Advertisement

Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery

  • Hamed Arami
  • Zachary Stephen
  • Omid Veiseh
  • Miqin Zhang
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 243)

Abstract

Iron oxide nanoparticles (IONPs) are a new class of nanomaterials which have attracted extensive interest for application in in vivo magnetic resonance imaging (MRI) due to their intrinsic superparamagnetic and biodegradable properties. Performance of the IONPs is largely dependent upon the properties of their surface coatings, which serve to prevent nanoparticle agglomeration, reduce the risk of immunogenicity, and limit nonspecific cellular uptake. Among the coating materials studied to date, chitosan has drawn considerable attention. Commonly derived from crustacean shells, chitosan is a natural linear polysaccharide and has ample reactive functional groups that can serve as anchors for conjugation of therapeutics, targeting ligands, and imaging agents. Because of these unique attributes, chitosan-coated IONPs are becoming more desirable for cancer imaging and therapy applications. This chapter discusses the current advances and challenges in synthesis of chitosan-coated IONPs, and their subsequent surface modifications for applications in cancer diagnosis and therapy.

Keywords

Cancer Chitosan Drug delivery Gene therapy Imaging Iron oxide Magnetic nanoparticles MRI Nanomedicine 

Notes

Acknowledgments

This work is supported by NIH grants R01EB006043, and R01CA134213. O. Veiseh acknowledges support through the NIH/NCI training grant (T32CA138312).

