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Microfluidics pp 323-338 | Cite as

Microfluidic Platform for the Study of Caenorhabditis elegans

  • Weiwei Shi
  • Hui Wen
  • Bingcheng Lin
  • Jianhua QinEmail author
Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 304)

Abstract

Caenorhabditis elegans is a well-established model organism for the study of various biological areas. However, the procedures generally used for this worm are limited by the low throughput, low automation, and imprecise delivery of external stimuli. Microfluidics technology is emerging as an attractive and enabling platform to overcome these problems. In this review, we summarize the current microfluidic approaches for the investigation of behavior and neurobiology in C. elegans, and discuss the trends of future development.

Keywords

Caenorhabditis elegans Microfluidics Neurobiology Neuron degeneration Neuron regeneration 

Abbreviations

6-OHDA

Neurotoxin 6-hydroxydopamine

C. elegans

Caenorhabditis elegans

MPP+

1-Methyl-4-phenylpyridinium ion

MPTP

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

PD

Parkinson’s disease

PDMS

Polydimethylsiloxane

RNAi

RNA interference

Notes

Acknowledgements

This paper was supported by the National Nature Science Foundation of China (No. 20635030 and 90713014), Key Project of Chinese National Programs for Fundamental Research and Development (973 program, No. 2007CB714505 and 2007CB714507), Knowledge Innovation Program of the Chinese Academy of Sciences (KJCX2-YW-H18), and Instrument Research and Development Program of the Chinese Academy of Sciences (YZ200908).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Weiwei Shi
    • 1
  • Hui Wen
    • 1
  • Bingcheng Lin
    • 1
  • Jianhua Qin
    • 1
    Email author
  1. 1.Dalian Institute of Chemistry and PhysicsChinese Academy of SciencesDalianChina

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