Parallel Optimization and High-Throughput Preparation of Well-Defined Copolymer Libraries Using Controlled/“Living” Polymerization Methods

  • C. Remzi Becer
  • Ulrich S. Schubert
Part of the Advances in Polymer Science book series (POLYMER, volume 225)


This chapter highlights the application of controlled/“living” polymerization (CLP) techniques in automated parallel synthesizers for both optimizing reaction parameters as well as preparing copolymer libraries. Special attention is given to the use of CLP techniques for constructing well-defined copolymer libraries. Furthermore, alternative strategies for the preparation of block copolymer libraries are discussed.


Automated parallel synthesis Block copolymers High-throughput experimentation Polymer libraries Random copolymers 



Acrylic acid


Acetyl bromide


Acetyl chloride


Acetyl iodide


Atomic force microscopy




N-Acryoyl morpholine


Atom transfer radical polymerization


(1-Bromo ethyl) benzene


4, 4 -Dialkyl substituted bipyridine


2-Bromo-2-methylpropanoyl bromide


2-Cyano-2-butyl dithio benzoate


Controlled/“living” polymerization


Cationic ring opening polymerization


Controlled radical polymerization


Chain transfer agent


N,N-Dimethyl acrylamide


N,N-Dimethyl acetamide


N,N-Dimethyl aminoethyl acrylamide


N,N-Dimethyl formamide


Degree of polymerization


Differential scanning calorimetry


1-Ethoxy ethyl acrylate






Gas chromatography


2-Hydoxypropyl acrylate




Lower critical solution temperature


Methyl acrylate


Methacrylic acid


Macromolecular design via the interchange of xanthates


Methyl bromo propionate


Methyl methacrylate


2-Methoxyethyl 2-methylacrylate


2-(2-Methoxyethoxy)ethyl 2-methylacrylate




Number average molar mass


n-Butyl acrylate


N-Isopropyl acrylamide


Nitroxide mediated polymerization


Nuclear magnetic resonance




Oligo(ethyleneglycol) methyl ether methacrylate


Oligo(ethylene glycol) ethyl ether methacrylate


Poly(acrylic acid)


Polydispersity index


Poly(1-ethoxyethyl acrylate)




Poly(ethylene oxide)




Poly(N,N-dimethyl aminoethyl methacrylate)


Poly(methyl acrylate)


Poly(methyl methacrylate)


Poly(n-butyl acrylate)




Poly(tert-butyl acrylate)


Reversible addition-fragmentation chain transfer


Size exclusion chromatography




Solid phase extraction






tert-Butyl acrylate


2,2,6,6-Tetramethyl-1-piperidinyloxy stable radical


Glass transition temperature


Thermal gravimetric analysis


p-Toluene sulfonyl chloride



Financial support from the Dutch Polymer Institute (DPI project #502) is gratefully acknowledged.


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© Springer 2010

Authors and Affiliations

  1. 1.Laboratory of Macromolecular Chemistry and NanoscienceEindhoven University of TechnologyEindhovenThe Netherlands
  2. 2.Laboratory of Organic and Macromolecular ChemistryFriedrich-Schiller-University JenaJenaGermany
  3. 3.Dutch Polymer InstituteEindhovenThe Netherlands

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