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Application of Chitosan and Its Derivatives in Transdermal Drug Delivery

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Chitosan for Biomaterials IV

Part of the book series: Advances in Polymer Science ((POLYMER,volume 288))

Abstract

Chitosan is a natural polymer having much use in drug delivery applications. The polymer is characterized by its biocompatibility, biodegradability, muco-adhesiveness, antimicrobial activity, non-toxicity and positive charge. Insolubility of chitosan in water and other common organic solvents limits its utility. This problem can be solved by chemical modification of its reactive functional groups; NH2 and –OH to form derivatives with improved solubility. The transdermal drug delivery systems which can control the drug release process have got substantial importance in drug delivery research areas. Chitosan and its derivatives are reported to enhance the skin permeability via a variety of molecular mechanisms. Low molecular weight chitosan is often employed as permeability enhancer in transdermal drug delivery system (TDDS). Various chitosan based transdermal drug delivery systems like composite films, vesicular systems, dendrimers, microspheres, microneedles and other nanocarriers like nanoparticles, nanogel, nanoemulsion, nanolipid carriers with benefits achieved are detailed in this review.

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References

  1. Antosova Z, Mackova M, Kral V, Macek T (2009) Therapeutic application of peptides and proteins: parenteral forever? Trends Biotechnol 27:628–635

    Article  CAS  PubMed  Google Scholar 

  2. Grenha A, Carrion-Recio D, Teijeiro-Osorio D, Seijo B, Remuñán-López C (2008) Nano and micro-particulate carriers for pulmonary drug delivery. In: Ravi Kumar MNV (ed) Handbook of particulate drug delivery, vol 2. American Scientific Publishers, Valencia, pp 165–192

    Google Scholar 

  3. DiMasi JA, Hansen RW, Grabowski HG (2003) The price of innovation: new estimates of drug development costs. J Health Econ 22:151–185

    Article  PubMed  Google Scholar 

  4. Langer R (1998) Drug delivery and targeting. Nature 392:5–10

    CAS  PubMed  Google Scholar 

  5. Andreas BS, Sarah D (2012) Chitosan-based drug delivery systems. Eur J Pharm Biopharm 81:463–469

    Article  CAS  Google Scholar 

  6. Eugene K, Lee YL (2003) Implantable applications of chitin and chitosan. Biomaterials 24:2339–2234

    Article  CAS  Google Scholar 

  7. Ehrlich H, Steck E (2010) Three-dimensional chitin-based scaffolds from Verongida sponges (Demospongiae: Porifera). Part II: biomimetic potential and applications. Int J Biol Macromol 47:141–145

    Article  CAS  PubMed  Google Scholar 

  8. Mohandas A, Rangasamy J (2021) Nanocurcumin and arginine entrapped injectable chitosan hydrogel for restoration of hypoxia induced endothelial dysfunction. Int J Biol Macromol 166:471–482

    Article  CAS  PubMed  Google Scholar 

  9. Nivedhitha Sundaram M, Deepthi S, Mony U, Shalumon KT, Chen JP, Jayakumar R (2019) Chitosan hydrogel scaffold reinforced with twisted poly(L lactic acid) aligned microfibrous bundle to mimic tendon extracellular matrix. Int J Biol Macromol 122:37–44

    Article  CAS  PubMed  Google Scholar 

  10. Mohandas A, Sun W, Nimal TR, Shankarappa SA, Hwang NS, Jayakumar R (2018) Injectable chitosan-fibrin/nanocurcumin composite hydrogel for the enhancement of angiogenesis. Res Chem Intermed 44:4873–4887

    Article  CAS  Google Scholar 

  11. Anjana J, Mohandas A, Seethalakshmy S, Suresh MK, Menon R, Biswas R, Jayakumar R (2018) Bi-layered nanocomposite bandages for controlling microbial infections and overproduction of matrix metalloproteinase activity. Int J Biol Macromol 110:124–132

    Article  CAS  PubMed  Google Scholar 

  12. Deepthi S, Nivedhitha Sundaram M, Deepti Kadavan J, Jayakumar R (2016) Layered chitosan-collagen hydrogel/aligned PLLA nanofiber construct for flexor tendon regeneration. Carbohydr Polym 153:492–500

    Article  CAS  PubMed  Google Scholar 

  13. Vignesh S, Sivashanmugam A, Annapoorna M, Janarthanan R, Subramania I, Shantikumar VN, Jayakumar R (2018) Injectable deferoxamine nanoparticles loaded chitosan-hyaluronic acid coacervate hydrogel for therapeutic angiogenesis. Colloids Surf B Biointerfaces 161:129–138

    Article  CAS  Google Scholar 

  14. Anisha BS, Sankar D, Mohandas A, Chennazhi KP, Nair SV, Jayakumar R (2013) Chitosan-hyaluronan/nano chondroitin sulfate ternary composite sponges for medical use. Carbohydr Polym 92:1470–1476

    Article  CAS  PubMed  Google Scholar 

  15. Deepthi S, Venkatesan J, Kim SK, Bumgardner JD, Jayakumar R (2016) An overview of chitin or chitosan/nano ceramic composite scaffolds for bone tissue engineering. Int J Biol Macromol 93:1338–1353

