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Nanohybrid Scaffolds for the Treatment of Diabetic Wounds

  • Veera Venkata Satyanarayana Reddy KarriEmail author
  • Gowthamarajan Kuppusamy
  • Ashish Devidas Wadhwani
  • Rajkumar Malayandi
Chapter
Part of the Recent Clinical Techniques, Results, and Research in Wounds book series

Abstract

Diabetic wounds are the main cause of mortality in patients with diabetes. Recent reports suggest that even though the pathophysiology of diabetic wound is multifactorial, persistent inflammation with infections and lack of tissue regeneration (tissue management) leads to impaired wound healing in diabetes and leaves these wounds in a chronic nonhealing stage. Hence, the aim of this investigation is to formulate drug (curcumin and doxycycline hyclate)-loaded biomimetic collagen–alginate composite nanohybrid scaffolds which have both anti-inflammatory and antibacterial activities for potential tissue regeneration in diabetic wounds. The prepared novel composite nanohybrid scaffolds satisfied the properties of an ideal diabetic wound dressing in terms of mechanical strength, swelling, porosity, biodegradation, biocompatibility, controlled release, cell adhesion, and proliferation with antibacterial anti-inflammatory properties which are crucial for tissue regeneration in diabetic wounds. Hence, this study suggests that the synergistic combination of curcumin, doxycycline hyclate (anti-inflammatory and antibacterial), chitosan (controlled drug carrier, wound healing), collagen (established wound healer), and alginate (biomaterial for regenerative medicine) is a promising strategy to address various pathological manifestations of diabetic wounds and has better wound healing capability.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Veera Venkata Satyanarayana Reddy Karri
    • 1
    • 2
    Email author
  • Gowthamarajan Kuppusamy
    • 1
    • 2
  • Ashish Devidas Wadhwani
    • 3
    • 3
  • Rajkumar Malayandi
    • 4
  1. 1.Department of PharmaceuticsJSS College of PharmacyOotacamundIndia
  2. 2.Jagadguru Sri Shivarathreeshwara UniversityMysuruIndia
  3. 3.Department of Pharmaceutical Biotechnology, JSS College of PharmacyOotacamundIndia
  4. 4.Pharmacokinetic Research and Development, Sun Pharmaceutical Industries Ltd.Village TandaljaIndia

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