Abstract
Shape-memory polymers (SMPs) are a class of mechanically functional “smart” materials that have generated substantial interest for biomedical applications. SMPs offer the ability to promote minimally invasive surgery, provide structural support, exert stabilizing forces, elute therapeutic agents, and biodegrade. This review focuses on several areas of biomedicine including vascular, orthopedic, and neuronal applications with respect to the progress and potential for SMPs to improve the standard of treatment in these areas. Fundamental studies on proposed biomedical SMP systems are discussed with regards to biodegradability, tailorability, sterilization, and biocompatibility. Lastly, a proposed research and development pathway for SMP-based biomedical devices is proposed based on trends in the recent literature.
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Abbreviations
- ACL:
-
Anterior cruciate ligament
- CHEM:
-
Cold hibernated elastic memory
- DES:
-
Drug-eluting stent
- \({E}_{\mathrm{r}}^{{\prime}}\) :
-
Rubbery modulus
- EtO:
-
Ethylene oxide
- FDA:
-
Food and Drug Administration
- LTP:
-
Low temperature plasma
- PCL:
-
Poly(ε-caprolactone)
- PLA:
-
Polylactic acid
- PLLA:
-
Poly(L-lactide)
- SMP:
-
Shape-memory polymer
- Tdeform :
-
Temperature of deformation
- Tg :
-
Glass transition temperature
- Tonset :
-
Onset of the glass transition
- Ttrans :
-
Transition temperature
- US:
-
United States
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Acknowledgments
The authors would like to thank Jack “Mac” Griffis MS for his expert consultation in vascular devices. The authors would also like to thank Kurt Jacobus Ph.D., Carl Frick Ph.D., Alicia M. Ortega, Sean Dixon, Jordan Rakes, and Jhordan Gil for their support and careful review of this work.
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Yakacki, C.M., Gall, K. (2009). Shape-Memory Polymers for Biomedical Applications. In: Lendlein, A. (eds) Shape-Memory Polymers. Advances in Polymer Science, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2009_23
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