    Article  CAS  PubMed  Google Scholar 

  16. Rajitha P, Gopinath D, Biswas R, Sabitha M, Jayakumar R (2016) Chitosan nanoparticles in drug therapy of infectious and inflammatory diseases. Expert Opin Drug Deliv 13:1177–1194

    Article  CAS  PubMed  Google Scholar 

  17. Ravi Kumar MN (2000) A review of chitin and chitosan applications. React Funct Polym 4:1–27

    Article  Google Scholar 

  18. Zikakis JP (1984) Chitin, chitosan and related enzymes, negatively charged lipids, fats and bile acids. Academic Press, Orlando, p 97

    Google Scholar 

  19. Mass WA, Mass A, Tighe B (1998) A review of biodegradable polymers: uses, current developments in the synthesis and characterization of biodegradable polyesters. Blends of biodegradable polymers and recent advances in biodegradation. Polym Int 47:89

    Article  Google Scholar 

  20. Mohamed NA, Sabaa MW, El-Ghandour AH, Abdel-Aziz MM, Abdel-Gawad OF (2013) Quarternized N-substituted carboxymethyl chitosan derivatives as antimicrobial agents. Int J Biol Macromol 60:156–164

    Article  CAS  PubMed  Google Scholar 

  21. Wang W, Meng Q, Li Q, Liu J, Zhou M, Jin Z, Zhao K (2020) Chitosan derivatives and their application in biomedicine. Int J Mol Sci 21:1–26

    Google Scholar 

  22. Li H, Zhang Z, Bao X, Xu G, Yao P (2018) Fatty acid and quaternary ammonium modified chitosan nanoparticles for insulin delivery. Colloids Surf B Biointerfaces 170:136–143

    Article  CAS  PubMed  Google Scholar 

  23. Milosavljević NB, Milašinović NZ, Popović IG, Filipović JM, Kalagasidis Krušić MT (2011) Preparation and characterization of pH-sensitive hydrogels based on chitosan, itaconic acid and methacrylic acid. Polym Int 60:443–452

    Article  CAS  Google Scholar 

  24. Shastri DH (2017) Thiolated chitosan: a boon to ocular delivery of therapeutics. MOJBB 3:34–37

    Article  Google Scholar 

  25. Tian Q, Zhang CN, Wang XH, Wang W, Huang W, Cha RT, Wang CH, Yuan Z, Liu M, Wan HY, Tang H (2010) Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery. Biomaterials 31:4748–4756

    Article  CAS  PubMed  Google Scholar 

  26. Zhao P, Wang H, Yu M, Liao Z, Wang X, Zhang F, Ji W, Wu B, Han J, Zhang H, Wang H, Chang J, Niu R (2012) Paclitaxel loaded folic acid targeted nanoparticles of mixed lipid-shell and polymer-core: in vitro and in vivo evaluation. Eur J Pharm Biopharm 81:248–256

    Article  CAS  PubMed  Google Scholar 

  27. Kumar Singh Yadav H, Shivakumar HG (2012) In vitro and in vivo evaluation of pH-sensitive hydrogels of carboxymethyl chitosan for intestinal delivery of theophylline. ISRN Pharm 2012:1–9

    Google Scholar 

  28. Sugimoto M, Morimoto M, Sashiwa H, Saimoto H, Shigemasa Y (1998) Preparation and characterization of water-soluble chitin and chitosan derivatives. Carbohydr Polym 36:49–59

    Article  CAS  Google Scholar 

  29. Qin Y, Xing R, Liu S, Li K, Meng X, Li R, Cui J, Li B, Li P (2012) Novel thiosemicarbazone chitosan derivatives: preparation, characterization, and antifungal activity. Carbohydr Polym 87:2664–2670

    Article  CAS  Google Scholar 

  30. Piegat A, Goszczyńska A, Idzik T, Niemczyk A (2019) The importance of reaction conditions on the chemical structure of N, O-acylated chitosan derivatives. Molecules 24:1–16

    Article  CAS  Google Scholar 

  31. Deepthi S, Jeevitha K, Nivedhitha Sundaram M, Chennazhi KP, Jayakumar R (2015) Chitosan-hyaluronic acid hydrogel coated poly(caprolactone) multiscale bilayer scaffold for ligament regeneration. Chem Eng Technol 260:478–485

    Article  CAS  Google Scholar 

  32. Mohandas A, Anisha BS, Chennazhi KP, Jayakumar R (2015) Chitosan-hyaluronic acid/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds. Colloids Surf B Biointerfaces 127:105–113

    Article  CAS  PubMed  Google Scholar 

  33. Sundaram MN, Sowmya S, Deepthi S, Bumgardener JD, Jayakumar R (2016) Bilayered construct for simultaneous regeneration of alveolar bone and periodontal ligament. J Biomed Mater Res B Appl Biomater 104:761–770