References

  1. 1.
    Alexis F, Rhee JW, Richie JP, Radovic-Moreno AF, Langer R, Farokhzad OC (2008) Urol Oncol 26:74CrossRefGoogle Scholar
  2. 2.
    Ferrari M (2005) Nat Rev Cancer 5:161CrossRefGoogle Scholar
  3. 3.
    Sun C, Lee JSH, Zhang MQ (2008) Adv Drug Deliv Rev 60:1252CrossRefGoogle Scholar
  4. 4.
    Veiseh O, Gunn JW, Zhang M (2010) Adv Drug Deliv Rev 62:284CrossRefGoogle Scholar
  5. 5.
    Veiseh O, Sun C, Fang C, Bhattarai N, Gunn J, Kievit F, Du K, Pullar B, Lee D, Ellenbogen RG, Olson J, Zhang M (2009) Cancer Res 69:6200CrossRefGoogle Scholar
  6. 6.
    Veiseh O, Kievit FM, Fang C, Mu N, Jana S, Leung MC, Mok H, Ellenbogen RG, Park JO, Zhang MQ (2010) Biomaterials 31:8032CrossRefGoogle Scholar
  7. 7.
    Sun C, Fang C, Stephen Z, Veiseh O, Hansen S, Lee D, Ellenbogen RG, Olson J, Zhang M (2008) Nanomedicine (Lond) 3:495CrossRefGoogle Scholar
  8. 8.
    Kievit FM, Veiseh O, Fang C, Bhattarai N, Lee D, Ellenbogen RG, Zhang MQ (2010) ACS Nano 4:4587CrossRefGoogle Scholar
  9. 9.
    Rachakatla RS, Balivada S, Seo GM, Myers CB, Wang H, Samarakoon TN, Dani R, Pyle M, Kroh FO, Walker B, Leaym X, Koper OB, Chikan V, Bossmann SH, Tamura M, Troyer DL (2010) ACS Nano 4:7093CrossRefGoogle Scholar
  10. 10.
    Singh R, Verma R, Kaushik A, Sumana G, Sood S, Gupta RK, Malhotra BD (2010) Biosens BioelectronGoogle Scholar
  11. 11.
    Zhang Y, Kohler N, Zhang MQ (2002) Biomaterials 23:1553CrossRefGoogle Scholar
  12. 12.
    Griffiths SM, Singh N, Jenkins GJS, Doak SH (2010) Mutagenesis 25:34Google Scholar
  13. 13.
    Lee HJ, Jeong YY, Lee IK, Namgung R, Kim WJ, Yu MK, Jon S, Lee SJ, Park IK (2010) Human Gene Therapy 21:1410Google Scholar
  14. 14.
    Debnath S, Strongin DR (2007) Abstracts of Papers of the American Chemical Society 234:59Google Scholar
  15. 15.
    Park JH, Saravanakumar G, Kim K, Kwon IC (2010) Adv Drug Deliv Rev 62:28CrossRefGoogle Scholar
  16. 16.
    Mao SR, Sun W, Kissel T (2010) Adv Drug Deliv Rev 62:12CrossRefGoogle Scholar
  17. 17.
    Bhattarai N, Gunn J, Zhang MQ (2010) Adv Drug Deliv Rev 62:83CrossRefGoogle Scholar
  18. 18.
    de la Fuente M, Seijo B, Alonso MJ (2008) Macromol Biosci 8:441CrossRefGoogle Scholar
  19. 19.
    Agrawal P, Strijkers GJ, Nicolay K (2010) Adv Drug Deliv Rev 62:42CrossRefGoogle Scholar
  20. 20.
    Kievit FM, Veiseh O, Bhattarai N, Fang C, Gunn JW, Lee D, Ellenbogen RG, Olson JM, Zhang MQ (2009) Adv Funct Mater 19:2244CrossRefGoogle Scholar
  21. 21.
    Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN (2010) Chem Rev 110:2574CrossRefGoogle Scholar
  22. 22.
    Majumder DD, Banerjee R, Ulrichs C, Mewis I, Goswami A (2007) IETE Tech Rev 24:9Google Scholar
  23. 23.
    Teo BK, Sun XH (2006) J Cluster Sci 17:529CrossRefGoogle Scholar
  24. 24.
    Gupta AK, Gupta M (2005) Biomaterials 26:3995CrossRefGoogle Scholar
  25. 25.
    Lefebure S, Dubois E, Cabuil V, Neveu S, Massart R (1998) J Mater Res 13:2975CrossRefGoogle Scholar
  26. 26.
