Solution Properties of Polypeptide-based Copolymers

  • Helmut SchlaadEmail author
Part of the Advances in Polymer Science book series (POLYMER, volume 202)


The aggregation behaviour of biomimetic polypeptide hybrid copolymers and copolypeptides is here reviewed with a particular eye on the occurrence of secondary structure effects. Structure elements like α-helix or β-sheet can induce a deviation from the “classical” phase behaviour and promote the formation of vesicles or hierarchical superstructures with ordering in the length-scale of microns. Polypeptide copolymers are therefore considered as models to study self-assembly processes in biological systems. In addition, they offer a great potential for a production of novel advanced materials and colloids.

Block copolymer Peptide Secondary structure Self-assembly Vesicle Hierarchical structure 





Analytical ultracentrifugation




Circular dichroism


Differential interference contrast


Dynamic light scattering


Fourier-transform infrared


Laser scanning confocal microscopy


Lower critical solution temperature




Nuclear magnetic resonance


Polarisation optical microscopy


Small-angle neutron scattering


Small-angle X-ray scattering


Scanning force microscopy


Static light scattering


Scanning electron microscopy


Transmission electron microscopy








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The author would like to thank his former coworkers Hildegard Kukula, Magdalena Losik, and Rémi Soula for working in the field of polypeptide hybrid polymers and also Markus Antonietti and Erich C. Financial support was given by the Max Planck Society.


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Authors and Affiliations

  1. 1.Max Planck Institute of Colloids and InterfacesColloid DepartmentPotsdam-GolmGermany

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