    Article  CAS  Google Scholar 

  34. Sivashanmugam A, Charoenlarp P, Deepthi S, Rajendran A, Nair SV, Iseki S, Jayakumar R (2017) Injectable shear-thinning CaSO4/FGF-18-incorporated chitin-PLGA hydrogel enhances bone regeneration in mice cranial bone defect model. ACS Appl Mater Interfaces 9:42639–42652

    Article  CAS  PubMed  Google Scholar 

  35. Deepthi S, Abdul Gafoor AA, Sivashanmugam A, Nair SV, Jayakumar R (2016) Nanostrontium ranelate incorporated injectable hydrogel enhanced matrix production supporting chondrogenesis in vitro. J Mater Chem B 4:4092–4103

    Article  CAS  PubMed  Google Scholar 

  36. Debasish S, Sarmila S, Priyanka M, Sasmal S, Nayak PL (2009) Chitosan: a new versatile bio-polymer for various applications. Des Monomers Polym 12:377–404

    Article  CAS  Google Scholar 

  37. Badri W, Eddabra R, Fessi H, Elaissari A (2014) Biodegradable polymer based nanoparticles: dermal and transdermal drug delivery. J Colloid Sci Biotechnol 3:141–149

    Article  CAS  Google Scholar 

  38. Ahmed TA, Aljaeid BM (2016) Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery. Drug Des Dev Ther 10:483–507

    Article  CAS  Google Scholar 

  39. Maji P, Gandhi A, Jana S, Maji N (2013) Preparation and characterization of maleic anhydride cross-linked chitosan-polyvinyl alcohol hydrogel matrix transdermal patch. J PharmaSciTech 2:62–67

    Google Scholar 

  40. Saidin NM, Anuar NK, Meor Mohd Affandi MMR (2018) Roles of polysaccharides in transdermal drug delivery system and future prospects. J Appl Pharm Sci 8:141–157

    CAS  Google Scholar 

  41. Ahmad Z, Khan MI, Siddique MI, Sarwar HS, Shahnaz G, Hussain SZ, Bukhari NI, Hussain I, Sohail MF (2020) Fabrication and characterization of thiolated chitosan microneedle patch for transdermal delivery of tacrolimus. AAPS Pharm Sci Tech 21:1–12

    Article  CAS  Google Scholar 

  42. Allena RT, Yadav HKS, Sandina S, Sarat Chandra Prasad M (2012) Preparation and evaluation of transdermal patches of metformin hydrochloride using natural polymer for sustained release. Int J Pharm Pharm Sci 4:297–302

    CAS  Google Scholar 

  43. Sadhasivam L, Dey N, Francis AP, Devasena T (2015) Transdermal patches of chitosan nanoparticles for insulin delivery. Int J Pharm Pharm Sci 7:84–88

    CAS  Google Scholar 

  44. Laxman JR, Pallavi A, Vyankatrao YA, Varsha GG, Vyankatrao PM, Nawaj SS (2020) The pharmaceutical application of sulfoxy amine chitosan in design, development and evaluation of transdermal drug delivery of gliclazide. J Pharm Res Int 32:145–161

    Article  CAS  Google Scholar 

  45. Yadav AV, Urade MN (2019) Formulation and evaluation of chitosan based transdermal patches of lornoxicam for prolonged drug release and to study the effect of permeation enhancer. Indian J Pharm Educ Res 53:88–96

    Article  CAS  Google Scholar 

  46. Tran TTD, Tran PHL (2019) Controlled release film forming systems in drug delivery: the potential for efficient drug delivery. Pharmaceutics 11:1–16

    Article  Google Scholar 

  47. Jahit IS, Nazmi NN, Isa MI, Sarbon NM (2016) Preparation and physical properties of gelatin/CMC/chitosan composite films as affected by drying temperature. Int Food Res J 23:1068–1074

    CAS  Google Scholar 

  48. Crouvisier-Urion K, Bodart PR, Winckler P, Raya J, Gougeon RD, Cayot P, Domenek S, Debeaufort F, Karbowiak T (2016) Biobased composite films from chitosan and lignin: antioxidant activity related to structure and moisture. ACS Sustain Chem Eng 4:6371–6381

    Article  CAS  Google Scholar 

  49. Nithya S, Nimal TR, Baranwal G, Suresh MK, Anju CP, Anil Kumar V, Gopi Mohan C, Jayakumar R, Biswas R (2018) Preparation, characterization and efficacy of lysostaphin-chitosan gel against Staphylococcus aureus. Int J Biol Macromol 110:157–166

    Article  CAS  PubMed  Google Scholar 

  50. Elbi S, Nimal TR, Rajan VK, Baranwal G, Biswas R, Jayakumar R, Sathianarayanan S (2017) Fucoidan coated ciprofloxacin loaded chitosan nanoparticles for the treatment of intracellular and biofilm infections of Salmonella. Colloids Surf B Biointerfaces 160:40–47

    Article  CAS  Google Scholar 

  51. Thattaruparambil Raveendran N, Mohandas A, Ramachandran Menon R, Somasekharan Menon A, Biswas R, Jayakumar R (2019) Ciprofloxacin-and fluconazole-containing fibrin-nanoparticle-incorporated chitosan bandages for the treatment of polymicrobial wound infections. ACS Appl Bio Mater 2:243–254