    Laurent S, Forge D, Port M, Roch A, Robic C, Elst LV, Muller RN (2008) Chem Rev 108:2064CrossRefGoogle Scholar
  27. 27.
    Itoh H, Sugimoto T (2003) J Colloid Interface Sci 265:283CrossRefGoogle Scholar
  28. 28.
    Sjogren CE, Brileysaebo K, Hanson M, Johansson C (1994) Magn Reson Med 31:268CrossRefGoogle Scholar
  29. 29.
    Tominaga M, Matsumoto M, Soejima K, Taniguchi I (2006) J Colloid Interface Sci 299:761CrossRefGoogle Scholar
  30. 30.
    Sun SH, Zeng H, Robinson DB, Raoux S, Rice PM, Wang SX, Li GX (2004) J Am Chem Soc 126:273CrossRefGoogle Scholar
  31. 31.
    Fang C, Bhattarai N, Sun C, Zhang MQ (2009) Small 5:1637CrossRefGoogle Scholar
  32. 32.
    Elsabee MZ, Morsi RE, Al-Sabagh AM (2009) Colloids Surf B Biointerfaces 74:1CrossRefGoogle Scholar
  33. 33.
    Honarkar H, Barikani M (2009) Monatsh Chem 140:1403CrossRefGoogle Scholar
  34. 34.
    Cristallini C, Barbani N, Bianchi F, Silvestri D, Guerra GD (2008) Biomed Eng Appl Basis Commun 20:321CrossRefGoogle Scholar
  35. 35.
    Fulzele SV, Satturwar PM, Dorle AK (2003) Eur J Pharm Sci 20:53CrossRefGoogle Scholar
  36. 36.
    Kean T, Thanou M (2010) Adv Drug Deli Rev 62:3CrossRefGoogle Scholar
  37. 37.
    Zan QF, Wang C, Dong LM, Cheng P, Tian JM (2008) Appl Surf Sci 255:401CrossRefGoogle Scholar
  38. 38.
    Custodio CA, Alves CM, Reis RL, Mano JF (2010) J Tissue Eng Regen Med 4:316CrossRefGoogle Scholar
  39. 39.
    Liu WG, De Yao K (2002) J Control Release 83:1CrossRefGoogle Scholar
  40. 40.
    van der Lubben IM, Verhoef JC, Borchard G, Junginger HE (2001) Eur J Pharm Sci 14:201CrossRefGoogle Scholar
  41. 41.
    Chang YC, Chen DGH (2005) Macromol Biosci 5:254CrossRefGoogle Scholar
  42. 42.
    Muzzarelli RAA (1988) Carbohydr Polym 8:1CrossRefGoogle Scholar
  43. 43.
    Lillo LE, Matsuhiro B (1997) Carbohydr Polym 34:397CrossRefGoogle Scholar
  44. 44.
    Muzzarelli RAA, Tanfani F, Emanuelli M, Mariotti S (1982) Carbohydr Res 107:199CrossRefGoogle Scholar
  45. 45.
    Jia ZS, Shen DF, Xu WL (2001) Carbohydr Res 333:1CrossRefGoogle Scholar
  46. 46.
    Holme KR, Perlin AS (1997) Carbohydr Res 302:7CrossRefGoogle Scholar
  47. 47.
    Xie WM, Xu PX, Wang W, Liu Q (2002) Carbohydr Polym 50:35CrossRefGoogle Scholar
  48. 48.
    Heras A, Rodriguez NM, Ramos VM, Agullo E (2001) Carbohydr Polym 44:1CrossRefGoogle Scholar
  49. 49.
    Zhang C, Ping QE, Zhang HJ, Shen J (2003) Eur Polym J 39:1629CrossRefGoogle Scholar
  50. 50.
    Focher B, Massoli A, Torri G, Gervasini A, Morazzoni F (1986) Macromol Chem Phys 187:2609CrossRefGoogle Scholar
  51. 51.
    Bodnar M, Hartmann JF, Borbely J (2006) Biomacromolecules 7:3030CrossRefGoogle Scholar
  52. 52.
    Goycoolea FM, Lollo G, Remunan-Lopez C, Quaglia F, Alonso MJ (2009) Biomacromolecules 10:1736CrossRefGoogle Scholar
  53. 53.
    Motwani SK, Chopra S, Talegaonkar S, Kohl K, Ahmad FJ, Khar RK (2008) Eur J Pharm Biopharm 68:513Google Scholar
  54. 54.
