Abstract
This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize α-amino acid-N-carboxyanhydrides (NCAs) are described, and limitations in the utility of these systems for the preparation of polypeptides are discussed. Recently developed initiators and methods are also discussed that allow polypeptide synthesis with good control over chain length, chain length distribution, and chain-end functionality. The latter feature is particularly useful for the preparation of polypeptide hybrid copolymers. The methods and strategies for the preparation of such hybrid copolymers are described, as well as analysis of the synthetic scope of the different methods. Finally, issues relating to obtaining these highly functional copolymers in pure form are detailed.
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Abbreviations
- NCA:
-
α-amino acid N-carboxyanhydride
- AM:
-
activated monomer
- GPC:
-
gel permeation chromatography
- NACE:
-
non-aqueous capillary electrophoresis
- PBLG:
-
poly(γ-benzyl-l-glutamate)
- PMLG:
-
poly(γ-methyl-l-glutamate)
- PMDG:
-
poly(γ-methyl-d-glutamate)
- PML/DG:
-
poly(γ-methyl-rac-glutamate)
- PZLL:
-
poly(ε-carbobenzyloxy-l-lysine)
- PBLA:
-
poly(β-benzyl-l-aspartate)
- PMA:
-
polymethylacrylate
- PEG:
-
polyethylene glycol
- depe:
-
bis(diethylphosphino)ethane
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Deming, T.J. Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization. In: Klok, HA., Schlaad, H. (eds) Peptide Hybrid Polymers. Advances in Polymer Science, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_080
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DOI: https://doi.org/10.1007/12_080
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