    Article  CAS  PubMed  Google Scholar 

  52. Mohandas A, Deepthi S, Biswas R, Jayakumar R (2018) Chitosan based metallic nanocomposite scaffolds as antimicrobial wound dressings. Bioact Mater 3:267–277

    Article  PubMed  Google Scholar 

  53. Nimal TR, Baranwal G, Bavya MC, Biswas R, Jayakumar R (2016) Anti-staphylococcal activity of injectable nano tigecycline/chitosan-PRP composite hydrogel using Drosophila melanogaster model for infectious wounds. ACS Appl Mater Interfaces 8:22074–22083

    Article  CAS  PubMed  Google Scholar 

  54. Martínez-Camacho AP, Cortez-Rocha MO, Ezquerra-Brauer JM, Graciano-Verdugo AZ, Rodriguez-Félix F, Castillo-Ortega MM, Yépiz-Gómez MS, Plascencia-Jatomea M (2010) Chitosan composite films: thermal, structural, mechanical and antifungal properties. Carbohydr Polym 82:305–315

    Article  CAS  Google Scholar 

  55. Chen L, Tang CY, Ning NY, Wang CY, Fu Q, Zhang Q (2009) Preparation and properties of chitosan/lignin composite films. Chin J Polym Sci 27:739–746

    Article  CAS  Google Scholar 

  56. Yang J, Kwon GJ, Hwang K, Kim DY (2018) Cellulose-chitosan antibacterial composite films prepared from LiBr solution. Polymers 10:1–7

    Article  Google Scholar 

  57. Tanabe T, Okitsu N, Tachibana A, Yamauchi K (2002) Preparation and characterization of keratin-chitosan composite film. Biomaterials 23:817–825

    Article  CAS  PubMed  Google Scholar 

  58. Xu YX, Kim KM, Hanna MA, Nag D (2005) Chitosan-starch composite film: preparation and characterization. Ind Crop Prod 21:185–192

    Article  CAS  Google Scholar 

  59. Maria VD, Bernal C, Francois NJ (2016) Development of biodegradable films based on chitosan/glycerol blends suitable for biomedical applications. J Tissue Sci Eng 7:1–9

    Article  CAS  Google Scholar 

  60. Srithar S, Rao SS (2019) Capsicum-extract blended chitosan composite films and studying their antibacterial properties. Bull Mater Sci 42:1–5

    Article  CAS  Google Scholar 

  61. Yuvaraj S, Rajeswari N (2018) Chitosan/modified banana epidermis starch composite films for food packaging applications. J Appl Packag Res 10:14–27

    Google Scholar 

  62. Rahmi (2018) Preparation of chitosan composite film using activated carbon from oil-palm empty fruit bunch for Cd2+ removal from waters. IOP Conf Ser Mater Sci Eng 434:1–8

    Article  Google Scholar 

  63. Thakur G, Singh A, Singh I (2016) Formulation and evaluation of transdermal composite films of chitosan-montmorillonite for the delivery of curcumin. Int J Pharm Investig 6:23–31

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Paul S, Jayan A, Sasikumar CS (2015) Physical, chemical and biological studies of gelatin/chitosan based transdermal films with embedded silver nanoparticles. Asian Pacific J Trop Dis 5:975–986

    Article  CAS  Google Scholar 

  65. Oh DW, Kang JH, Lee HJ, Han SD, Kang MH, Kwon YH, Jun JH, Kim DW, Rhee YS, Kim JY, Park ES, Park CW (2017) Formulation and in vitro/in vivo evaluation of chitosan-based film forming gel containing ketoprofen. Drug Deliv 24:1056–1066

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Behera DK, Mishra K (2019) Formulation and evaluation of chitosan-polypyrrole nanocomposites for controlled release of anticancer drug doxorubicin. Int J App Pharm 11:247–253

    Article  CAS  Google Scholar 

  67. Wahid A, Sridhar BK, Shivakumar S (2008) Preparation and evaluation of transdermal drug delivery system of etoricoxib using modified chitosan. Indian J Pharm Sci 70:455–460

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  68. Hima BT, Vidyavathi M, Kavitha K, Sastry T, Suresh KR (2010) Preparation and evaluation of ciprofloxacin loaded chitosan-gelatin composite films for wound healing activity. Int J Drug Deliv 2:173–182

    Article  CAS  Google Scholar 

  69. Cui Z, Zheng Z, Lin L, Si J, Wang Q, Peng X, Chen W (2018) Electrospinning and crosslinking of polyvinyl alcohol/chitosan composite nanofiber for transdermal drug delivery. Adv Polym Technol 37:1917–1928

    Article  CAS  Google Scholar 

  70. Bavarsad N, Kouchak M, Mohamadipour P, Sadeghi-Nejad B (2016) Preparation and physicochemical characterization of topical chitosan-based film containing griseofulvin-loaded liposomes. J Adv Pharm Technol Res 7:91–98

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Devi PM, Menda JP, Reddy T, Deepika R, Sastry TP (2014) Preparation and characterization of wound healing composites of chitosan, Aloe vera and Calendula officinalis – a comparative study. Am J Phytomed Clin Ther 2:61–76

