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Transgenic Mouse Models and Prion Strains

  • Glenn C. TellingEmail author
Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 305)

Abstract

Here we review the known strain profiles of various prion diseases of animals and humans, and how transgenic mouse models are being used to elucidate basic molecular mechanisms of prion propagation and strain variation and for assessing the zoonotic potential of various animal prion strains.

Keywords

Quasi-species Species barriers Strains Transgenic models 

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Copyright information

© Springer-Verlag Berlin-Heidelberg 2011

Authors and Affiliations

  1. 1.Sanders Brown Center on AgingUniversity of Kentucky Medical CenterLexingtonUSA
  2. 2.Department of Microbiology, Immunology and Molecular GeneticsUniversity of Kentucky Medical CenterLexingtonUSA
  3. 3.Department of NeurologyUniversity of Kentucky Medical CenterLexingtonUSA

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