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Microfluidics pp 171-201 | Cite as

Optical Detection Systems on Microfluidic Chips

  • Hongwei GaiEmail author
  • Yongjun LiEmail author
  • Edward S. Yeung
Chapter
Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 304)

Abstract

Optical detection continues to dominate detection methods in microfluidics due to its noninvasive nature, easy coupling, rapid response, and high sensitivity. In this review, we summarize two aspects of recent developments in optical detection methods on microfluidic chips. The first aspect is free-space (off-chip) detection on the microchip, in which the conventional absorption, fluorescence, chemiluminescence, surface plasmon resonance, and surface enhanced Raman spectroscopies are involved. The second aspect is the optofluidic (inside-chip) detection. Various miniaturized optical components integrated on the microfluidic chip, such as waveguide, microlens, laser, and detectors are outlined.

Keywords

Lab-on-a-chip Optofluidic Point of care 

Abbreviations

μ-TAS

Micro total analysis system

ARROWs

Antiresonant reflecting optical waveguides

CCD

Charge-coupled device

CE

Capillary electrophoresis

CL

Chemiluminescence

CMOS

Complementary metal-oxide-semiconductor

DFB

Distributed feedback

HRP

Horseradish peroxidase

L2 waveguide

Liquid-core/liquid-cladding waveguide

LCW

Liquid-core waveguide

LED

Light-emitting diode

L-GRIN

Liquid gradient refractive index

LIF

Laser-induced fluorescence

(L)SPR

(Localized) surface plasmon resonance

OFM

Optofluidic microscopy

OPD

Organic photodiode

PC

Photonic crystal

PDMS

Poly(dimethylsiloxane)

PMMA

Poly(methyl methacrylate)

PMTs

Photomultiplier tubes

QD

Quantum dot

SERS

Surface enhanced Raman spectroscopy

UV/Vis

Ultraviolet–visible

Notes

Acknowledgments

The authors would like to thank Xingbo Shi, Xinliang Liu, Lichun Sun, and Haixia Ding for helpful discussions. HWG gratefully acknowledges the support of National Natural Science Foundation of China (20705007, 21075033, 20703016).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.School of Chemistry and Chemical EngineeringXuzhou Normal UniversityXuzhouChina
  2. 2.State Key Laboratory of Chemo/Biosensing and ChemometricsHunan UniversityChangshaChina
  3. 3.School of BiologyHunan UniversityChangshaChina
  4. 4.School of Chemistry and Chemical EngineeringHunan UniversityChangshaChina

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