    Lee PW, Hsu SH, Wang JJ, Tsai JS, Lin KJ, Wey SP, Chen FR, Lai CH, Yen TC, Sung HW (2010) Biomaterials 31:1316CrossRefGoogle Scholar
  55. 55.
    Shi ZL, Neoh KG, Kang ET, Shuter B, Wang SC, Poh C, Wan W (2009) ACS Appl Mater Interfaces 1:328CrossRefGoogle Scholar
  56. 56.
    Zhu AP, Yuan LH, Jin WJ, Dai S, Wang QQ, Xue ZF, Qin AJ (2009) Acta Biomater 5:1489CrossRefGoogle Scholar
  57. 57.
    Kumar A, Jena PK, Behera S, Lockey RF, Mohapatra S, Mohapatra S (2010) Nanomed Nanotechnol Biol Med 6:64CrossRefGoogle Scholar
  58. 58.
    Lee HS, Kim EH, Shao HP, Kwak BK (2005) J Magn Magn Mater 293:102CrossRefGoogle Scholar
  59. 59.
    Sun Y, Chen ZL, Yang XX, Huang P, Zhou XP, Du XX (2009) Nanotechnology 20:135102Google Scholar
  60. 60.
    Li LL, Chen D, Zhang YQ, Deng ZT, Ren XL, Meng XW, Tang FQ, Ren J, Zhang L (2007) Nanotechnology 18:405102Google Scholar
  61. 61.
    Donadel K, Felisberto MDV, Favere VT, Rigoni M, Batistela NJ, Laranjeira MCM (2008) Mater Sci Eng C Biomim Supramol Syst 28:509CrossRefGoogle Scholar
  62. 62.
    Kim DH, Kim KN, Kim KM, Lee YK (2009) J Biomed Mater Res A 88A:1CrossRefGoogle Scholar
  63. 63.
    Zhang XL, Niu HY, Pan YY, Shi YL, Cai YQ (2010) Anal Chem 82:2363CrossRefGoogle Scholar
  64. 64.
    Du PC, Liu P, Mu B, Wang YJ (2010) J Polym Sci A Polym Chem 48:4981CrossRefGoogle Scholar
  65. 65.
    Zhu AP, Yuan LH, Liao TQ (2008) Int J Pharm 350:361CrossRefGoogle Scholar
  66. 66.
    Kim EH, Ahn Y, Lee HS (2007) J Alloys Compd 434:633CrossRefGoogle Scholar
  67. 67.
    Lei ZL, Pang XL, Li N, Lin L, Li YL (2009) J Mater Process Technol 209:3218CrossRefGoogle Scholar
  68. 68.
    Bhattarai SR, Badahur KCR, Aryal S, Khil MS, Kim HY (2007) Carbohydr Polym 69:467CrossRefGoogle Scholar
  69. 69.
    Ho KM, Li P (2008) Langmuir 24:1801CrossRefGoogle Scholar
  70. 70.
    Bhattarai SR, Kim SY, Jang KY, Lee KC, Yi HK, Lee DY, Kim HY, Hwang PH (2008) Nanomed Nanotechnol Biol Med 4:146CrossRefGoogle Scholar
  71. 71.
    Liang YY, Zhang LM (2007) Biomacromolecules 8:1480CrossRefGoogle Scholar
  72. 72.
    Zhu AP, Yuan LH, Dai S (2008) J Phys Chem C 112:5432CrossRefGoogle Scholar
  73. 73.
    Ge YQ, Zhang Y, Xia JG, Ma M, He SY, Nie F, Gu N (2009) Colloids Surf B Biointerfaces 73:294CrossRefGoogle Scholar
  74. 74.
    Yang LR, Guo C, Jia LW, Xie K, Shou QH, Liu HZ (2010) Ind Eng Chem Res 49:8518CrossRefGoogle Scholar
  75. 75.
    Yuan Q, Venkatasubramanian R, Hein S, Misra RDK (2008) Acta Biomater 4:1024CrossRefGoogle Scholar
  76. 76.
    Bahadur R, Lee SM, Yoo ES, Choi JH, Do Ghim H (2009) Mater Sci Eng C Biomim Supramol Syst 29:1668CrossRefGoogle Scholar
  77. 77.
    Cheong SJ, Lee CM, Kim SL, Jeong HJ, Kim EM, Park EH, Kim DW, Lim ST, Sohn MH (2009) Int J Pharm 372:169CrossRefGoogle Scholar
  78. 78.
    Lee CM, Jeong HJ, Kim SL, Kim EM, Kim DW, Lim ST, Jang KY, Jeong YY, Nah JW, Sohn MH (2009) Int J Pharm 371:163CrossRefGoogle Scholar
  79. 79.
    Tsai ZT, Wang JF, Kuo HY, Shen CR, Wang JJ, Yen TC (2010) J Magn Magn Mater 322:208CrossRefGoogle Scholar
