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Recent Progress in Biomedical Applications of Chitosan Derivatives as Gene Carrier

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Chitosan for Biomaterials IV

Part of the book series: Advances in Polymer Science ((POLYMER,volume 288))

Abstract

Appropriate gene carriers are vital components of gene therapy for treating numerous intractable diseases. Compared with viral carriers, non-viral carriers exhibit lower immunogenicity and higher biosafety, which have received increasing attention. In particular, among non-viral vectors, gene vectors based on chitosan derivatives are considered a promising gene therapy tool and have been extensively studied due to the biocompatibility, biodegradability, and modifiability of chitosan. In this review, we first discussed the influence of chitosan parameters on the efficiency of gene therapy. More importantly, we summarized the recent research progress in various diseases of chitosan derivatives to deliver different gene therapy substances including plasmid (pDNA), short interfering RNA (siRNA), short hairpin RNA (shRNA), microRNA (miRNA), and clustered regularly interspaced short palindromic repeats-associated endonuclease 9 (CRISPER-Cas9) system. Finally, the current challenges and future directions of chitosan derivatives as gene carriers are also proposed.

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Author notes

  1. Pu-Song Zhao, Yi Wang, and Wenshuang Sun contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China

    Pu-Song Zhao, Yi Wang, Lian-Yu Qi, Li-Fan Hu, Tian-Jiao Zhou, Lei Xing & Hu-Lin Jiang

  2. Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing, China

    Yi Wang, Lei Xing & Hu-Lin Jiang

  3. Department of Orthopedics, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China

    Wenshuang Sun & Chengjun Li

  4. Department of Plastic Surgery, Institute of Dermatology and Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA

    Ki-Hyun Cho

  5. Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, South Korea

    Chong-Su Cho

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  1. Pu-Song Zhao
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Correspondence to Chong-Su Cho .

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  1. Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (University), Kochi, India

    R. Jayakumar

  2. Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai, India

    M. Prabaharan

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Zhao, PS. et al. (2021). Recent Progress in Biomedical Applications of Chitosan Derivatives as Gene Carrier. In: Jayakumar, R., Prabaharan, M. (eds) Chitosan for Biomaterials IV. Advances in Polymer Science, vol 288. Springer, Cham. https://doi.org/10.1007/12_2021_106

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