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Protein Dynamics and the Enzymatic Reaction Coordinate

  • Steven D. Schwartz
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 337)

Abstract

This chapter discusses progress over the past 15 years in understanding the role of protein dynamics in enzymatically catalyzed chemical reactions. Research has shown that protein motion on all timescales from femtoseconds to milliseconds can contribute to function, and in particular in some enzymes there are sub-picosecond motions, on the same timescale as barrier passage, the couple directly to chemical transformation, and are thus part of the reaction coordinate. Approaches such as transition path sampling and committor analysis have greatly enhanced our understanding of these processes.

Keywords

Reaction Coordinate Protein Motion Rate Theory Protein Dynamic Transition State Theory 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of ArizonaTucsonUSA

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