  80. 80.
    Li BQ, Jia DC, Zhou Y, Hu QL, Cai W (2006) J Magn Magn Mater 306:223CrossRefGoogle Scholar
  81. 81.
    Wang YL, Li BQ, Zhou Y, Jia DC (2008) Polym Adv Technol 19:1256CrossRefGoogle Scholar
  82. 82.
    Shen C-R, Juang J-H, Tsai Z-T, Wu S-T, Tsai F-Y, Wang J-J, Liu C-L, Yen T-C (2011) Carbohydr Polym 84:781Google Scholar
  83. 83.
    Lee MJ-E, Veiseh O, Bhattarai N, Sun C, Hansen SJ, Ditzler S, Knoblaugh S, Lee D, Ellenbogen R, Zhang MQ, Olson JM (2010) PLoS One 5:e9536Google Scholar
  84. 84.
    Gunn J, Park SI, Veiseh O, Press OW, Zhang M (2011) Mol Biosyst 7:742Google Scholar
  85. 85.
    Hou YC, Tsai SY, Lai PY, Chen YS, Chao PDL (2008) Food Chem Toxicol 46:2764CrossRefGoogle Scholar
  86. 86.
    Mizukoshi Y, Shuto T, Masahashi N, Tanabe S (2009) Ultrason Sonochem 16:525CrossRefGoogle Scholar
  87. 87.
    Fernandez-Megia E, Novoa-Carballal R, Quinoa E, Riguera R (2007) Biomacromolecules 8:833CrossRefGoogle Scholar
  88. 88.
    Byrne JD, Betancourt T, Brannon-Peppas L (2008) Adv Drug Deliv Rev 60:1615CrossRefGoogle Scholar
  89. 89.
    Sunderland CJ, Steiert M, Talmadge JE, Derfus AM, Barry SE (2006) Drug Dev Res 67:70CrossRefGoogle Scholar
  90. 90.
    Gindy M, Prod’homme RK (2009) Expert Opin Drug Deliv 6:865CrossRefGoogle Scholar
  91. 91.
    Boesch C (1999) Mol Aspects Med 20:185CrossRefGoogle Scholar
  92. 92.
    Reddy AM, Kwak BK, Shim HJ, Ahn C, Lee HS, Suh YJ, Park ES (2010) J Korean Med Sci 25:211Google Scholar
  93. 93.
    Cho K, Wang X, Nie S, Chen Z, Shin DM (2008) Clin Cancer Res 14:1310CrossRefGoogle Scholar
  94. 94.
    Rao J, Dragulescu-Andrasi A, Yao H (2007) Curr Opin Biotechnol 18:17CrossRefGoogle Scholar
  95. 95.
    Jiang S, Gnanasammandhan MK, Zhang Y (2010) J Roy Soc Interface 7:3Google Scholar
  96. 96.
    Cheng Z, Wu Y, Xiong Z, Gambhir SS, Chen X (2005) Bioconjug Chem 16:1433CrossRefGoogle Scholar
  97. 97.
    McBain S, Yiu H, Dobson J (2008) Int J Nanomed 3:169Google Scholar
  98. 98.
    Shivang RD, Xiaohu G (2009) Wiley Interdis Rev Nanomed Nanobiotechnol 1:583CrossRefGoogle Scholar
  99. 99.
    Park TG, Jeong JH, Kim SW (2006) Adv Drug Deliv Rev 58:467CrossRefGoogle Scholar
  100. 100.
    Jayakumar R, Prabaharan M, Nair SV, Tamura H (2010) Biotechnol Adv 28:142CrossRefGoogle Scholar
  101. 101.
    Tan ML, Choong PFM, Dass CR (2009) J Pharm Pharmacol 61:3CrossRefGoogle Scholar
  102. 102.
    Wang DS, Li JG, Li HP, Tang FQ (2009) Tran Nonferrous Metals Soc China 19:1232Google Scholar
  103. 103.
    Mansouri S, Lavigne P, Corsi K, Benderdour M, Beaumont E, Fernandes JC (2004) Eur J Pharm Biopharm 57:1CrossRefGoogle Scholar
  104. 104.
    Lee KY (2007) Macromol Res 15:195CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Hamed Arami
    • 1
  • Zachary Stephen
    • 1
  • Omid Veiseh
    • 1
  • Miqin Zhang
    • 1
  1. 1.Department of Materials Science and EngineeringUniversity of WashingtonSeattleUSA

Personalised recommendations