    Google Scholar 

  72. Khan G, Yadav SK, Patel RR, Nath G, Bansal M, Mishra B (2016) Development and evaluation of biodegradable chitosan films of metronidazole and levofloxacin for the management of periodontitis. AAPS PharmSciTech 17:1312–1325

    Article  CAS  PubMed  Google Scholar 

  73. Kouchak M, Ameri A, Naseri B, Kargar Boldaji S (2014) Chitosan and polyvinyl alcohol composite films containing nitrofurazone: preparation and evaluation. Iran J Basic Med Sci 17:14–20

    CAS  PubMed  PubMed Central  Google Scholar 

  74. Saleem MA, Naheed MD, Murali YD, Jaydeep P, Dhaval M (2012) Preparation and evaluation of mupirocin loaded polymer composite films. J Drug Deliv Ther 2:167–172

    CAS  Google Scholar 

  75. Can AS, Erdal MS, Güngör S, Özsoy Y (2013) Optimization and characterization of chitosan films for transdermal delivery of ondansetron. Molecules 18:5455–5471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Hemant KSY, Shivakumar HG (2010) Development of chitosan acetate films for transdermal delivery of propranolol hydrochloride. Trop J Pharm Res 9:197–203

    Article  CAS  Google Scholar 

  77. Jeon S, Yoo CY, Park SN (2015) Improved stability and skin permeability of sodium hyaluronate-chitosan multilayered liposomes by Layer-by-Layer electrostatic deposition for quercetin delivery. Colloids Surf B Biointerfaces 129:7–14

    Article  CAS  PubMed  Google Scholar 

  78. Dong W, Ye J, Wang W, Yang Y, Wang H, Sun T, Gao L, Liu Y (2020) Self-assembled lecithin/chitosan nanoparticles based on phospholipid complex: a feasible strategy to improve entrapment efficiency and transdermal delivery of poorly lipophilic drug. Int J Nanomed 15:5629–5643

    Article  CAS  Google Scholar 

  79. Park SN, Jo NR, Jeon SH (2014) Chitosan-coated liposomes for enhanced skin permeation of resveratrol. J Ind Eng Chem 20:1481–1485

    Article  CAS  Google Scholar 

  80. Arora R, Jain CP (2016) Advances in niosome as a drug carrier: a review. Asian J Pharm 1:29–39

    Google Scholar 

  81. Lakshmi PK, Bhaskaran S (2011) Phase II study of topical niosomal urea gel – an adjuvant in the treatment of psoriasis. Int J Pharm Sci Rev Res 7:1–7

    CAS  Google Scholar 

  82. Auda SH, Fathalla D, Fetih G, El-Badry M, Shakeel F (2016) Niosomes as transdermal drug delivery system for celecoxib: in vitro and in vivo studies. Polym Bull 73:1229–1245

    Article  CAS  Google Scholar 

  83. Osanloo M, Assadpour S, Mehravaran A, Abastabar M, Akhtari J (2018) Niosome-loaded antifungal drugs as an effective nanocarrier system: a mini review. Curr Med Mycol 4:31–36

    PubMed  PubMed Central  Google Scholar 

  84. Lakshmi PK, Devi GS, Bhaskaran S, Sacchidanand S (2007) Niosomal methotrexate gel in the treatment of localized psoriasis: phase I and phase II studies. Indian J Dermatol Venereol Leprol 73:157–161

    Article  CAS  PubMed  Google Scholar 

  85. Abdelbary AA, Abou Ghaly MHH (2015) Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box–Behnken design, in-vitro evaluation and in-vivo skin deposition study. Int J Pharm 485:235–243

    Article  CAS  PubMed  Google Scholar 

  86. Sohrabi S, Haeri A, Mahboubi A, Mortazavi A, Dadashzadeh S (2016) Chitosan gel-embedded moxifloxacin niosomes: an efficient antimicrobial hybrid system for burn infection. Int J Biol Macromol 85:625–633

    Article  CAS  PubMed  Google Scholar 

  87. Tiwari RK, Chauhan NS, Yogesh HS (2010) Ethosomes: a potential carries for transdermal drug. Int J Drug Dev Res 2:448–452

    CAS  Google Scholar 

  88. Kumar L, Verma S, Singh K, Prasad DN, Jain AK (2016) Ethanol based vesicular carriers in transdermal drug delivery: nanoethosomes and transethosomes in focus. NanoWorld J 2:41–51

    Article  CAS  Google Scholar 

  89. Nasr S, Rady M, Gomaa I, Syrovet T, Simmet T, Fayad W, Kader MA (2019) Ethosomes and lipid-coated chitosan nanocarriers for skin delivery of a chlorophyll derivative: a potential treatment of squamous cell carcinoma by photodynamic therapy. Int J Pharm 568:1–11

    Article  CAS  Google Scholar 

  90. Niu XQ, Zhang DP, Bian Q, Feng XF, Li H, Rao YF, Shen YM, Geng FN, Yuan AR, Ying XY, Gao JQ (2019) Mechanism investigation of ethosomes transdermal permeation. Int J Pharm X 1:1–13

