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Gas-Phase IR Spectroscopy and Structure of Biological Molecules pp 225–270Cite as

Isolated Neutral Peptides

Part of the Topics in Current Chemistry book series (TOPCURRCHEM,volume 364)

Abstract

This chapter examines the structural characterisation of isolated neutral amino-acids and peptides. After a presentation of the experimental and theoretical state-of-the-art in the field, a review of the major structures and shaping interactions is presented. Special focus is made on conformationally-resolved studies which enable one to go beyond simple structural characterisation; probing flexibility and excited-state photophysics are given as examples of promising future directions.

Keywords

  • Amide
  • Amino-acid
  • Backbone-side chain interactions
  • Conformation-selective IR spectroscopy
  • Gas phase laser spectroscopy
  • Hydrates
  • Secondary structures
  • Supersonic expansion

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  • DOI: 10.1007/128_2014_580
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Abbreviations

Ac:

Acetyl

Aib:

Aminoisobutyric acid

BB:

Backbone

Bn:

Benzyl

CI:

Conical intersection

CT:

Charge transfer

DFT:

Density functional theory

FC:

Franck–Condon

FEL:

Free electron laser

FTIR:

Fourier transform infrared

IR:

Infrared

LE:

Locally excited

Me:

Methyl

NCI:

Non-covalent interactions

OPO:

Optical parametric oscillator

PES:

Potential energy surface

SC:

Side-chain

SEP:

Stimulated emission pumping

UV:

Ultraviolet

VUV:

Vacuum ultraviolet

Z:

Benzyloxycarbonyl

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Authors and Affiliations

  1. CNRS, INC and INP, Lab. Francis Perrin, 91191, Gif-sur-Yvette, France

    Eric Gloaguen & Michel Mons

  2. CEA, IRAMIS, Laboratoire Interactions, Dynamique et Lasers, 91191, Gif-sur-Yvette, France

    Eric Gloaguen & Michel Mons

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  1. Eric Gloaguen
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  1. Molecular and Biophysics, FELIX Laboratory, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands

    Anouk M. Rijs

  2. Molecular Structure and Dynamics, FELIX Laboratory, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands

    Jos Oomens

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Gloaguen, E., Mons, M. (2014). Isolated Neutral Peptides. In: Rijs, A., Oomens, J. (eds) Gas-Phase IR Spectroscopy and Structure of Biological Molecules. Topics in Current Chemistry, vol 364. Springer, Cham. https://doi.org/10.1007/128_2014_580

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