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Hydrophobically Associating Hydrogels with Microphase-Separated Morphologies

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Self-Healing and Self-Recovering Hydrogels

Part of the book series: Advances in Polymer Science ((POLYMER,volume 285))

Abstract

Hydrophobically associating hydrogels based on copolymers of a water-soluble monomer with a fluoroacrylate or fluoromethacrylate possess microphase-separated morphologies that provide unique properties. Physical crosslinks in these hydrogels involve hydrophobic bonds between fluoro(meth)acrylate groups that associate into 2–6-nm-diameter core–shell nanodomains that represent multifunctional crosslinks. These hydrogels exhibit exceptional mechanical properties and fracture toughness values approaching 104 J/m2, are extrudable, and show self-healing behavior of the microstructure. This chapter reviews the characteristics of these microphase-separated, hydrophobically associating hydrogels and discusses potential applications of these materials as injectable in situ forming hydrogels, electrospun fiber mats suitable for tissue scaffolds, controlled drug release, antifreeze materials, and shape memory hydrogels.

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Acknowledgments

This review was derived from the research and journal papers of the following MS and PhD students and postdoctoral research associates from the University of Connecticut and the University of Akron: Sung-Su Bae, Kaushik Chakrabarty, Debashis Debnath, Jinkun Hao, Xing Lu, Matthew Mullarney, Siamak Shams Es-Haghi, Jun Tian, Chao Wang, Fei Wang, Clinton Wiener, and Yiming Yang. We also acknowledge the contributions to this research by Prof. Thomas A. P. Seery (University of Connecticut); Prof. Colleen Pugh (University of Akron (now, Wichita State University); Dr. Masatumi Fukuto and Dr. Ruipeng Li (Brookhaven National Laboratory, Upton, NY); Dr. Christopher White, Dr. Yun Liu, and Dr. Derek Ho (National Institute of Standards and Technology, Gaithersburg, MD); and Prof. Kenneth Shull and Kazi Sadman (Northwestern University). The nanostructure characterization of these hydrogels was enabled by user facilities for SAXS [Complex Materials Scattering (CMS/11-BM) beamline, operated by the National Synchrotron Light Source II and the Center for Functional Nanomaterials, which are US Department of Energy (DOE) Office of Science User Facilities operated for the DOE Office of Science by Brookhaven National Laboratory under Contract No. DE-SC0012704] and SANS (Center for High Resolution Neutron Scattering, a partnership between the National Institute of Standards and Technology and the National Science Foundation under Agreement No. DMR-1508249).

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Authors and Affiliations

  1. Department of Chemical Engineering, The Pennsylvania State University, University Park, PA, USA

    Bryan D. Vogt

  2. Department of Polymer Engineering, University of Akron, Lenox, MA, USA

    R. A. Weiss

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Editors and Affiliations

  1. Laboratory of Soft Matter Science and Engineering, ESPCI Paris - PSL, Paris, France

    Costantino Creton

  2. Department of Chemistry, Istanbul Technical University, Istanbul, Turkey

    Oguz Okay

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Vogt, B.D., Weiss, R.A. (2020). Hydrophobically Associating Hydrogels with Microphase-Separated Morphologies. In: Creton, C., Okay, O. (eds) Self-Healing and Self-Recovering Hydrogels. Advances in Polymer Science, vol 285. Springer, Cham. https://doi.org/10.1007/12_2019_54

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