Hypervalent Iodine-Induced Oxidative Couplings (New Metal-Free Coupling Advances and Their Applications in Natural Product Syntheses)

  • Toshifumi Dohi
  • Yasuyuki KitaEmail author
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 373)


Recently, hypervalent iodine reagents have been extensively used in organic synthesis. A variety of reactions available for natural product syntheses have been developed using phenyliodine(III) diacetate (PIDA), phenyliodine(III) bis(trifluoroacetate) (PIFA), and other iodine(III) and (V) reagents. These reactions are expected to have applications in pharmaceutical and agrochemical processes because of their safety, mild reaction conditions, and high yields of pure products. Under such considerations, this chapter focuses on the oxidative coupling reactions of hypervalent iodine reagents found in total syntheses of biologically active natural products and their related compounds.


Hypervalent iodine reagents Natural products Oxidative coupling Total synthesis 


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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.College of Pharmaceutical ScienceRitsumeikan UniversityKusatsuJapan
  2. 2.Research Organization of Science and TechnologyRitsumeikan UniversityKusatsuJapan

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