Polymers for Regenerative Medicine pp 191-221

Part of the Advances in Polymer Science book series (POLYMER, volume 203) | Cite as

Polymeric Systems for Bioinspired Delivery of Angiogenic Molecules

Chapter

Abstract

Growth factors are increasingly utilized to promote regeneration of lost or compromised tissues and organs. However, current strategies applying growth factors by bolus injections typically fail to restore tissue functions. Delivery from polymeric systems may overcome this limitation by supplying growth factors in a well-controlled, localized, and sustained manner to the defect site. Traditional polymeric delivery vehicles have been developed based on physicochemical design variables; however, it has now become clear that the appropriate mimicry of certain biologic signaling events may be necessary to achieve full function from the delivered growth factors. Because of its central importance in the development and regeneration of various tissues (e.g., blood vessels, bone, and nerves) bioinspired VEGF supply may be particularly useful to successfully restore tissue functions. Following a brief overview of VEGF's biology, design attributes for polymeric systems for VEGF delivery will be discussed, and subsequently illustrated in the context of three specific applications: therapeutic angiogenesis, bone regeneration, and nerve regeneration.

Angiogenesis Drug delivery Growth factor Polymer VEGF 

Abbreviations

Ang-1

angiopoietin-1

Ang-2

angiopoietin-2

bFGF

basic fibroblast growth factor

BMP-2

bone morphogenetic protein-2

3-D

three-dimensional

ECM

extracellular matrix

G

alpha-L-guluronic acid

LCST

lower critical solution temperature

M

beta-D-mannuronic acid

MW

molecular weight

MMP

matrix metalloproteinase

NGF

nerve growth factor

NRP

neuropilin

PAA

poly(acrylic acid)

PDGF

platelet derived growth factor

PEG

poly(ethylene glycol)

PEI

poly(ethylenimine)

PGA

poly(glycolic acid)

PLA

poly(lactic acid)

PLGA

poly(lactic-co-glycolic acid)

PNIPAAm

poly(N-isopropylacrylamide)

PPE-EA

polyaminoethyl propylene phosphate

RGD

arginine-glycine-aspartic acid

GRGD

glycine-arginine-aspartic acid

Tg

glass transition temperature

TGF-beta

transforming growth factor-beta

VEGF

vascular endothelial growth factor

VEGF-R

vascular endothelial growth factor receptor

VPF

vascular permeability factor

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Authors and Affiliations

  1. 1.Division of Engineering and Applied SciencesHarvard UniversityCambridgeUSA

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