    Google Scholar 

  91. Rabia S, Khaleeq N, Batool S, Dar MJ, Kim DW, Din FU, Khan GM (2020) Rifampicin-loaded nanotransferosomal gel for treatment of cutaneous leishmaniasis: passive targeting via topical route. Nanomedicine 15:183–203

    Article  CAS  PubMed  Google Scholar 

  92. Opatha SAT, Titapiwatanakun V, Chutoprapat R (2020) Transfersomes: a promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics 12:1–23

    Article  CAS  Google Scholar 

  93. Fernández-García R, Lalatsa A, Statts L, Bolás-Fernández F, Ballesteros MP, Serrano DR (2020) Transferosomes as nanocarriers for drugs across the skin: quality by design from lab to industrial scale. Int J Pharm 573:1–43

    Article  CAS  Google Scholar 

  94. Rai S, Pandey V, Rai G (2017) Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art. Nano Rev Exp 8:1–17

    Article  CAS  Google Scholar 

  95. Mengoni T, Adrian M, Pereira S, Santos-Carballal B, Kaiser M, Goycoolea FM (2017) A chitosan-based liposome formulation enhances the in vitrowound healing efficacy of substance P neuropeptide. Pharmaceutics 9:1–17

    Article  CAS  Google Scholar 

  96. Al-najjar BY, Hussain SA (2017) Chitosan microspheres for the delivery of chemotherapeutic agents: paclitaxel as a model. Asian J Pharm Clin Res 10:1–5

    Article  CAS  Google Scholar 

  97. Shivashankar M, Mandal BK (2013) Design and evaluation of chitosan-based novel pHSensitive drug carrier for sustained release of cefixime. Trop J Pharm Res 12:155–161

    Google Scholar 

  98. Zhao F, Zhang H, Wu Y, Wang D, Zhang Y (2020) Preparation and performance evaluation of polymeric microspheres used for profile control of low-permeability reservoirs. J Chem 2020:1–11

    Google Scholar 

  99. Mandal A, Majumdar A, Malviya N (2018) Formulation and evaluation of chitosan microspheres for the topical delivery of itraconazole. J Pharm Res 12:890–894

    CAS  Google Scholar 

  100. Mitra A, Dey B (2011) Chitosan microspheres in novel drug delivery systems. Indian J Pharm Sci 73:355–366

    CAS  PubMed  PubMed Central  Google Scholar 

  101. Huang G, Liu Y, Chen L (2017) Chitosan and its derivatives as vehicles for drug delivery. Drug Deliv 24:108–113

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  102. Liu T, Luo G, Xing M (2020) Biomedical applications of polymeric microneedles for transdermal therapeutic delivery and diagnosis: current status and future perspectives. Adv Ther 3:1–15

    Google Scholar 

  103. Ahmed Saeed AL, Japairai K, Mahmood S, Hamed Almurisi S, Reddy Venugopal J, Rebhi Hilles A, Azmana M, Raman S (2020) Current trends in polymer microneedle for transdermal drug delivery. Int J Pharm 587:1–14

    Google Scholar 

  104. Demir YK, Akan Z, Kerimoglu O (2013) Characterization of polymeric microneedle arrays for transdermal drug delivery. PLoS One 8:1–9

    Article  Google Scholar 

  105. Chandrasekharan A, Hwang YJ, Seong KY, Park S, Kim S, Yang SY (2019) Acid-treated water-soluble chitosan suitable for microneedle-assisted intracutaneous drug delivery. Pharmaceutics 11:1–14

    Article  CAS  Google Scholar 

  106. Sadeqi A, Nejad HR, Kiaee G, Sonkusale S (2018) Cost-effective fabrication of chitosan microneedles for transdermal drug delivery. Annu Int Conf IEEE Eng Med Biol Soc 2018:5737–5740

    PubMed  Google Scholar 

  107. Chen MY, Chen YY, Tsai HT, Tzai TS, Chen MC, Tsai YS (2017) Transdermal delivery of luteinizing hormone-releasing hormone with chitosan microneedles: a promising tool for androgen deprivation therapy. Anticancer Res 37:6791–6797

    CAS  PubMed  Google Scholar 

  108. Chen MC, Ling MH, Lai KY, Pramudityo E (2012) Chitosan microneedle patches for sustained transdermal delivery of macromolecules. Biomacromolecules 13:4022–4031

    Article  CAS  PubMed  Google Scholar 

  109. Badhe RV, Adkine D, Godse A (2020) Development of PLA and BSA layered coated chitosan microneedles using novel bees wax mould. Turk J Pharm Sci 17:27–35

    CAS  Google Scholar 

  110. Mei CC, Ling M-H, Lai K-Y, Pramudityo E (2012) Chitosan microneedle patches for sustained transdermal delivery of macromolecules. Biomacromolecules 13:4022–4031

    Google Scholar 

  111. Xu Q, Wang C-H, Wayne Pack D (2010) Polymeric carriers for gene delivery: chitosan and poly(amidoamine) dendrimers. Curr Pharm Des 16:2350–2368

