. (2018). Wound Dressings and Comparative Effectiveness Data. In: Shiffman, M., Low, M. (eds) Chronic Wounds, Wound Dressings and Wound Healing. Recent Clinical Techniques, Results, and Research in Wounds, vol 6. Springer, Cham. https://doi.org/10.1007/15695_2017_97

Download citation

  • DOI: https://doi.org/10.1007/15695_2017_97

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-10697-3

  • Online ISBN: 978-3-030-10698-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics