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Solid-State Structure, Organizationand Properties of Peptide—Synthetic Hybrid Block Copolymers

  • Harm-Anton KlokEmail author
  • Sébastien LecommandouxEmail author
Chapter
Part of the Advances in Polymer Science book series (POLYMER, volume 202)

Abstract

Peptide–synthetic hybrid block copolymers are most easily prepared via ring-opening polymerization of α-amino acid N-carboxyanhydrides using appropriately end-functionalized synthetic polymers as the macroinitiator. This class of peptide–synthetic hybrid block copolymers has been the subject of longstanding scientific interest. First reports on the structure and properties of these hybrid block copolymers date from the 1970s. The advent of more refined analytical tools has spurred the interest in these materials and has led to an increased understanding of their structure and properties. This article presents an overview of the solid-state structure, organization and properties of the major classes of peptide–synthetic hybrid block copolymers, classified according to the chemical composition of the synthetic polymer block. For each of these classes of block copolymers, results from earlier morphological studies will be discussed and compared and complemented with more recent results. Properties and possible applications of peptide–synthetic hybrid block copolymers will also be pointed out.

Block copolymers Polypeptides Self-assembly 

Abbreviations

AFM

atomic force microscopy

BF

bovine fibrinogen

BγG

bovine γ globulin

BPF

bovine plasma fibrinogen

BSA

bovine serum albumine

CD

circular dichroism

DMF

N,N-dimethylformamide

DSC

differential scanning calorimetry

FDA

U.S. Food and Drug Administration

FTIR

Fourier transform infrared

IR

infrared

PB

polybutadiene

PBA

poly(butadiene-co-acrylonitrile)

PBLA

poly(β-benzyl-l-aspartate)

PBDLG

poly(γ-benzyl-d,l-glutamate)

PBLG

poly(γ-benzyl-l-glutamate)

PCL

poly(ε-caprolactone)

PDMS

polydimethylsiloxane

PEG

poly(ethylene glycol)

PECF

pseudoextracellular fluid

PELG

poly(γ-ethyl-l-glutamate)

PEUU

polyetherurethaneurea

PHF

poly(9,9-dihexylfluorene-2,7-diyl)

PHPG

poly(N5-hydroxypropyl-l-glutamine)

PI

polyisoprene

PLA

poly(l-alanine)

PLL

poly(l-lysine)

PLLA

poly(l-lactic acid)

PMLG

poly(γ-methyl-l-glutamate)

PMDLG

poly(γ-methyl-d,l-glutamate)

PPG

poly(propylene glycol)

PS

polystyrene

PTHF

poly(tetrahydrofuran)

PZLL

poly(ε-benzyloxycarbonyl-l-lysine)

SAXS

small angle X-ray scattering

TFA

trifluoroacetic acid

Tg

glass transition temperature

TEM

transmission electron microscopy

THF

tetrahydrofuran

WAXS

wide angle X-ray scattering

XPS

X-ray photoelectron spectroscopy

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Authors and Affiliations

  1. 1.Ecole Polytechnique Fédérale de Lausanne (EPFL)Institut des Matériaux,Laboratoire des PolymèresLausanneSwitzerland
  2. 2.Laboratoire de Chimie des Polymères Organiques, LCPO (UMR5629) – CNRS – ENSCPBUniversité Bordeaux 1Pessac cedexFrance

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