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. Duan XD, Ji CJ, Nie L (2015) Formulation and development of dendrimer-based transdermal patches of meloxicam for the management of arthritis. Trop J Pharm Res 14:583–590

    Article  CAS  Google Scholar 

  113. Tripathy S, Das MK (2013) Dendrimers and their applications as novel drug delivery carriers. J Appl Pharm Sci 3:142–149

    Google Scholar 

  114. Wang J, He H, Cooper RC, Gui Q, Yang H (2019) Drug-conjugated dendrimer hydrogel enables sustained drug release via a self-cleaving mechanism. Mol Pharm 16:1874–1880

    Article  CAS  PubMed  Google Scholar 

  115. Liu KC, Yeo Y (2013) Zwitterionic chitosan-polyamidoamine dendrimer complex nanoparticles as a ph-sensitive drug carrier. Mol Pharm 10:1695–1704

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Karen CL, Yoon Y (2013) Zwitterionic chitosan–polyamidoamine dendrimer complex nanoparticles as a pH-sensitive drug carrier. Mol Pharm 10:1695–1704

    Google Scholar 

  117. Leng ZH, Zhuang QF, Li YC, He Z, Chen Z, Huang SP, Jia HY, Zhou JW, Liu Y, Du LB (2013) Polyamidoamine dendrimer conjugated chitosan nanoparticles for the delivery of methotrexate. Carbohydr Polym 98:1173–1178

    Article  CAS  PubMed  Google Scholar 

  118. El-Fekya GS, El-Bannac ST, El-Bahyc GS, Abdelrazeke EM, Mustafa K (2017) Alginate coated chitosan nanogel for the controlled topical delivery of silver sulfadiazine. Carbohydr Polym 177:194–202

    Article  CAS  Google Scholar 

  119. Inayat BP, Rashmi D, Wahid A (2019) Formulation and evaluation of ketoprofen loaded chitosan nanogel for pain management: ex-vivo and In-vivo study. Ars Pharm 60:101–108

    Google Scholar 

  120. Amos A, Sureya I, Adeola KM (2015) Ex vivo skin permeation and retention studies on chitosan-ibuprofen-gellan ternary nanogel prepared by in situ ionic gelation technique – a tool for controlled transdermal delivery of ibuprofen. Int J Pharm 490:1–2

    CAS  Google Scholar 

  121. Samah AA, Ali D, Kaixiang Z, Dongmei C, Chao L, Kuiyu M, Muhammad KM, Saeed A, Lingli H, Shuyu X (2020) Designing, structural determination and biological effects of rifaximin loaded chitosan-carboxymethyl chitosan nanogel. Carbohydr Polym 248:116782

    Article  CAS  Google Scholar 

  122. Yilmaz Atay H (2020) Antibacterial activity of chitosan-based systems. Funct Chitosan:457–489

    Google Scholar 

  123. Roberta B, Elisa P, Daniel B, de Rayssa Julliane C (2010) Chitosan nanoemulsions of cold-pressed orange essential oil to preserve fruit juices. Int J Food Microbiol 331:108786

    Google Scholar 

  124. Bonferoni MC, Riva F, Invernizzi A, Dellera E, Sandri G, Rossi S, Marrubini G, Bruni G, Vigani B, Caramella C, Ferrari F (2018) Alpha tocopherol loaded chitosan oleate nanoemulsions for wound healing. Evaluation on cell lines and ex vivo human biopsies, and stabilization in spray dried Trojan microparticles. Eur J Pharm Biopharm 123:31–41

    Google Scholar 

  125. Giacone DV, Dartora VFMC, de Matos JKR, Passos JS, Miranda DAG, de Oliveira EA, Lopes LB (2020) Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models. Int J Biol Macromol 165:1055–1065

    Article  CAS  PubMed  Google Scholar 

  126. Sabah HA, Bapi G, Anoop BN, Hira C, Manisha P, Shah Jigar N, Katharigatta NV (2020) Development and optimization of naringenin-loaded chitosan-coated nanoemulsion for topical therapy in wound healing. Pharmaceutics 12:893

    Google Scholar 

  127. Najmeh FL, Negar MK (2019) Preparation and characterization of O/W nanoemulsion with Mint essential oil and Parsley aqueous extract and the presence effect of chitosan. Nanomed Res J 4:48–55

    Google Scholar 

  128. Ae-Jin C, Chul-Jin K, Yong-Jin C, Jae-Kwan H, Chong-Tai K (2011) Characterization of capsaicin-loaded nanoemulsions stabilized with alginate and chitosan by self-assembly. Food Bioproc Tech 4:1119–1126

    Article  CAS  Google Scholar 

  129. Neda N, Hadi V, Parvin Zakeri M (2015) Solid lipid nanoparticles and nanostructured lipid carriers: structure, preparation and application. Adv Pharm Bull 5:305–313

    Article  CAS  Google Scholar 

  130. Randy Chi Fai C, Tzi Bun N, Jack Ho W, Wai Yee C (2015) Chitosan: an update on potential biomedical and pharmaceutical applications. Mar Drugs 13:5156–5186

