Polymer Libraries pp 17-62

Part of the Advances in Polymer Science book series (POLYMER, volume 225)

Parallel Optimization and High-Throughput Preparation of Well-Defined Copolymer Libraries Using Controlled/“Living” Polymerization Methods

Chapter

Abstract

This chapter highlights the application of controlled/“living” polymerization (CLP) techniques in automated parallel synthesizers for both optimizing reaction parameters as well as preparing copolymer libraries. Special attention is given to the use of CLP techniques for constructing well-defined copolymer libraries. Furthermore, alternative strategies for the preparation of block copolymer libraries are discussed.

Keywords

Automated parallel synthesis Block copolymers High-throughput experimentation Polymer libraries Random copolymers 

Abbreviations

AA

Acrylic acid

AcBr

Acetyl bromide

AcCl

Acetyl chloride

AcI

Acetyl iodide

AFM

Atomic force microscopy

AIBN

α,α-Azobisisobutyronitrile

Amor

N-Acryoyl morpholine

ATRP

Atom transfer radical polymerization

BEB

(1-Bromo ethyl) benzene

bpy

4, 4-Dialkyl substituted bipyridine

BrEBiB

2-Bromo-2-methylpropanoyl bromide

CBDB

2-Cyano-2-butyl dithio benzoate

CLP

Controlled/“living” polymerization

CROP

Cationic ring opening polymerization

CRP

Controlled radical polymerization

CTA

Chain transfer agent

DMA

N,N-Dimethyl acrylamide

DMAc

N,N-Dimethyl acetamide

DMAEMA

N,N-Dimethyl aminoethyl acrylamide

DMF

N,N-Dimethyl formamide

DP

Degree of polymerization

DSC

Differential scanning calorimetry

EEA

1-Ethoxy ethyl acrylate

EBIB

Ethyl-2-bromo-iso-butyrate

EtOx

2-Ethyl-2-oxazoline

GC

Gas chromatography

HPA

2-Hydoxypropyl acrylate

iPrOx

2-iso-Propyl-2-oxazoline

LCST

Lower critical solution temperature

MA

Methyl acrylate

MAA

Methacrylic acid

MADIX

Macromolecular design via the interchange of xanthates

MBP

Methyl bromo propionate

MMA

Methyl methacrylate

MeOMA

2-Methoxyethyl 2-methylacrylate

MeO2MA

2-(2-Methoxyethoxy)ethyl 2-methylacrylate

MeOx

2-Methyl-2-oxazoline

Mn

Number average molar mass

nBA

n-Butyl acrylate

NIPAM

N-Isopropyl acrylamide

NMP

Nitroxide mediated polymerization

NMR

Nuclear magnetic resonance

NonOx

2-Nonyl-2-oxazoline

OEGMA

Oligo(ethyleneglycol) methyl ether methacrylate

OEGEMA

Oligo(ethylene glycol) ethyl ether methacrylate

PAA

Poly(acrylic acid)

PDI

Polydispersity index

PEEA

Poly(1-ethoxyethyl acrylate)

PEG

Poly(ethyleneglycol)

PEO

Poly(ethylene oxide)

PheOx

2-Phenyl-2-oxazoline

PDMAEMA

Poly(N,N-dimethyl aminoethyl methacrylate)

PMA

Poly(methyl acrylate)

PMMA

Poly(methyl methacrylate)

PnBA

Poly(n-butyl acrylate)

PSt

Poly(styrene)

PtBA

Poly(tert-butyl acrylate)

RAFT

Reversible addition-fragmentation chain transfer

SEC

Size exclusion chromatography

s-BuLi

sec-Butyllithium

SPE

Solid phase extraction

SoyOx

2-“Soyalkyl”-2-oxazoline

St

Styrene

tBA

tert-Butyl acrylate

TEMPO

2,2,6,6-Tetramethyl-1-piperidinyloxy stable radical

Tg

Glass transition temperature

TGA

Thermal gravimetric analysis

TsCl

p-Toluene sulfonyl chloride

Copyright information

© Springer 2010

Authors and Affiliations

  1. 1.Laboratory of Macromolecular Chemistry and NanoscienceEindhoven University of TechnologyEindhovenThe Netherlands
  2. 2.Laboratory of Organic and Macromolecular ChemistryFriedrich-Schiller-University JenaJenaGermany
  3. 3.Dutch Polymer InstituteEindhovenThe Netherlands

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