    Article  CAS  Google Scholar 

  131. Chandy T, Sharma CP (1990) Chitosan-as a biomaterial. Biomater Artif Cells Artif Organs 18:1–24

    Article  CAS  PubMed  Google Scholar 

  132. Norhayati NM, Khalid S, Satyanarayana SMG (2017) Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery. Eur J Pharm Biopharm 117:372–384

    Article  CAS  Google Scholar 

  133. Eid RK, Ashour DS, Essa EA, El Maghraby GM, Arafa MF (2020) Chitosan coated nanostructured lipid carriers for enhanced in vivo efficacy of albendazole against Trichinella spiralis. Carbohydr Polym 232:115826

    Article  PubMed  CAS  Google Scholar 

  134. Renata SR, Rabelo Isabela FO, Vanessa MD, Ana SP, Miriam DH (2018) Chitosan coated nanostructured lipid carriers (NLCs) for loading vitamin D: a physical stability study. Int J Biol Macromol 119:902–912

    Article  CAS  Google Scholar 

  135. Ana G (2012) Chitosan nanoparticles: a survey of preparation methods. J Drug Target 20:291–300

    Article  CAS  Google Scholar 

  136. Wenhao N, Li D, Houjie C, Fahim UK, Lu Y, Xinbing S, Xiaojun S (2018) Topical use of quercetin-loaded chitosan nanoparticles against ultraviolet B radiation. Front Pharmacol 9:826

    Article  CAS  Google Scholar 

  137. Hafiz MB, Mohd Cairul MA, Shiow Fern N, .Haliza K, Sheefat US, Nauman RK (2020) Formulation and evaluation of microwave-modified chitosan-curcumin nanoparticles – a promising nanomaterials platform for skin tissue regeneration applications following burn wounds. Polymers 12:2608.

    Article  CAS  Google Scholar 

  138. Veera Venkata Satyanarayana RK, Gowthamarajan K, Siddhartha VT, Sai Sandeep M, Radhakrishna K, Ashish Devidas W, Shashank M, Kalidhindi Rama SR, Rajkumar M (2016) Curcumin loaded chitosan nanoparticles impregnated into collagen-alginate scaffolds for diabetic wound healing. Int J Biol Macromol 93:1519–1529

    Article  CAS  Google Scholar 

  139. Salma MA, Rania MH, Omaima AS (2018) Tracking the transdermal penetration pathways of optimized curcumin-loaded chitosan nanoparticles via confocal laser scanning microscopy. Int J Biol Macromol 108:753–764

    Article  CAS  Google Scholar 

  140. Yerikala R, Vadhireddy S (2017) Transdermal patch of Ramipril loaded chitosan nanoparticles dispersed in carbopol gel. J Drug Deliv Therapeut 7:56–65

    Google Scholar 

  141. Tao W, Yan Z, Yaping S, Yijie S, Fang L, Chang S, Liang Z (2018) Chitosan nanoparticles loaded hydrogels promote skin wound healing through the modulation of reactive oxygen species, artificial cells. Nanomed Biotechnol 46:S138–S149

    Google Scholar 

  142. Taha UW, Syed NR, Nisar AK (2019) Rosmarinic acid loaded chitosan nanoparticles for wound healing in rats. Int J Pharm Sci:1138–1147

    Google Scholar 

  143. Raida AK, Jingyuan W, Angel En-Miao C, Amy Moon-Jung K, Stephanie Sze ML, Joohee Y (2016) Transdermal delivery of propranolol hydrochloride through chitosan nanoparticles dispersed in mucoadhesive gel. Carbohydr Polym 153:176–186

    Article  CAS  Google Scholar 

  144. Hafner A, Lovric J, Pepic I, Filipovic-Grcic J (2011) Lecithin/chitosan nanoparticles for transdermal delivery of melatonin. J Microencapsul 28:807–815

    Article  CAS  PubMed  Google Scholar 

  145. Lingheswar S, Arul Prakash F (2015) Transdermal patches of chitosan nanoparticles for insulin delivery. Int J Pharm Pharm Sci 7:84–88

    Google Scholar 

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Author notes

  1. Rajitha Panonnummal and Vrinda S. Kumar contributed equally to this work.

Authors and Affiliations

  1. Amrita School of Pharmacy, Amrita Institute of Medical Science and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, India

    Rajitha Panonnummal, Vrinda S. Kumar & M. Sabitha

  2. Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Kochi, India

    R. Jayakumar

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  1. Rajitha Panonnummal
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  2. Vrinda S. Kumar
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  3. R. Jayakumar
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  4. M. Sabitha
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Correspondence to M. Sabitha .

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  1. Centre for Nanosciences and Molecular Medicine, Amrita Vishwa Vidyapeetham (University), Kochi, India

    R. Jayakumar

  2. Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai, India

    M. Prabaharan

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Panonnummal, R., Kumar, V.S., Jayakumar, R., Sabitha, M. (2021). Application of Chitosan and Its Derivatives in Transdermal Drug Delivery. In: Jayakumar, R., Prabaharan, M. (eds) Chitosan for Biomaterials IV. Advances in Polymer Science, vol 288. Springer, Cham. https://doi.org/10.1007/12_2021_102

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